Levistolide A induces endoplasmic reticulum stress-triggered apoptosis via ATF6 in triple-negative breast cancer [0.03%]
莱维斯托利德A通过ATF6诱导三阴性乳腺癌内质网应激介导的凋亡作用
Yitian Bai,Dandan Wang,Hantian Guan et al.
Yitian Bai et al.
Background: Levistolide A(LA), a bioactive constituent extracted from the herbal plant Ligusticum chuanxiong possesses anticancer properties. Nevertheless, its functions and underlying processes in triple-negative breast ...
Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner [0.03%]
磷乙醇胺胞苷酸转移酶2通过调节PPP2R1A依赖的Hippo/YAP1信号通路在透明细胞肾细胞癌中发挥抑瘤作用
Ning Nan,Hao Guo,Yan Huang et al.
Ning Nan et al.
Recent studies have indicated that phosphoethanolamine cytidylyltransferase 2 (PCYT2) is aberrantly expressed in various tumors, influencing tumor progression, metastasis, and drug resistance. However, the role of PCYT2 in clear cell renal ...
Dermorphin blocks apneic response to intravenous bolus injection of fentanyl [0.03%]
德摩灵可阻断喷他佐辛引起的呼吸抑制作用
Jianguo Zhuang,Xiuping Gao,Shan Shi et al.
Jianguo Zhuang et al.
Background: Sudden death induced by intravenous bolus (IVb) injection of overdose fentanyl is the major cause of overdose opioid-induced deaths; however, the relevant countermeasure is lacking. IVb injection of overdose f...
Unraveling the connection between PFOA and bladder cancer: A study integrating network toxicology, molecular docking, and experimental validation [0.03%]
PFOA与膀胱癌关联性的研究：整合网络毒理学、分子对接和实验验证
Huaqing Yan,Chunyan Yin,Fan Xu et al.
Huaqing Yan et al.
PFOA, an environmental pollutant linked to bladder cancer, has unclear molecular mechanisms. Integrating transcriptomic data with network toxicology and machine learning, we identified 125 shared genes related to PFOA and bladder cancer. Ma...
Boji Wu,Tingting Tian,Yuxiang Liu et al.
Boji Wu et al.
Lactate produced during glycolysis plays a critical role in pulmonary arterial hypertension (PAH) by mediating protein lactylation and other molecular effects. Targeting lactylation-related signaling holds significant promise for the treatm...
Evaluation of liver toxicity in rats exposed to silver nanoparticles - Targeted metabolomics and histology based study [0.03%]
基于靶向代谢组学和组织学的银纳米颗粒肝毒性评价研究
Su Rui,Wang Yueyang,Han Zezhou et al.
Su Rui et al.
Silver nanoparticles (AgNPs) while providing beneficial applications may also pose risks, making it essential to investigate their potential toxicity in living systems. In this study, we examined the impact of Ag NPs on the liver metabolome...
MiR-29a/DNMT3A axis participates in Dihydroartemisinin's suppression on lung adenocarcinoma: Implications for overcoming acquired resistance to EGFR-TKIs [0.03%]
微RNA-29a/DNA甲基转移酶3A轴参与双氢青蒿素对肺癌的抑制：克服表皮生长因子受体酪氨酸激酶抑制剂获得性耐药的意义
Yayu Zhu,Ping Qiu,Jing Tang et al.
Yayu Zhu et al.
Dihydroartemisinin (DHA), the traditional antimalarial agent, has attracted significant interest as potential anticancer drug, yet its underlying mechanisms are incompletely understood. Herein, we showed that DNA methyltransferase 3 alpha (...
Clarification on the interpretation of TCGA-SARC data in the prognostic evaluation of MMP13 in osteosarcoma [0.03%]
TCGA-SARC数据中MMP13在骨肉瘤预后评估解读的澄清
Jiro Ichikawa,Masanori Wako,Tomonori Kawasaki
Jiro Ichikawa
Lysine succinylation-mediated energy metabolism imbalance drives brain injury in acute diquat poisoning [0.03%]
急性灭草剂二奎普中毒引起大脑损伤的分子机制研究进展
Chaocheng Wang,Haiqun Yang,Zhiyu Wang et al.
Chaocheng Wang et al.
Neurological damage induced by diquat (DQ) poisoning has garnered significant attention from researchers in recent years. This study represents the first systematic investigation into the molecular mechanisms underlying acute DQ-induced bra...
Editorial: In memoriam Dr. Michael Phillip Waalkes-Advances in inorganic carcinogenesis, metal toxicity and stem cell toxicology [0.03%]
纪念迈克尔·菲利普·瓦尔克斯博士——无机致癌、金属毒性及干细胞毒理学研究进展
Erik J Tokar,Lamia Benbrahim-Tallaa,William E Achanzar et al.
Erik J Tokar et al.