Targeting aryl hydrocarbon receptor signaling attenuates hypertension programmed by maternal Di-2-ethylhexylphthalate exposure [0.03%]
靶向aryl hydrocarbon受体信号传导可减轻母体Di-2-乙基己基邻苯二甲酸酯暴露所导致的高血压编程作用
Chien-Ning Hsu,Hsi-Yun Liu,Chih-Yao Hou et al.
Chien-Ning Hsu et al.
Adverse early-life conditions can predispose offspring to long-term health risks. Phthalate exposure, particularly to di-2-ethylhexylphthalate (DEHP), during pregnancy and lactation has been implicated in programming offspring hypertension ...
Human umbilical cord mesenchymal stem cells-derived exosomes restore lung architecture and reduce the susceptibility to asthma of offspring in maternal asthma [0.03%]
母亲哮喘大鼠宫内环境所致子代肺结构重塑及功能异常的表观遗传学机制研究及其脐带间充质干细胞来源外泌体的干预作用
Xin Li,Yueting Wu,Min Mao et al.
Xin Li et al.
Asthma is a heterogeneous disorder driven by inflammatory processes that promote pathogenic airway remodeling. Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Exos) emerge as a compelling therapeutic candidate to disrupt...
Thiophene-based styrene derivative improves colitis symptoms in DSS-induced BALB/C mice through AhR-mediated gut barrier function and inflammatory responses [0.03%]
噻吩基苯乙烯衍生物通过芳香烃受体介导的肠道屏障功能和炎症反应改善DSS诱导的BALB/c小鼠结肠炎症状
Ang-Kun Yang,Yong-Liang Li,Yan-Ying Chen et al.
Ang-Kun Yang et al.
Worldwide incidence and prevalence of ulcerative colitis (UC) has been rising in recent years, which can occur at any age, with a high frequency seen in young children and people aged 40 to 50. The aryl hydrocarbon receptor (AhR) activation...
Long-term exposure to di-(2-ethylhexyl) phthalate induced uterine histopathologic alterations in female mice [0.03%]
长期暴露于邻苯二甲酸二乙基己酯可引起小鼠子宫组织病理学改变
Je Yeon Lee,Jin Su Kim,Javeria Zaheer et al.
Je Yeon Lee et al.
Objective: To investigate the effects of long-term Di-(2-ethylhexyl) phthalate (DEHP) exposure on the female reproductive system, employing different dosages and durations of exposure. ...
Angelicin attenuates sepsis-associated splenic injury by targeting NF-κB/JAK2/STAT3 and PI3K/Akt pathways to inhibit inflammation and apoptosis [0.03%]
天使素通过靶向NF-κB / JAK2 / STAT3和PI3K / Akt途径抑制炎症和凋亡来缓解脓毒症相关的脾损伤
Enzhuang Pan,Huilin Sun,Zhihao Ma et al.
Enzhuang Pan et al.
Sepsis represents a clinical syndrome characterized by maladaptive host immune dysregulation in response to infection, leading to potentially fatal multiorgan dysfunction. As the largest secondary lymphoid organ in mammals, spleen tissue pl...
Transcription factor TFAP2A drives EMT progress by activating BDKRB1 transcription: The potential mechanism by which TFAP2A promotes idiopathic pulmonary fibrosis [0.03%]
转录因子TFAP2A通过激活BDKRB1转录驱动上皮间质转化：TFAP2A促进特发性肺纤维化的潜在机制研究
Jingwen Zhang,Xin Jin,Yajiao Sun et al.
Jingwen Zhang et al.
Epithelial-mesenchymal transition (EMT)-inducing signals trigger the accumulation of extracellular matrix, thereby contributing to organ pathology, including idiopathic pulmonary fibrosis (IPF). Transcription factor AP-2 alpha (TFAP2A) has ...
Expression of drug transporters in human allogenic transplanted kidneys in acute rejection [0.03%]
急性排异反应中人同种异体移植肾的药物转运蛋白表达
J Łapczuk-Romańska,J Hybiak,K Piotrowska et al.
J Łapczuk-Romańska et al.
Kidney drug transporters, primarily located in the basolateral and apical membranes of proximal tubule cells, play a key role in the secretion and reabsorption of drugs and endogenous compounds. Recent studies have demonstrated that kidney ...
Cardamonin attenuates osteoporosis progression and promotes osteogenic differentiation of bone mesenchymal stem cells by upregulating TCF4 expression [0.03%]
姜黄素诱导的TCF4上调对骨髓间充质干细胞成骨分化的促进作用及对骨质疏松症发展的抑制作用研究
Haizhong Sun,Runwu Hu,Jianlong Wu
Haizhong Sun
Background: Osteoporosis is a common skeletal metabolic disorder. Cardamonin (CAR) is a natural chalcone compound with multiple activities. However, the role and mechanism of CAR in osteoporosis progression remain largely...
Identification of key targets and mechanisms of isoorientin in osteoporosis treatment through integrated network pharmacology and experimental validation [0.03%]
整合式网络药理学与实验验证鉴定异 orientin 治疗骨质疏松症的关键靶点和机制
Jinku Guo,Jun Xie,Ankai Xu et al.
Jinku Guo et al.
Osteoporosis is a prevalent metabolic bone disorder characterized by diminished bone mineral density and elevated fracture susceptibility. Although isoorientin (ISO) has emerged as a promising candidate for osteoporosis treatment, its molec...
Nab-paclitaxel inhibits angiogenesis via the CYR61/integrin αvβ3 Axis: Exosomal proteomics insights into breast cancer chemoprevention [0.03%]
纳米白蛋白结合紫杉醇通过CYR61/整合素αvβ3轴抑制血管生成：乳腺癌化学预防的外泌体蛋白质组学见解
Yi Zhang,Jiajun Wang,Zhongjie Deng et al.
Yi Zhang et al.
Albumin-bound paclitaxel (Nab-PTX), a nanoparticle albumin-bound formulation in which paclitaxel is conjugated to human serum albumin, has emerged as a pivotal agent in cancer therapy. Its significance stems not only from direct cytotoxic e...