Shionone ameliorates pulmonary fibrosis by activating mitophagy via PINK1-Parkin pathway [0.03%]
石杉碱甲通过PINK1-Parkin途径激活线粒体自噬从而改善肺纤维化
Yijia Su,Qiang Fu,Xilin Wu et al.
Yijia Su et al.
Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited clinical treatment options. Shionone (SHI), a major active compound derived from Ligularia fischeri Turcz (LF), has shown pharmacological potential; h...
CYP genetic polymorphism, and CYP3A inducers and inhibitors regulate apatinib metabolism: Consequences for drug exposure and toxicity risks [0.03%]
CYP基因多态性以及CYP3A诱导剂和抑制剂调节阿帕替尼代谢：对药物暴露及毒性风险的影响
Zhe Wang,Le-Hao Jin,Ni-Hong Pang et al.
Zhe Wang et al.
Apatinib is a tyrosine kinase inhibitor metabolized by hepatic cytochromes P450 (CYPs). This study investigated how CYP genetic variations affect apatinib metabolism and response. We employed a multi-scale approach including enzyme kinetic ...
Celastrol delays the progression of hepatocellular carcinoma by suppressing SLC1A5-mediated glutamine dependence [0.03%]
雷公藤春碱通过抑制SLC1A5介导的谷氨酰胺依赖性延缓肝癌进展
Simeng Xiao,Yun Zhao,Zhiguo Chen et al.
Simeng Xiao et al.
Hepatocellular carcinoma (HCC) is a serious public health problem worldwide due to its high mortality rate and specific therapeutic strategies with rare effective drugs. Glutamine, a critical nutrient for sustaining the cellular vital activ...
Pioglitazone attenuates cardiovascular remodeling cadmium-induced through the MAPK pathway [0.03%]
蛋白酶体抑制剂卡非佐米通过促进自噬诱导多发性骨髓瘤细胞凋亡
Victor Enrique Sarmiento-Ortega,Diana Moroni-González,José Everardo Avelino-Cruz et al.
Victor Enrique Sarmiento-Ortega et al.
Cadmium (Cd) is an environmental pollutant increasingly linked to cardiovascular morbidity. While its toxic effects have been well documented at high doses, the impact of chronic exposure to the minimal risk level remains underexplored. Thi...
Corrigendum to "Toxicokinetics and in vivo genotoxicity after single dose oral gavage and intravenous administration of N-Nitrosonornicotine in Sprague Dawley rats" [Toxicology and Applied Pharmacology 505 (2025), 117572] [0.03%]
关于“N-亚硝基烟碱单剂量灌胃和静脉给药后的毒代动力学及体内致遗传毒性[(Sprague Dawley大鼠) ]的研究”的勘误[《 toxicology and applied pharmacology》第505期(2025), 117572]
Mamata De,Ashley Fields,Guy Lagaud
Mamata De
Published Erratum
Toxicology and applied pharmacology. 2025 Dec 12:117689. DOI:10.1016/j.taap.2025.117689 2025
Mechanistic insights into trimetazidine's protection against bladder ischemia-reperfusion injury via mirR-211/CHOP modulation and SIRT1/AMPK/PGC1α-mediated mitochondrial biogenesis [0.03%]
曲美他嗪通过调节mirR-211/CHOP和SIRT1/AMPK/PGC1α介导的线粒体生物发生保护膀胱缺血再灌注损伤的机制研究
Sultan Alrashdi,Shimaa K Mohamed,Mohamad Elbaz et al.
Sultan Alrashdi et al.
Bladder ischemia, frequently associated with vascular insufficiency, contributes to lower urinary tract symptoms via oxidative stress, inflammation, endoplasmic reticulum (ER) stress, mitochondrial defect, and apoptosis. Ischemia-reperfusio...
Rupestonic acid targets ENO1 to exert antitumor activity and synergizes with paclitaxel in hepatocellular carcinoma [0.03%]
RUPESTONIC酸靶向ENO1发挥抗肿瘤作用并可与紫杉醇联合用于肝细胞癌治疗
Shulipan Mulati,Maierdan Maimaitiming,Jianing Ma et al.
Shulipan Mulati et al.
Rupestonic acid, a sesquiterpene, has protective properties against liver damage, inflammation, and tumor formation. Despite these known effects, its specific role and mechanism of action in combating hepatocellular carcinoma (HCC) remain i...
Evaluation of 2-isopropyl-N-2,3-trimethylbutyramide by a comprehensive toxicity study using gpt delta rats [0.03%]
采用GPT DELTA大鼠对2-异丙基-2，3-三甲基丁酰胺进行综合毒性评价研究
Tatsuya Mitsumoto,Yuji Ishii,Norifumi Takimoto et al.
Tatsuya Mitsumoto et al.
2-Isopropyl-N-2,3-trimethylbutyramide (ITB) is a food-flavoring agent classified as an aliphatic amide. In 2016, the Joint FAO/WHO Expert Committee on Food Additives evaluated ITB and concluded that additional data on toxicity and in vivo g...
Gastrodin alleviates alcohol-induced developmental and neurotoxic effects in zebrafish larvae by suppressing ferroptosis via regulating the Nrf2/GPX4 signaling pathway [0.03%]
天麻素通过调节Nrf2 / GPX4信号通路抑制铁死亡从而缓解酒精对斑马鱼胚胎的发育毒性和神经毒性作用
Ruijing Li,Weili Yang,Lijuan Zheng et al.
Ruijing Li et al.
Prenatal alcohol exposure is a leading cause of developmental abnormalities and neurobehavioral deficits, collectively known as fetal alcohol spectrum disorder (FASD). The underlying molecular mechanisms, however, are not fully elucidated, ...
Duloxetine-induced inhibition of voltage-gated K+ 3.1 (Kv3.1) channels and underlying electrophysiological mechanisms [0.03%]
度洛西汀诱导的电压门控钾通道3.1(Kv3.1)抑制及其电生理机制研究
Jin Ryeol An,Junsu Jeong,Hye Ryung Kim et al.
Jin Ryeol An et al.
Duloxetine is a serotonin-norepinephrine reuptake inhibitor that has been widely used to treat major depression; however, it has also been associated with severe neuropsychiatric side effects, including hallucinations, confusion, and suicid...