Angelicin attenuates sepsis-associated splenic injury by targeting NF-κB/JAK2/STAT3 and PI3K/Akt pathways to inhibit inflammation and apoptosis [0.03%]
天使素通过靶向NF-κB / JAK2 / STAT3和PI3K / Akt途径抑制炎症和凋亡来缓解脓毒症相关的脾损伤
Enzhuang Pan,Huilin Sun,Zhihao Ma et al.
Enzhuang Pan et al.
Sepsis represents a clinical syndrome characterized by maladaptive host immune dysregulation in response to infection, leading to potentially fatal multiorgan dysfunction. As the largest secondary lymphoid organ in mammals, spleen tissue pl...
Transcription factor TFAP2A drives EMT progress by activating BDKRB1 transcription: The potential mechanism by which TFAP2A promotes idiopathic pulmonary fibrosis [0.03%]
转录因子TFAP2A通过激活BDKRB1转录驱动上皮间质转化：TFAP2A促进特发性肺纤维化的潜在机制研究
Jingwen Zhang,Xin Jin,Yajiao Sun et al.
Jingwen Zhang et al.
Epithelial-mesenchymal transition (EMT)-inducing signals trigger the accumulation of extracellular matrix, thereby contributing to organ pathology, including idiopathic pulmonary fibrosis (IPF). Transcription factor AP-2 alpha (TFAP2A) has ...
Expression of drug transporters in human allogenic transplanted kidneys in acute rejection [0.03%]
急性排异反应中人同种异体移植肾的药物转运蛋白表达
J Łapczuk-Romańska,J Hybiak,K Piotrowska et al.
J Łapczuk-Romańska et al.
Kidney drug transporters, primarily located in the basolateral and apical membranes of proximal tubule cells, play a key role in the secretion and reabsorption of drugs and endogenous compounds. Recent studies have demonstrated that kidney ...
Cardamonin attenuates osteoporosis progression and promotes osteogenic differentiation of bone mesenchymal stem cells by upregulating TCF4 expression [0.03%]
姜黄素诱导的TCF4上调对骨髓间充质干细胞成骨分化的促进作用及对骨质疏松症发展的抑制作用研究
Haizhong Sun,Runwu Hu,Jianlong Wu
Haizhong Sun
Background: Osteoporosis is a common skeletal metabolic disorder. Cardamonin (CAR) is a natural chalcone compound with multiple activities. However, the role and mechanism of CAR in osteoporosis progression remain largely...
Identification of key targets and mechanisms of isoorientin in osteoporosis treatment through integrated network pharmacology and experimental validation [0.03%]
整合式网络药理学与实验验证鉴定异 orientin 治疗骨质疏松症的关键靶点和机制
Jinku Guo,Jun Xie,Ankai Xu et al.
Jinku Guo et al.
Osteoporosis is a prevalent metabolic bone disorder characterized by diminished bone mineral density and elevated fracture susceptibility. Although isoorientin (ISO) has emerged as a promising candidate for osteoporosis treatment, its molec...
Nab-paclitaxel inhibits angiogenesis via the CYR61/integrin αvβ3 Axis: Exosomal proteomics insights into breast cancer chemoprevention [0.03%]
纳米白蛋白结合紫杉醇通过CYR61/整合素αvβ3轴抑制血管生成：乳腺癌化学预防的外泌体蛋白质组学见解
Yi Zhang,Jiajun Wang,Zhongjie Deng et al.
Yi Zhang et al.
Albumin-bound paclitaxel (Nab-PTX), a nanoparticle albumin-bound formulation in which paclitaxel is conjugated to human serum albumin, has emerged as a pivotal agent in cancer therapy. Its significance stems not only from direct cytotoxic e...
Cyclomulberrin represses renal cell carcinoma progression via ferroptosis activation [0.03%]
cyclomulberrin通过激活铁死亡抑制肾细胞癌进展
Xinyu Yi,Zhixuan Xie,Taian Jin et al.
Xinyu Yi et al.
Renal cell carcinoma (RCC) is one of the most common malignancies in the genitourinary system. Cyclomulberrin (CyM), a natural prenylated flavonoid, has shown anti-tumor potential. However, the efficacy and potential mechanisms of this trea...
Potassium channel tetramerization domain-containing 10 exerts a tumor suppressive function in breast cancer by destabilizing SLC7A11 to induce ferroptosis [0.03%]
钾通道四聚体结构域蛋白10通过使SLC7A11不稳定从而诱导铁死亡而在乳腺癌中发挥抑癌作用
Xin He,Ying Wang,Dan Wang et al.
Xin He et al.
Potassium channel tetramerization domain-containing 10 (KCTD10) plays a crucial role in the progression of various tumors. However, comprehensive studies on the involvement of KCTD10 in breast cancer are still lacking. This research aims to...
Sustained cadmium exposure and hyperglycemia additively drives mitochondrial dysfunction in hepatic cells: Implications for MASLD etiopathogenesis [0.03%]
持续的镉暴露和高血糖会协同驱动肝细胞线粒体功能障碍：对MASLD发病机制的意义
Rahul Kumar,Ashwin Chinala,Sharina Desai et al.
Rahul Kumar et al.
Effects of chronic heavy metal stress on hepatocellular pathophysiology remains ill-understood. Human livers are a long-term accumulative site for many toxic heavy metals (e.g., cadmium and arsenic) whose health effects are unknown. In the ...
EP300 promotes cervical cancer progression through a Wnt/β-catenin-dependent HIF-1α signaling axis [0.03%]
EP300通过Wnt/β-catenin依赖的HIF-1α信号轴促进宫颈癌进展
Yue Zhang,Yongxin Zhang,Ke Wang
Yue Zhang
This study aimed to investigate the role of EP300 in cervical cancer progression, focusing on its functional effects related to pyroptosis under Wnt/β-catenin-dependent conditions. In SiHa and HeLa cells, EP300 was silenced using lentivira...