Targeting sonic hedgehog (shh) signaling pathways by the concentration-dependent topical resveratrol for protection from cyclophosphamide-induced alopecia in a mouse model [0.03%]
浓度依赖型白藜芦醇局部用药通过靶向声波刺猬信号途径预防环磷酰胺致小鼠脱毛效力研究
Aml A El-Din,Dina M Tahoon,Maaly A Abd Elmaaboud et al.
Aml A El-Din et al.
Background: Chemotherapy-induced alopecia (CIA) is a common and inevitable side effect of systemic cancer treatment. There is an urgent need for novel therapies for cancer patients suffering from hair loss to improve thei...
Andrographolide-induced PANoptosis underlies its multiple organ toxicity in mice [0.03%]
andrographolide诱导的PANoptosis是其小鼠多器官毒性的原因
Na Lu,Yuan-Wen Cai,Qi-Hai Cai et al.
Na Lu et al.
Andrographolide (Andro), the major bioactive component of Andrographis paniculata, exhibits potent anti-inflammatory properties but has raised safety concerns due to reported organ toxicity. This study aimed to investigate the mechanisms un...
Exposure to a PFAS mixture alters cholesterol lipoprotein subfractions and induces a foam cell-like aortic macrophage expression profile in hyperlipidemic LDLr-/- mice [0.03%]
全氟和多氟烷基物质混合暴露改变高脂血症LDLr基因敲除小鼠胆固醇脂蛋白亚组分并诱导主动脉泡沫细胞样巨噬细胞表型生成
Katherine Roth,Zhao Yang,Manisha Agarwal et al.
Katherine Roth et al.
Per- and polyfluoroalkyl substances (PFAS) have been associated with elevated cholesterol, a clinically-relevant risk factor for atherosclerosis. Macrophages are key mediators of atherosclerosis progression through their polarization to var...
Corrigendum to "Arsenic exposure affects Pdgfrα stromal cells in the ileum of the small intestine" [Toxicology and Applied Pharmacology Volume 505, December 2025, 117582] [0.03%]
关于“砷暴露影响小肠回肠Pdgfrα基质细胞”一文的勘误(毒性学与应用药理学杂志,卷505,2025年12月,117582)
Scott W Ventrello,Kayla A Lea,Lisa J Bain
Scott W Ventrello
Published Erratum
Toxicology and applied pharmacology. 2025 Dec 6:117677. DOI:10.1016/j.taap.2025.117677 2025
Ghrelin-disrupting activity of arsenic and its relation to cardiometabolic diseases [0.03%]
砷干扰胃饥饿素的作用及其与心血管代谢性疾病的关系研究
Kamrun Nahar Rossi,Faysal Abedin,Nayan Chandra Mohanto et al.
Kamrun Nahar Rossi et al.
Arsenic (As) exposure is linked to a special type of obesity without increasing body mass index. This obesity is accompanied by the reduction of skeletal muscle mass and elevation of insulin resistance (IR). Obesity and IR are the key risk ...
Corrigendum to "Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza Bunge via network pharmacology: Unveiling their roles in the modulation of platelet activation and thrombus formation" [Toxicology and Applied Pharmacology volume 484, March 2024, 116871] [0.03%]
关于“网络药理学阐明丹参中活性化合物的独特调节作用和机制：揭示其在血小板活化和血栓形成调控中的作用”（发表于Toxicology and Applied Pharmacology杂志，卷484，2024年3月，116871）的勘误表
Ying Zhang,Guang Xin,Qilong Zhou et al.
Ying Zhang et al.
Published Erratum
Toxicology and applied pharmacology. 2025 Dec 4:117668. DOI:10.1016/j.taap.2025.117668 2025
Silico, in vitro, and in vivo studies of a 2-substituted quinazolin-4(3H)-one in T-cell acute lymphoblastic leukemia [0.03%]
T细胞急性淋巴细胞白血病2-取代喹唑啉-4(3H)-一元醇的硅氧烷，体外和体内研究
Giorgio Antoniolli,Gilberto Carlos Franchi Junior,Keli Lima et al.
Giorgio Antoniolli et al.
This study reports the synthesis, physicochemical characterization, and preliminary pharmacological evaluation of a novel 2-substituted quinazolin-4(3H)-one, Qona11. The compound was synthesized from 2-aminobenzamide and 1H-benzo[d]imidazol...
Maternal ozone exposure and differential cardiometabolic outcomes in aging male and female offspring [0.03%]
母体暴露于臭氧对衰老大鼠子代的心血管元代谢结局的影响及其性别差异性研究
Brendan Yoo,Janice A Dye,Mehdi S Hazari et al.
Brendan Yoo et al.
Fetal development is a vulnerable life stage for exposure to environmental stressors. Gestational exposure to ozone (O3) has been shown to compromise fetal growth, predisposing offspring to increased risk of pulmonary and metabolic dysfunct...
DEHP induces hepatic fibrosis through STAT3-SLC7A11-ROS axis [0.03%]
邻苯二甲酸二乙酯通过STAT3-SLC7A11-ROS轴诱导肝纤维化
Siqin Liang,Zhiliang Xu,Xiaoxiang You et al.
Siqin Liang et al.
Di-(2-ethylhexyl) phthalate (DEHP) is a pervasive environmental contaminant commonly found in daily life, and numerous studies have linked it to the progression of liver diseases and organ fibrosis. However, the precise molecular mechanisms...
Ditrioxzin synergizes with 2-deoxy-d-glucose to induce redox-dependent metabolic crisis in gastric cancer through dual targeting of peroxiredoxin 3 and glycolysis [0.03%]
二脱氧葡萄糖增敏ditriozin诱导抗氧化和代谢偶联危机用于胃癌治疗
Nan Su,Lulu Pan,Xiaojing Shi et al.
Nan Su et al.
Emerging evidence demonstrates that dual inhibition of glycolysis and mitochondrial function represents a potent anticancer strategy. Here, we report that Ditrioxzin (DTO), a synthetic ent-kaurane diterpenoid analog, selectively disrupts mi...