Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations [0.03%]
2型糖尿病对脂蛋白颗粒表面脂质及生物物理性质的影响
Ana Reis,Ana Rita D Araújo,Irundika H K Dias et al.
Ana Reis et al.
Surface lipids in lipoproteins interact with proteins and receptors at the surface of cell membranes, mediating lipoprotein-cell signaling and trafficking events. Despite this, little is known about lipoproteins' surface lipid composition a...
Structural, dynamic, and evolutionary determinants of substrate binding in the tetrameric 6-phosphogluconate dehydrogenase from Gluconobacter oxydans [0.03%]
葡萄糖氧化菌六磷酸葡萄糖脱氢酶底物结合的结构、动态及进化决定因素
Pablo Maturana,Pablo Villalobos,Pietro Roversi et al.
Pablo Maturana et al.
6-Phosphogluconate dehydrogenases (6PGDHs) catalyze a key oxidative step in the oxidative pentose phosphate pathway (oxPPP), a route essential for NAD(P)H generation and carbon metabolism in bacteria and eukaryotes. While the structural bas...
Tangzhiwan Pills (TG) Ameliorate Type 2 Diabetes by Restoring Hepatic Glycolysis/Gluconeogenesis via the PPAR Signaling Pathway [0.03%]
唐栀丸通过PPAR信号通路恢复肝脏糖异生/糖酵解从而改善2型糖尿病的作用研究
Qin Li,Xuan Liu,Lulu Xiao et al.
Qin Li et al.
Background: Type 2 diabetes mellitus (T2DM) is a global health challenge associated with significant morbidity and mortality. Previous studies have indicated that the traditional Chinese medicine formula Tangzhiwan pills ...
Melike Can,Hande Basırlı,Volkan Seyrantepe
Melike Can
Neuraminidases are crucial enzymes that cleave terminal sialic acid residues from sialylated glycoconjugates. Their presence varies across tissues, cellular locations, and substrate specificities in different mammalian species, assigning ea...
RHBDD1 promotes cervical cancer progression by activating the EGFR/PI3K/AKT signaling pathway [0.03%]
RHBDD1通过激活EGFR/PI3K/AKT信号通路促进宫颈癌进展
Wei Li,Xin Liang,Xiurong Wu et al.
Wei Li et al.
Background: Although RHBDD1 has been linked to tumorigenesis, its specific role in cervical cancer (CC) remains elusive. This study investigated its oncogenic function and regulatory mechanism in CC cells. ...
Phosphocreatine attenuates isoproterenol-induced cardiac fibrosis via activation of the Nrf2/ARE antioxidant pathway and preservation of endothelial integrity [0.03%]
磷Creatine通过激活Nrf2 / ARE抗氧化途径和保持内皮完整性来缓解异丙肾上腺素诱导的心脏纤维化
Wu Liu,Eskandar Qaed,Waleed Aldahmash et al.
Wu Liu et al.
Background: Phosphocreatine (PCr), a high-energy phosphate donor with established cytoprotective and antioxidative properties, is known to support endothelial function. However, its role in the regulation of cardiac fibro...
Comparison of bioavailability of quercetin and its structural analogs in mice [0.03%]
鼠模型中槲皮素及其结构类似物的生物利用度比较研究
Nozomi Maeda,Atsushi Hashimoto,Ryosei Morita et al.
Nozomi Maeda et al.
Flavonoids are thought to provide beneficial effects on health. However, there are still uncertainties regarding their bioavailability. In this study, we investigated the bioavailability of 6 flavonoids, galangin, kaempferol, quercetin, myr...
Advanced glycation end product-its receptor axis participates in myoblast senescence in vitro and delayed muscle regeneration of senescence/aging skeletal muscles in vivo [0.03%]
晚期糖基化终产物及其受体轴参与体外肌母细胞衰老及体内衰老肌肉再生延迟
Ding-Cheng Chan,Jia-Hua Jhuang,Fang-Yu Chang et al.
Ding-Cheng Chan et al.
The global population is rapidly aging, leading to a significant increase in age-related diseases in the coming years. Muscle dysfunction is a prevalent chronic condition among older adults, posing significant public health challenges. One ...
The influence of UV filters (Oxybenzone and Avobenzone) on lipid monolayers, with consideration of the role of lipid structure and monolayer composition [0.03%]
考虑脂质结构和单层组成的作用的UV滤光片(氧苯酮和阿伏苯宗)对脂质单分子层的影响
Beata Wyżga,Karolina Olechowska,Magdalena Skóra et al.
Beata Wyżga et al.
The widespread use of UV filters and their release into the environment raise concerns due to their potential harmful effects on living organisms. Consequently, the toxicity and bioaccumulation capacity of UV filters are currently the subje...
EGFR and IRE1α pathways are associated with distinct immunomodulatory gene expression profiles in NSCLC cells with acquired resistance to EGFR TKIs [0.03%]
EGFR和IRE1α通路与获得性EGFR TKIs耐药NSCLC细胞中不同的免疫调节基因表达特征相关
Yi-Shiuan Wang,Hsiu-Chuan Chou,En-Chi Liao et al.
Yi-Shiuan Wang et al.
EGFR-TKI-resistant cell lines were established by long-term exposure to gefitinib, afatinib, and osimertinib via the PC9 model. This model helps study EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) and may offer insigh...