Ahtesham Hussain,Sanjay Srivastava,Igor N Zelko
Ahtesham Hussain
Benzene is among the most produced chemicals in the United States, and epidemiological evidence links benzene exposure to impaired pulmonary function; yet, the influence of pre-existing metabolic disease on susceptibility remains poorly def...
Integrating experimental data and mechanistic modeling to assess potential lead exposure from tampon use [0.03%]
结合实验数据和机理模型评估卫生护垫使用潜在的铅暴露风险
Corie A Ellison,Patrick R Doyle,Christina A Haven et al.
Corie A Ellison et al.
Trace levels of lead (Pb) have been reported in tampons, prompting concerns about potential exposure during menstrual product use. However, the presence of a chemical in a product does not necessarily translate to biologically relevant expo...
Contemporary Review: Temporal Dynamics of Neuroinflammation in Response to Environmental Exposure [0.03%]
环境暴露下神经炎症的时空动态响应当代评论
Brenna Baird,Shahani Noor,Shuguang Leng et al.
Brenna Baird et al.
Neuroinflammation is the brain's immune response to injury or disease and can negatively impact neurological functions, ranging from mood, cognition, learning and memory, as well as promote neurodegenerative disease and even psychiatric con...
RENAsym, a Quantitative Systems Toxicology Platform Model, Designed to Predict Drug-Induced Kidney Injury Indicates Polymyxin B and Valproate Overdose Toxicity Potential While Simultaneously Demonstrating Acetaminophen and Valproate Safety at Therapeutic Levels [0.03%]
一种定量系统毒理学平台模型RENAsym，可预测药物引起的肾脏损伤，表明多黏菌素B和丙戊酸过量具有毒性潜力，而同时证明治疗剂量的对乙酰氨基酚和丙戊酸是安全的
Celeste Vallejo,Pallavi Bhargava,Nader Hamzavi et al.
Celeste Vallejo et al.
RENAsym is a quantitative systems toxicology (QST) modeling platform designed to predict drug-induced kidney toxicity. The model includes the proximal tubule cell (PTC) life cycle, regeneration of PTCs, sodium reabsorption, nephron death, a...
RNAseq analysis demonstrates polarization state-dependent responses to ambient particulate matter in a particle composition-specific manner [0.03%]
基于颗粒物组成的RNA测序分析展示环境颗粒物质依赖极化状态的反应性
Timothy R Smyth,Stephanie Brocke,Weidong Wu et al.
Timothy R Smyth et al.
Macrophages are key innate immune cells which exist on a spectrum between pro-inflammatory (M1) and pro-resolutory (M2) states while retaining the ability to reprogram following exposure to new stimuli. Particulate matter (PM) exposure sign...
High-concentration MEHP triggers mtDNA depletion in undifferentiated HepaRG and C2C12 cultures and disrupts mitochondrial homeostasis in both HepaRG culture states [0.03%]
高浓度MEHP诱导未分化HepaRG和C2C12细胞系中线粒体DNA耗竭，并破坏两种培养状态下HepaRG的线粒体稳态
Md Mostafijur Rahman,Pabitra Khadka,Carolyn K J Young et al.
Md Mostafijur Rahman et al.
Phthalates are often called "everywhere chemicals" because they are widely used in consumer products and are detectable in the environment and humans. One of the most studied phthalates, di-2-ethylhexyl phthalate (DEHP), is metabolized to m...
Omeprazole activation of CD4+ and CD8+ T-cells through off-target covalent modification of cellular proteins [0.03%]
奥美拉唑通过脱靶共价修饰细胞蛋白激活CD4⁺和CD8⁺T细胞
Sophie Grice,Sa&#x;d Albashtawy,Georgia Wells et al.
Sophie Grice et al.
Targeted covalent inhibition of protein function is increasingly used as a therapeutic mode of action; however, there is a need to characterize off-target binding interactions and to understand whether this represents an immunological risk....
Emergent latent neurotoxic effects of manganese following nominal chronic exposures in human stem cell and Caenorhabditis elegans models [0.03%]
基于人类干细胞和秀丽隐杆线虫模型的锰慢性暴露后产生的潜在神经毒性效应
Xueqi Tang,Airton C Martins,Anke M Tukker et al.
Xueqi Tang et al.
Behavioral deficits can emerge after the removal of manganese (Mn) exposures in humans and other mammals. Although epidemiological studies provide substantial evidence supporting latency, challenges reproducing such effects in alternative m...
An environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages [0.03%]
一组环境相关的有机磷酸酯混合物可在THP-1型巨噬细胞中诱导胆固醇生物合成
Braeden H Giles,Bernard Robaire,Koren K Mann
Braeden H Giles
Organophosphate esters (OPEs), widely used as flame retardants and plasticizers, are environmental toxicants known to disrupt lipid metabolism. Although most studies have focused on individual OPEs, environmental exposures typically involve...
Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA [0.03%]
基于HFPO-DA机制和重复给药毒性数据的口服参考剂量推导集成
Chad M Thompson,Melissa M Heintz,Sarah I Rogers et al.
Chad M Thompson et al.
HFPO-DA (ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate) is a short-chain perfluoroether carboxylic acid used as a polymerization aid in the manufacture of some types of fluorinated polymers. Existing toxicity criteria for H...