How pH and sulfation shape human heparanase structure, stability, and substrate recognition [0.03%]
PH和硫酸盐对人类肝素酶结构、稳定性和底物识别的影响
Angela Pennacchio,Yesid Aristizabal,José Oñate-Garzón et al.
Angela Pennacchio et al.
Human heparanase (HPSE) is an endo-β-d-glucuronidase involved in the degradation of heparan sulfate and in several physiopathological processes, including inflammation, metastasis, and extracellular matrix remodeling. Its activity is stron...
PTBP1 promotes coronary artery calcification by regulating CARD8 alternative splicing and NLRP3 inflammasome activation [0.03%]
PTBP1通过调节CARD8可变剪接和NLRP3炎性小体激活促进冠状动脉钙化
Hao Hu,Fan Zhang,Jun Wu et al.
Hao Hu et al.
Background: Coronary artery calcification (CAC) serves as a significant predictor of cardiovascular events; however, its underlying molecular mechanisms remain incompletely elucidated. PTBP1, an RNA-binding protein with p...
Effect of calcium and cholesterol on membrane binding and localization of the S100A16 protein [0.03%]
钙和胆固醇对S100A16蛋白膜结合及定位的影响
Francis Noël,Stefan W Vetter,Elodie Boisselier
Francis Noël
Maintaining the structural and functional integrity of cellular membranes is essential for proper cells function. A recent proteomic study suggests that the S100A16 protein may contribute to the maintenance of membrane integrity in the rod ...
MiR-144-3p enhances cisplatin sensitivity in triple-negative breast cancer by targeting SLC7A11 to induce ferroptosis [0.03%]
miR-144-3p通过靶向SLC7A11诱导铁死亡从而增强三阴性乳腺癌细胞对顺铂的敏感性
Rui Tian,Mancheng Yu,Hongtao Cheng
Rui Tian
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype in which resistance to cisplatin (cis-diamminedichloroplatinum II, CDDP) limits therapeutic efficacy, and ferroptosis has emerged as a key determin...
The coordinated regulation of CASC2/miR-200c/miR-20b and SIRT1/ACE-2/IL-6 Axes in COVID-19 pneumonia: Novel molecular diagnostic and therapeutic insights [0.03%]
CASC2/miR-200c/miR-20b和SIRT1/ACE-2/IL-6轴在新型冠状病毒肺炎中的协同调控：新的分子诊断与治疗启示
Ghada Ayeldeen,Olfat G Shaker,Mona Ibrahim Ahmed et al.
Ghada Ayeldeen et al.
Pneumonia is an acute lung tissue infection that may be induced by various agents, like SARS-CoV-2 virus. The ongoing research focused on the molecular interplay between the lncRNA CASC2 and the miR-200c and miR-20b in tuning SIRT1 and ACE2...
Structural and mechanistic insights into Edo4, an extradiol dioxygenase in dioxin degradation [0.03%]
有关表氯代二𫫇英降解的外环氧酶Edo4的结构和机理研究
Arpan Kayastha,Kuldeep Jangid,Shalja Verma et al.
Arpan Kayastha et al.
Extradiol dioxygenases (EDOs) are integral ring-cleaving enzymes that bridge the catabolic pathways between dioxygenase and hydrolase enzymes. However, the structural basis for substrate recognition and active site access in EDOs of the dio...
Biochemical and biophysical characterization of a cold-active yet highly thermostable manganese superoxide dismutase (CsMnSOD) from Camellia sinensis [0.03%]
茶树冷活性且高度耐热的锰超氧化物歧化酶(CsMnSOD)的生化和生物物理特性表征
Mahima Chauhan,Himanshu,Vijay Kumar Sharma et al.
Mahima Chauhan et al.
Manganese superoxide dismutase (MnSOD) functions as a vital mitochondrial antioxidant enzyme responsible for the detoxification of superoxide radicals (O2•-). Recent studies have proposed that MnSOD may have dual role, serving not only as ...
Targeting AURKA by MiR-490-3p Overcomes Paclitaxel Resistance in Oral Squamous Cell Carcinoma via NF-κB/STAT3 Signaling [0.03%]
MiR-490-3p靶向AURKA通过NF-κB / STAT3信号通路克服口腔鳞状细胞癌的紫杉醇耐药性
Linfu Han,Liwei Peng,Xiqian Wang et al.
Linfu Han et al.
Background: Paclitaxel (PTX) resistance remains a major barrier to effective treatment of oral squamous cell carcinoma (OSCC). Although Aurora kinase A (AURKA) has been implicated in tumor progression, its functional role...
Molecular and Functional Consequences of the Cdc42 C81Y Mutation in Immune-associated Malignancy [0.03%]
免疫相关肿瘤中Cdc42C81Y突变的分子与功能影响
Chien Fung Chong,Syafinaz Amin Nordin,Saiful Effendi Syafruddin et al.
Chien Fung Chong et al.
Cell division control protein 42 homolog (Cdc42) is a small Rho GTPase that cycles between active GTP-bound and inactive GDP-bound states to regulate cytoskeletal dynamics and immune signalling. Pathogenic variants of Cdc42 have been linked...
Purification and characterization of a peroxidase from Calotropis procera latex and its distinct role from anthelmintic proteins [0.03%]
Calotropis procera乳胶过氧化物酶的纯化、鉴定及其与驱虫蛋白的不同作用特点
Cleverson D T Freitas,Márcio V Ramos,Yandra T R Mota et al.
Cleverson D T Freitas et al.
This study reports the proteomic analysis of C. procera latex, as well as the identification, purification, and partial characterization of an unusual peroxidase (CpLP-POX). Initially, the proteomic analysis revealed typical defense-related...