Cyclomulberrin represses renal cell carcinoma progression via ferroptosis activation [0.03%]
cyclomulberrin通过激活铁死亡抑制肾细胞癌进展
Xinyu Yi,Zhixuan Xie,Taian Jin et al.
Xinyu Yi et al.
Renal cell carcinoma (RCC) is one of the most common malignancies in the genitourinary system. Cyclomulberrin (CyM), a natural prenylated flavonoid, has shown anti-tumor potential. However, the efficacy and potential mechanisms of this trea...
Potassium channel tetramerization domain-containing 10 exerts a tumor suppressive function in breast cancer by destabilizing SLC7A11 to induce ferroptosis [0.03%]
钾通道四聚体结构域蛋白10通过使SLC7A11不稳定从而诱导铁死亡而在乳腺癌中发挥抑癌作用
Xin He,Ying Wang,Dan Wang et al.
Xin He et al.
Potassium channel tetramerization domain-containing 10 (KCTD10) plays a crucial role in the progression of various tumors. However, comprehensive studies on the involvement of KCTD10 in breast cancer are still lacking. This research aims to...
Sustained cadmium exposure and hyperglycemia additively drives mitochondrial dysfunction in hepatic cells: Implications for MASLD etiopathogenesis [0.03%]
持续的镉暴露和高血糖会协同驱动肝细胞线粒体功能障碍：对MASLD发病机制的意义
Rahul Kumar,Ashwin Chinala,Sharina Desai et al.
Rahul Kumar et al.
Effects of chronic heavy metal stress on hepatocellular pathophysiology remains ill-understood. Human livers are a long-term accumulative site for many toxic heavy metals (e.g., cadmium and arsenic) whose health effects are unknown. In the ...
EP300 promotes cervical cancer progression through a Wnt/β-catenin-dependent HIF-1α signaling axis [0.03%]
EP300通过Wnt/β-catenin依赖的HIF-1α信号轴促进宫颈癌进展
Yue Zhang,Yongxin Zhang,Ke Wang
Yue Zhang
This study aimed to investigate the role of EP300 in cervical cancer progression, focusing on its functional effects related to pyroptosis under Wnt/β-catenin-dependent conditions. In SiHa and HeLa cells, EP300 was silenced using lentivira...
Corrigendum to "Pinocembrin protects against cisplatin-induced liver injury via modulation of oxidative stress, TAK-1 inflammation, and apoptosis" [Toxicology and Applied Pharmacology, Volume 502, September 2025, 117433] [0.03%]
“紫杉醇诱导的肝损伤通过调节氧化应激、TAK-1炎症和凋亡”[毒理学与应用药理学，第502卷，2025年9月，117433]的勘误表
Samar F Darwish,Sherif S Abdel Mageed,Abdulla M A Mahmoud et al.
Samar F Darwish et al.
Published Erratum
Toxicology and applied pharmacology. 2026 Jan 18:117719. DOI:10.1016/j.taap.2026.117719 2026
Nuclear protein 1 defends against acute pancreatitis by mitigating pancreatic acinar cell ferroptosis through the maintenance of cellular iron homeostasis [0.03%]
核蛋白1通过维持细胞铁稳态来防御急性胰腺炎中的胰腺细胞铁死亡的作用机制研究
Xiangtian Zeng,Wenhui Chen,Qixin Dai et al.
Xiangtian Zeng et al.
Acute pancreatitis (AP) is a severe inflammatory condition marked by pancreatic acinar cell death, with ferroptosis emerging as a critical factor in its pathogenesis. The nuclear protein 1 (Nupr1) has been identified as a key regulator of f...
Genipin ameliorates cholestatic liver injury in Mdr2-/- mice: the role of gut microbiota modulation by its dialdehyde intermediates [0.03%]
盾肝素小鼠胆汁淤积性肝损伤的五味子丙素改善作用及肠道菌群调控机制研究
Junli Jin,Lulu Zhu,Chengjiang He et al.
Junli Jin et al.
Cholestasis causes severe hepatobiliary diseases with poor prognosis and limited therapeutic drugs. Under cholestatic conditions, impairment of the bile acid (BA)-metabolizing function of gut microbiota, along with abnormal BA profiles, exa...
Pharmacological inhibition of USP7 attenuates deltamethrin-induced neuronal ferroptosis via GPX4 stabilization [0.03%]
药理学抑制USP7通过GPX4稳定缓解高效氯氟氰菊酯诱导的神经元铁死亡
Minjia Wu,Yang Chen,Peixuan Ma et al.
Minjia Wu et al.
Recent studies suggest a significant association between deltamethrin (DM) exposure and an elevated risk of neurodegenerative diseases, yet the underlying molecular mechanisms remain poorly understood. The role of Ubiquitin-specific proteas...
Min Hee Yang,Ducdat Le,Thinhulinh Dang et al.
Min Hee Yang et al.
Metastasis driven by epithelial-mesenchymal transition (EMT) remains a critical challenge in colorectal cancer treatment. This study investigated GKB7I-53, a saponin compound isolated through feature-based molecular networking, as a potenti...
Paclitaxel impairs mitochondrial dynamics in human sensory-like neuron cells [0.03%]
紫杉醇影响人类感觉神经元样细胞的线粒体动力学
Mariana Caprio Schiess,Gessica Sabrina de Assis Silva,Natália Gabriele Hösch et al.
Mariana Caprio Schiess et al.
Taxanes are considered first-line chemotherapeutic agents to treat solid cancer. Paclitaxel (PTX) is a commonly used taxane and although effective, it induces peripheral chronic neuropathy in around 60-70% of patients. Studies have demonstr...