Aloperine mitigates cigarette smoke-induced inflammation and pyroptosis by inhibiting the BRD4/NLRP3/GSDMD pathway in chronic obstructive pulmonary disease [0.03%]
Aloperine通过抑制BRD4/NLRP3/GSDMD信号通路缓解慢性阻塞性肺疾病中香烟烟雾引起的炎症和焦亡作用
Xiaofeng Li,Zhe Wang,Tingting Zhang et al.
Xiaofeng Li et al.
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and progressive airflow limitation, primarily caused by cigarette smoke (CS) exposure. Current pharmacological interventions for COPD merely slo...
Unveiling the therapeutic potential and leukemia risk of PD-166866 in sepsis via an integrated computational-experimental strategy [0.03%]
通过整合计算和实验策略揭示PD-166866在脓毒症中的治疗潜力和促白血病风险
Mingkai Chang,Ye Shang,Jianing Zheng et al.
Mingkai Chang et al.
Objective: This study evaluates the anti-sepsis efficacy and potential risks of the FGFR1 inhibitor PD-166866 by integrating network pharmacology, transcriptome sequencing, and network toxicology. ...
Benign cardiac troponin I release induced by elevated beat rate is associated with membrane bleb formation [0.03%]
心率加快引起的良性肌钙蛋白I释放与膜泡形成有关
Jomana Hatahet,Hannah J Nonarath,Mark T Zafiratos et al.
Jomana Hatahet et al.
Cardiac troponin I (cTnI), a key regulatory protein of cardiomyocyte contraction, serves as a clinical biomarker for cellular necrosis. Measuring circulating cTnI in preclinical studies is used to assess cardiotoxicity of new chemical entit...
Doxorubicin-induced cardiotoxicity under 28 GHz 5G-band electromagnetic radiation in rats: Insights into the mitigative role of vitamin C [0.03%]
维生素C对28GHz的5G电磁辐射环境下多柔比星引起的大鼠心脏毒性的影响研究
Atefeh Rahimi,Ali Rafati,S M J Mortazavi et al.
Atefeh Rahimi et al.
Doxorubicin (DOX), an effective anthracycline chemotherapeutic agent, induces cardiotoxicity through oxidative stress, mitochondrial dysfunction, and activation of apoptotic pathways. As millimeter-wave frequencies used in fifth-generation ...
Resveratrol mitigates TOCP-induced spinal cord neurotoxicity by suppressing ferroptosis, a process mediated through the p62/Keap1/Nrf2 pathway [0.03%]
白藜芦醇通过抑制自噬小体介导的p62/Keap1/Nrf2途径依赖性铁死亡来缓解三氧化二锡诱导的脊髓神经毒性
Sangping Li,Shule Tan,Xiangsheng Tian et al.
Sangping Li et al.
This study investigated the protective effects of resveratrol (Res) against tri-o-cresyl phosphate (TOCP)-induced spinal cord neurotoxicity in adult hens, focusing on its modulation of ferroptosis via the p62/Keap1/Nrf2 pathway. Resveratrol...
Repurposing of bithionol as a potential anxiolytic agent through NF-κB suppression: Insights from behavioural, biochemical, and molecular modelling studies [0.03%]
一种用于抗焦虑的再利用药物憋硫酚通过NF-κB抑制作用：来自行为学，生化和分子建模研究的观点
Kiran Satao,Maheshkumar Borkar,Angel Godad et al.
Kiran Satao et al.
Chronic stress activates neuroinflammatory responses through the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, rendering anxiety disorders the leading psychological disease. For the current inves...
Inhaled polystyrene nanoparticles may cause fibrotic lesions via immune dysregulation and energy metabolism disturbance [0.03%]
吸入式聚苯乙烯纳米颗粒可通过免疫失调和能量代谢紊乱导致纤维化病变
Wonkyun Jung,Man S Kim,Beom-Geon Kim et al.
Wonkyun Jung et al.
Microplastics have emerged as a major risk to human health. In this study, we dosed polystyrene nanoparticles (PS-NPs) via the pharynx for 90 days and assessed local and systemic toxicity. PS-NPs increased white blood cell counts and decrea...
Dapagliflozin regulates kynurenine metabolism and microglial activation to alleviate diabetes-associated cognitive impairment [0.03%]
达格列净通过调节犬尿酸代谢和小胶质细胞活化来缓解糖尿病相关的认知障碍
Yanhong Jia,Jiangxia Pang,Chen Sun et al.
Yanhong Jia et al.
Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has shown significant therapeutic potential in alleviating Diabetes-associated cognitive dysfunction (DACD). However, its specific effects on microglia remain to be further ...
Saxagliptin mitigates doxorubicin-induced cardiotoxicity by modulating NLRP3/caspase-1/IL-1β and TLR-4/NF-κB pathways [0.03%]
saxagliptin通过调节NLRP3/caspase-1/IL-1β和TLR-4/NF-κB途径缓解多柔比星引起的心脏毒性
Maha M Abdel-Fattah,Yasmeen M Abozaid,Basim Anwar Shehata Messiha et al.
Maha M Abdel-Fattah et al.
Doxorubicin (DOX) is a powerful anthracycline utilized in the management of several malignant disorders, involving both solid and hematological tumors. Despite its effectiveness as cytotoxic agent, its therapeutic use is restricted as cardi...
Establishment of a real-time monitored animal model to evaluate novel therapeutic strategies for organophosphorus nerve agent poisonings [0.03%]
建立一个实时监控的动物模型以评估新型治疗策略对有机磷神经剂中毒的疗效
Sofia Jonasson,Åsa Gustafsson,Johanna Qvarnström et al.
Sofia Jonasson et al.
Preclinical evaluation of oximes as antidotes for organophosphorus nerve agent (OPNAs) poisoning is predominantly based on protection ratio of the antidote against lethal doses. Developing protection indexes involves considerable animal dis...