GSDMD inhibitor GI-Y1 alleviates doxorubicin-induced cardiotoxicity via the inhibition of mitochondrial dysfunction [0.03%]
线粒体功能障碍介导的GSDMD抑制剂GI-Y1缓解多柔比星致心脏毒性
Yucong Zhang,Ruihan Zheng,Minne Xie et al.
Yucong Zhang et al.
Objective: This study aimed to explore GI-Y1's (a GSDMD inhibitor) protective effect against doxorubicin (Dox)-induced cardiotoxicity (DIC) and clarify its molecular mechanisms. ...
Norcantharidin inhibits the EZH2-mediated JAK2/STAT3 signaling pathway to inhibit the proliferation of non-small cell lung cancer [0.03%]
氨甲蝶呤通过抑制EZH2介导的JAK2 / STAT3信号通路抑制非小细胞肺癌增殖
Shuang Wu,Wei Zhang
Shuang Wu
Objective: The purpose of this study was firstly to investigate the anti-tumor effects of NCTD on NSCLC cell proliferation, apoptosis, migration, and invasion. Secondly, it aimed to explore whether these effects were asso...
Synergistic assault of DEHP and MPs: Unmasking the ER stress-triggered autophagic injury male fertility [0.03%]
DEHP和MPs的协同攻击：揭开内质网应激触发的自噬损伤导致的男性不育
Jiajun Guo,Xiaoyan Feng,Yuankun Zhou et al.
Jiajun Guo et al.
As an emerging category of environmental pollutants, microplastics (MPs) garner significant attention due to their exceptionally high exposure risk. Di(2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer in the plastics industry, share...
Akkermansia muciniphila enhances the antitumour efficacy of αPD-1 therapy in gastric cancer by remodelling the tumour immune microenvironment [0.03%]
Akkermansia muciniphila通过重塑肿瘤免疫微环境增强αPD-1治疗的抗肿瘤疗效
Ziyi Yang,Lanfan Liang,Xin Li et al.
Ziyi Yang et al.
There is growing advocacy for employing probiotics as adjuncts to potentiate immune checkpoint blockade (ICB) in cancer therapy. In this study, we investigated whether the probiotic Akkermansia muciniphila (A. muciniphila) could enhance the...
Sinapic acid attenuates colistin-driven nephrotoxicity by targeting the miRNA-21/SIRT1/NF-κB pathway and facilitating tubular repair and inflammation in a rat model [0.03%]
对甲基辛诺酸通过靶向miRNA-21/SIRT1/NF-κB通路并促进大鼠模型肾小管修复和炎症来缓解多粘菌素的肾毒性
Medine Akkan Öz,Hasan Şimşek,Selçuk Özdemir et al.
Medine Akkan Öz et al.
The present study aimed to investigate the nephrotoxic effects of colistin (CS) in a rat model and to elucidate the potential renoprotective mechanisms of sinapic acid (SA) at biochemical, molecular, and metabolic levels. Colistin administr...
Nicotinamide N-oxide alleviates sepsis-induced hepatic inflammation, oxidative stress, and mitochondrial damage depends on SIRT3/AKT signaling pathway [0.03%]
烟酰胺N氧化物通过SIRT3/AKT信号途径缓解内毒素性肝损伤中的炎症反应及线粒体功能障碍
Shujuan Liu,Pan Shi,Yichen Jin et al.
Shujuan Liu et al.
Sepsis frequently gives rise to acute hepatic injury, representing a prevalent and critical pathological manifestation associated with high morbidity and mortality, yet effective therapeutic strategies remain limited. In this study, sepsis-...
Effects of prenatal DINP exposure induced hepatic steatosis and underlying mechanism [0.03%]
孕期DINP暴露诱导肝脏脂变及其机制研究
Yahui Jin,Junli Zhao,Xinjing Wang et al.
Yahui Jin et al.
Prenatal exposure to diisononyl phthalate (DINP) exerts sex-specific effects on offspring liver lipid metabolism, yet the underlying mechanisms remain insufficiently defined. In this study, pregnant mice were administered DINP throughout ge...
Pre-treatment with sevoflurane alleviates hypoxia-reoxygenation-induced cardiomyocyte damage through PAX8-AS1-targeted miR-145-5p [0.03%]
异氟醚预处理通过PAX8-AS1/miR-145-5p通路缓解缺氧复氧诱导的心肌细胞损伤
Yan Xu,Xianglong Di,Ye Cai et al.
Yan Xu et al.
Objective: To explore the regulatory role of the lncRNA PAX8-AS1/miR-145-5p axis in the mitigation of hypoxia-induced damage to oxygenated (HR) myocardial cells by sevoflurane (Sev). ...
Salidroside derivative SHPL-49 accelerates cutaneous wound healing in diabetic mice by modulating macrophage-mediated TGF-β1/Smad2/3 signaling pathway [0.03%]
_salidroside衍生物SHPL-49通过调节巨噬细胞介导的TGF-β1 / Smad2 / 3信号通路加速糖尿病小鼠皮肤伤口愈合
Feiyun Wang,Zhouyun Ma,Anam Latif et al.
Feiyun Wang et al.
Impaired wound healing represents a major complication of diabetes, yet effective therapeutic options remain limited. Our research group has developed a salidroside derivative, SHPL-49, which exhibits antioxidant, anti-inflammatory, and pro...
Histone deacetylase SIRT2 regulates the development and metastasis of tongue cancer via FZD1-mediated Wnt/β-catenin pathway [0.03%]
组蛋白脱乙酰酶SIRT2通过FZD1介导的Wnt/β-catenin信号通路调控舌癌的发生发展及转移
Zizheng Lu,Minxiao Lin
Zizheng Lu
In this research, we mainly focus on the mechanism of histone deacetylase sirtuin 2 (SIRT2) affecting the growth and metastasis of tongue cancer using in vitro and in vivo experiments. Human tongue cancer cells SCC-25, SCC-9, CAL-27, CAL-33...