An inclusive outlook on the fate and persistence of pesticides in the environment and integrated eco-technologies for their degradation [0.03%]
包容性的环境视角及整合生态技术在农药降解中的应用
Yogesh S Chaudhari,Pankaj Kumar,Sunil Soni et al.
Yogesh S Chaudhari et al.
Intensive and inefficient exploitation of pesticides through modernized agricultural practices has caused severe pesticide contamination problems to the environment and become a crucial problem over a few decades. Due to their highly toxic ...
Potential cardioprotective and anticancer effects of carvedilol either free or as loaded nanoparticles with or without doxorubicin in solid Ehrlich carcinoma-bearing mice [0.03%]
卡维地洛或其载药纳米粒单独使用或与多柔比星联用对携带实体艾氏腹水癌小鼠的潜在心保护及抗肿瘤作用
Amr Zidan,Amira A El Saadany,Gamal M El Maghraby et al.
Amr Zidan et al.
Aim: The aim of this study was to investigate the potential cardioprotective and anti-cancer effects of carvedilol (CAR) either free or as loaded nano-formulated with or without doxorubicin (DOX) in solid Ehrlich carcinom...
Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats [0.03%]
在大鼠体内暴露于高浓度的新戊二醇酞酸酯（DINP）可降低胎儿睾丸素和INSL3的生物相关水平
L Earl Gray Jr
L Earl Gray Jr
Some phthalate esters alter male rat reproductive development during sexual differentiation by interfering with fetal testis maturation resulting in reduced Leydig Cell synthesis of testosterone and insulin-like 3 (Insl3) hormones. Gene tra...
Applications of promiscuity of FDA-approved kinase inhibitors in drug repositioning and toxicity [0.03%]
美国食品药品管理局已批准的激酶抑制剂泛用性在药物再定位和毒性中的应用
Meghana Korikani,Neeshat Fathima,Gouthami Nadiminti et al.
Meghana Korikani et al.
Promiscuity of therapeutics has important implications in treatment and toxicity. So far, a comprehensive understanding of promiscuity related to kinase inhibitors is lacking and such an analysis may offer potential opportunities for drug r...
Functional and targeted proteomics characterization of a human primary endothelial cell model of the blood-brain barrier (BBB) for drug permeability studies [0.03%]
人源性原代内皮细胞血脑屏障模型的功能和目标蛋白质组表征，用于药物渗透研究
David Gomez-Zepeda,Nicolas Perrière,Fabienne Glacial et al.
David Gomez-Zepeda et al.
The blood-brain barrier (BBB) protects the brain from toxins but hinders the penetration of neurotherapeutic drugs. Therefore, the blood-to-brain permeability of chemotherapeutics must be carefully evaluated. Here, we aimed to establish a w...
Methamphetamine induces cardiomyopathy through GATA4/NF-κB/SASP axis-mediated cellular senescence [0.03%]
甲基苯丙胺通过GATA4/NF-κB/SASP轴介导的细胞衰老诱导心肌病
Xu Zhao,Jiancong Lu,Cui Zhang et al.
Xu Zhao et al.
With the world pandemic of methamphetamine (METH), METH-associated cardiomyopathy (MAC) has become a widespread epidemic and is also recognized as a cause of heart failure in young people. The mechanism of occurrence and development of MAC ...
In vitro and in vivo anti-tumor activity of Coenzyme Q0 against TWIST1-overexpressing HNSCC cells: ROS-mediated inhibition of EMT/metastasis and autophagy/apoptosis induction [0.03%]
辅酶Q0对TWIST1高表达的头颈部鳞状细胞癌细胞的体内外抗肿瘤活性：通过ROS介导的EMT/m转移抑制和自噬/凋亡诱导作用
Hsin-Ling Yang,Li-Wen Chiu,Yi-An Lin et al.
Hsin-Ling Yang et al.
HNSCC (Head and Heck Squamous Cell Carcinoma) is a reasonably prevalent cancer with a high mortality rate. In this study, we tried to examine the anti-metastasis and apoptosis/autophagy actions of Coenzyme Q0 (CoQ0, 2,3-dimethoxy-5-methyl-1...
Transcriptomic profiling and differential analysis reveal the renal toxicity mechanisms of mice under cantharidin exposure [0.03%]
转录组分析揭示斑马鱼和小鼠蝉蜕cantharidin暴露的肾脏毒性机制
Xin Liu,Linghan Zhang,Wenchao Tang et al.
Xin Liu et al.
Cantharidin (CTD), extracted from the traditional Chinese medicine mylabris, has shown significant curative effects against a variety of tumors, but its clinical application is limited by its high toxicity. Studies have revealed that CTD ca...
Designer benzodiazepine rat pharmacokinetics: A comparison of alprazolam, flualprazolam and flubromazolam [0.03%]
新型苯二氮卓类药物的设计：阿尔普唑仑、氟丙匹酯和氟溴西泮的药动学对比研究
Jeremy R Canfield,David F Kisor,Jon E Sprague
Jeremy R Canfield
Designer benzodiazepines, including flualprazolam and flubromazolam, are clandestinely produced to circumvent federal regulations. Although flualprazolam and flubromazolam are structurally similar to alprazolam, they do not have an approved...
Resolution of inflammation in xenobiotic-induced mucosal injury and chronic disease [0.03%]
外源物质引起的粘膜损伤和慢性疾病炎症的消退
Kymberly M Gowdy,Debra L Laskin
Kymberly M Gowdy
It has been appreciated for decades that exposure to toxicants can induce injury and inflammation leading to multiple pathologies in many organ systems. However, recently the field has begun to recognize that toxicants can cause chronic pat...