AEBP1 targets DDR2 to induce ferroptosis and microglial activation through the STAT3/P53 signaling pathway, exacerbating depression risk [0.03%]
AEBP1通过STAT3/P53信号通路靶向DDR2诱导铁死亡和小胶质细胞活化，以加剧抑郁风险
Qing Zou,Zijian Zeng,Yue Wan et al.
Qing Zou et al.
This study investigated the role of Discoidin Domain Receptor 2 (DDR2) in depressive behavior, neuroinflammation, and ferroptosis in the Chronic Unpredictable Mild Stress (CUMS) mouse model, as well as its regulatory mechanisms in LPS-induc...
Mechanism of vascular endothelial growth factor regulating hypoxia and inflammatory microenvironment in endometriosis: based on bioinformatics and multi-level validation [0.03%]
血管内皮生长因子调节子宫内膜异位症缺氧及炎性微环境的机制研究：基于生物信息学和多水平验证
Weichang Yu
Weichang Yu
Endometriosis remains a prevalent gynecological disorder that affects women during their reproductive years, featured by progressive inflammation and enhanced HIF-1α expression. This paper intended to plumb the mechanism of vascular endoth...
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII [0.03%]
运动通过脂肪组织来源的含miR-17-3p的小胞外囊泡靶向抑制CaMKII来缓解心肌缺血再灌注损伤所导致的程序性坏死
Zhuyuan Liu,Wenbin Lu,Yanru He et al.
Zhuyuan Liu et al.
Exercise exerts cardioprotective effects, with prior research implicating exosomal miR-17-3p as a critical mediator in attenuating myocardial ischemia-reperfusion injury (MIRI). The present study aimed to elucidate the influence of exercise...
A novel tRNA-Derived Fragment, tRF-23-Z87HFK8SDZ inhibits malignant progression of pancreatic cancer through mediating IRS1 [0.03%]
一种新型tRNA衍生片段tRF-23-Z87HFK8SDZ通过介导IRS1抑制胰腺癌的恶性进展
Liping Zheng,Jing Wang,Yiyu Shen et al.
Liping Zheng et al.
Background: Transfer RNA-derived fragments (tRFs) have emerged as significant actors in cancer progression. Nevertheless, their functions in pancreatic cancer stay poorly understood. This work focuses on the role of tRF-2...
Thermodynamics of the transition from the ferryl (F) state to the oxidized form of the solubilized cytochrome c oxidase: implication for the proton pumping [0.03%]
关于细胞色素c氧化酶溶解态的铁矾(F)型向氧化型转变的热力学：对质子泵动力学的意义
Adriana Tomkova,Tereza Sztachova,Jonatan Johannesson et al.
Adriana Tomkova et al.
Two ferryl intermediates have been identified in the membrane-bound respiratory heme-copper oxygen reductases (HCOs) during reduction of O2 to water. Apparently, energy released by reduction of these two ferryl forms is utilized to build th...
Novel epigenetic biomarkers following ferroptosis and pyroptosis in a hypobaric hypoxia-induced renal injury model [0.03%]
低氧诱导的肾脏损伤模型中铁死亡和炎性细胞焦亡的新表观遗传学生物标志物
Hongxuan Liu,Huishu Lin,Yuhong He et al.
Hongxuan Liu et al.
Background: Rapid hypobaric hypoxia exposure damages oxygen-sensitive organs like the kidneys. Ferroptosis and pyroptosis, oxygen-dependent cell death mechanisms, remain understudied in this context, as does the role of m...
MITOCHONDRIAL REDOX IMBALANCE AND CoQ10 DEFICIENCY IN RETT SYNDROME: INSIGHTS FROM PATIENT-DERIVED FIBROBLASTS [0.03%]
雷特综合征的线粒体氧化还原失衡和辅酶Q10缺乏：来自患者成纤维细胞的启示
Francesco Mengarelli,Valeria Cordone,Alessandra Pecorelli et al.
Francesco Mengarelli et al.
Rett syndrome (RTT), a neurodevelopmental disorder primarily affecting females, is characterized by mutations in the MECP2 gene, leading to systemic oxidative stress and mitochondrial dysfunction. This study investigates the role of Coenzym...
Lauryl gallate induces apoptosis via p38-MAPK phosphorylation and autophagy in chemoresistant human lung cancer cells [0.03%]
月桂棓酸盐通过p38 MAPK磷酸化和自噬诱导化学抗性人肺癌细胞凋亡
Yen-Hsiang Huang,Shur-Hueih Cherng,Ling-Yen Chiu et al.
Yen-Hsiang Huang et al.
Human lung cancer has taken many lives and chemoresistance generally occurs in patients and reduces patients' survival. Docetaxel (DOC) and vincristine (VCR) have been widely used in cancer chemotherapy but their efficacy is restricted by P...
Study of the antibacterial peptide P8.1: Effect on anionic vesicles using spectroscopic techniques [0.03%]
抗菌肽P8.1对阴离子小泡作用的光谱学研究
Luis Emanuel Jimenez,Rosa M S Álvarez,Paulo Maffia et al.
Luis Emanuel Jimenez et al.
Antimicrobial peptides (AMPs) are promising complements to antibiotics, yet their membrane-level actions remain incompletely understood. In this work, we characterized how the "de novo" cationic AMP P8.1 interacts with anionic lipid bilayer...
Swapped domain orders in ZO-1 PDZ3 fusion proteins - implications for binding of established and novel targets [0.03%]
ZO-1 PDZ3融合蛋白中的域顺序交换及其对已知和新型靶分子结合的影响
Marie Hamsikova,Jan Hurdalek,Leandro Simonetti et al.
Marie Hamsikova et al.
PDZ domains play key roles in mediating protein-protein interactions by recognizing short PDZ-binding motifs, typically at the C-termini of target proteins. Zonula occludens 1 (ZO-1) is a scaffolding protein that links tight junction protei...