Dose-dependent modulation of mitochondrial physiology and nutrient secretion in Sertoli cells by l-carnitine [0.03%]
L-肉毒碱对sertoli细胞线粒体生理功能的剂量依赖性调节及其营养物质分泌作用
Filipa G Mateus,Ana D Martins,Silvia Moreira et al.
Filipa G Mateus et al.
l-Carnitine is a ubiquitous quaternary amine, essential for the mitochondrial β-oxidation of long-chain fatty acids, and a dietary supplement widely consumed by athletes due to its purported ergogenic and recovery-enhancing properties. Bey...
Etanercept suppresses rheumatoid arthritis development via modulating miR-125a-3p [0.03%]
依那西普通过调控miR-125a-3p抑制类风湿关节炎发病
Yingxue Wang,Zhe Yin,Zhilun Wang et al.
Yingxue Wang et al.
Although etanercept is effective in managing inflammatory disorders, its precise anti-inflammatory mechanisms remain unclear. This study explored its therapeutic benefits in rheumatoid arthritis (RA) by focusing on the modulation of miR-125...
Corynoxine suppresses hepatocellular carcinoma progression by forming the ROS-STAT3 cycle [0.03%]
猫眼素通过形成ROS-STAT3环抑制肝癌进展
Chunmei Wen,Mengyao Wang,Yitian Yu et al.
Chunmei Wen et al.
Hepatocellular carcinoma (HCC) is a type of highly prevalent malignancy characterized by poor prognosis and high rates of recurrence and metastasis. Corynoxine (Cory), a natural alkaloid extracted from Uncaria rhynchophylla, has been identi...
Magnesium sulfate attenuates sepsis-induced myocardial injury through macrophage Fxyd2/NF-κB signaling: Integrated evidence from a propensity-matched cohort, single-cell atlas, and mechanistic validation [0.03%]
硫酸镁通过巨噬细胞Fxyd2/NF-κB信号通路减轻脓毒症诱导的心肌损伤：来自倾向匹配队列、单细胞图谱和机制验证的综合证据
Dongxia Xu,Yucheng Zhou,Yimeng Li et al.
Dongxia Xu et al.
Background: Sepsis-induced myocardial injury (SIMI) affects approximately 20%-55% of septic patients, with associated mortality ranging from 37% to 70%; however, evidence for magnesium sulfate (MgSO₄) as a targeted SIMI ...
Highly efficient discovery of CYP1B1 inhibitors from licorice as novel anti-fibrotic agents via integrating interdisciplinary methodologies [0.03%]
基于多学科交叉研究的甘草来源CYP1B1抑制剂的高效发现及其抗纤维化活性研究
Ziwei Li,Yumeng Hao,Ya Yang et al.
Ziwei Li et al.
Aberrant CYP1B1 activity has been implicated in various metabolic disorders, while targeted inhibition on CYP1B1 has been validated as an emerging therapeutic strategy for hepatic fibrosis. Although a range of edible herbs including Licoric...
Growth-mode-independent glutamine/glutamate/aspartate metabolic shift and urea cycle remodeling driven by FOXA1 in benzo[a]pyrene-transformed human bronchial epithelial cells [0.03%]
芳族烃受体易位蛋白驱动的FOXA1诱导的环芳烃转化人支气管上皮细胞中与生长模式无关的谷氨酰胺/谷氨酸/天冬氨酸代谢转换及尿素循环重构
Yujin Fu,Yanmin Qi,Yunkun Xing et al.
Yujin Fu et al.
To characterize the amino acid metabolic remodeling in THBEc1 cells malignantly transformed by benzo[a]pyrene (BaP) relative to parental human bronchial epithelial HBE cells, and to delineate the role of FOXA1 in this remodeling, the amino ...
Advanced glycation end products promote diabetic retinopathy through the p65-p300/SMAD4-miR-409-5p-HIF-1α-VEGF signaling pathway [0.03%]
晚期糖基化终末产物通过p65-p300/SMAD4-miR-409-5p-HIF-1α-VEGF信号通路促进糖尿病视网膜病变
Jingyu Liu,Xiaomin Zhang,Xin Qi et al.
Jingyu Liu et al.
Diabetic retinopathy (DR) is a major complication of diabetes, with advanced glycation end products (AGEs) implicated in its pathogenesis, although the underlying mechanisms remain unclear. This study investigated the role of AGEs in DR usi...
In-depth in vivo and in vitro investigation of metabolism and detectability of three novel methylprolintane psychostimulants by hyphenated mass spectrometry [0.03%]
新型甲基普兰丁三类心理刺激剂体内和体外代谢及检测的深入研究——串联质谱法
Lea Wagmann,Anica Herter,Michael B Dybek et al.
Lea Wagmann et al.
Amphetamine-type stimulants (ATS) remain a major group among internationally misused psychostimulants. Prolintane (1-(1-phenylpentan-2-yl)pyrrolidine) is one representative historically applied in clinical settings. Recently, 2-, 3-, and 4-...
Aureusidin protects against osteoarthritis via Caspase-3/gasdermin E-mediated pyroptosis [0.03%]
Aureusidin通过Caspase-3/气体衍生物E介导的焦亡保护骨关节炎
Shangxiang Feng,Kun Song,Hao Zhang et al.
Shangxiang Feng et al.
This study investigated the effects of Aureusidin on extracellular matrix (ECM) degradation and pyroptosis of chondrocytes in osteoarthritis. Network pharmacology, molecular docking, and pull-down assays were initially conducted to explore ...
Targeting NFS1-mediated ferroptosis mitigates alveolar injury in experimental idiopathic pulmonary fibrosis [0.03%]
靶向NFS1介导的铁死亡可减轻特发性肺纤维化小鼠的肺泡损伤
Jianzhong Li,Yi Cao,Yu Wang et al.
Jianzhong Li et al.
Idiopathic pulmonary fibrosis (IPF), a lethal form of interstitial lung disorder, has recently been recognized as a ferroptosis-associated disorder, with the inhibition of ferroptosis offering promising therapeutic potential. Cysteine desul...