Advancements in nanomedicine: Precision delivery strategies for male pelvic malignancies - Spotlight on prostate and colorectal cancer [0.03%]
纳米医学的进步：男性盆腔恶性肿瘤的精准递送策略——聚焦前列腺癌和结直肠癌
Guodong Yang,Yu Cao,Xinyi Yang et al.
Guodong Yang et al.
Background: Pelvic malignancies consistently pose significant global health challenges, adversely affecting the well-being of the male population. It is anticipated that clinicians will continue to confront these cancers ...
Rabeah Al-Temaimi,Nashmeiah Alshammari,Raed Alroughani
Rabeah Al-Temaimi
Multiple sclerosis (MS) is a chronic demyelinating autoimmune neurodegenerative disorder for which no specific blood biomarker is available. MicroRNAs (miRNAs) have been investigated for their diagnostic potential in MS. However, MS-associa...
Predictive molecular pathology after prolonged fixation: A study on tissue from anatomical body donors [0.03%]
长期取材后的预测分子病理学：来自解剖尸体捐赠者的组织研究
Anja Böckers,Leon Schurr,Michael Schön et al.
Anja Böckers et al.
Histopathological assessment of tissue samples after prolonged formalin fixation has been described previously, but currently there is only limited knowledge regarding the feasibility of molecular pathology on such tissue. In this pilot stu...
Sodium acetate prevents testicular damage in Wistar rats subjected to testicular ischaemia/reperfusion injury [0.03%]
醋酸钠对Wistar大鼠睾丸缺血再灌注损伤的保护作用
Elizabeth Enohnyket Besong,Roland Eghoghosoa Akhigbe
Elizabeth Enohnyket Besong
Aims: The aim of this study was to investigate the potential antioxidant, anti-inflammatory, and sperm function-preserving properties of sodium acetate (ACE), a histone deacetylase (HDAC) inhibitor, in a rat model of test...
Fate control engagement augments NK cell responses in LV/hu-IL-12 transduced sarcoma [0.03%]
命运控制参与增强LV/人类IL-12转导的肉瘤中的NK细胞反应
Mary Jo Rademacher,Mary L Faber,Kathleen M Bone et al.
Mary Jo Rademacher et al.
Introduction: NK cells are an untapped resource for cancer therapy. Sarcomas transduced with lentiviruses to express human IL-12 are only cleared in mice bearing mature human NK cells. However, systemic inflammation limit...
Urinary soluble CD163 is a putative non-invasive biomarker for primary sclerosing cholangitis [0.03%]
可溶性CD163尿检是原发性硬化性胆管炎潜在的无创性生物标志物
Tanja Elger,Tanja Fererberger,Muriel Huss et al.
Tanja Elger et al.
Soluble CD163 (sCD163) is a selective marker of macrophages whose circulating levels have been found to be induced in patients with active inflammatory bowel disease (IBD). Urinary proteins are emerging as non-invasive diagnostic biomarkers...
Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk [0.03%]
循环中的磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）扰动与心血管疾病患者中具有胰岛素抵抗风险的的心脏重塑及NLRP3炎性小体相关
Elena Vianello,Federico Ambrogi,Marta Kalousová et al.
Elena Vianello et al.
Lipidome perturbation occurring during meta-inflammation is associated to left ventricle (LV) remodeling though the activation of the NLRP3 inflammasome, a key regulator of chronic inflammation in obesity-related disorders. Little is known ...
Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model [0.03%]
利用富含基质的肿瘤模型分析GLS1抑制剂CB-839在结直肠癌中抗肿瘤作用及机制分析
Ryo Miyamoto,Hidehiko Takigawa,Ryo Yuge et al.
Ryo Miyamoto et al.
Background: Glutaminase 1 (GLS1), a key enzyme in glutamine metabolism in cancer cells, acts as a tumor promoter and could be a potential therapeutic target. CB-839, a GLS1-specific inhibitor, was developed recently. Here...
Effects of toll-like receptor agonists and SARS-CoV-2 antigens on interferon (IFN) expression by peripheral blood CD3+ T cells from COVID-19 patients [0.03%]
SARS-CoV-2感染患者外周血CD3+T细胞中 toll样受体激动剂和SARS-CoV-2抗原对I型干扰素表达的影响
Samaneh Abdolmohammadi-Vahid,Behzad Baradaran,Armin Sadeghi et al.
Samaneh Abdolmohammadi-Vahid et al.
Background: Signaling by toll-like receptors (TLRs) initiates important immune responses against viral infection. The role of TLRs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well eluc...
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development [0.03%]
降解蛋白酶功能下降在压疮发病早期会增加氧化应激反应
Eri Murata,Takuma Yoshida,Utano Tomaru et al.
Eri Murata et al.
The aging process in the elderly results in heightened skin fragility associated with various disorders, including pressure ulcers (PUs). Despite the high incidence of PUs in the elderly population, there is a limited body of research speci...