Tussilagone inhibits MRGPRX2-mediated mast cell degranulation and suppresses pseudo-allergic reactions [0.03%]
塔西拉贡抑制MRGPRX2介导的肥大细胞脱颗粒并抑制伪过敏反应
Ping-Ping Yan,Ting-Ting Huang,Mawusse K I Attiogbe et al.
Ping-Ping Yan et al.
Mas-related G protein-coupled receptor X2 (MRGPRX2) is a crucial target in pseudo-allergic reactions. Tussilagone (Tus), the main bioactive component derived from Tussilago farfara, has anti-inflammatory effects, but its potential inhibitor...
Icariin regulates osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis, potentially via the AMPK-mTOR-autophagy pathway [0.03%]
淫羊藿苷通过AMPK-mTOR-自噬信号通路调节绝经后骨髓间充质干细胞成脂分化作用研究
Yuqing Zeng,Haitao Wang,Jingtao Hu et al.
Yuqing Zeng et al.
Background: Postmenopausal osteoporosis (PMOP) is a bone disease resulting from estrogen deficiency. This investigation explores the impact of icariin (Ica) on PMOP. ...
Network toxicology, molecular docking, and multi-level bioinformatics integration reveal the targets and mechanisms linking benzo[a]pyrene exposure to ischemic stroke [0.03%]
网络毒理学、分子对接及多层生物信息学整合揭示苯并[a]芘暴露致缺血性卒中的靶点及机制
Jun Wu,Kuan Jiang,Ming Qi et al.
Jun Wu et al.
This study aims to clarify the potential mechanisms of ischemic stroke (IS) induced by benzo[a]pyrene (BaP) through integrated network toxicology, molecular docking, and multi-level bioinformatics analyses. Targets of Bap were obtained from...
Ethyl gallate attenuates 5-flurouracil induced hepatic injury via MAPK/NF-κB downregulation in rats [0.03%]
棓酸乙酯通过调节MAPK/NF-κB信号通路减轻5-氟尿嘧啶所致肝损伤
Maruthamuthu Thetchana Priya,Somasundaram Sanjay,Muthusethupathi Sharmila et al.
Maruthamuthu Thetchana Priya et al.
Background and aim: 5-Fluorouracil (5-FU) is known to cause liver injury in cancer patients. Experimental studies have reported that 5-FU induces oxidative stress and inflammation. Ethyl gallate (EG), a plant-derived phyt...
Neuroprotective potential of orphenadrine in focal cerebral ischemia: A neurobehavioral and mechanistic approach [0.03%]
奥芬拉明在局灶性脑缺血中的神经保护潜力：一种神经行为和机制的方法
Pinki Balhara,Sakeel Ahmed,Neeru Vasudeva et al.
Pinki Balhara et al.
Ischemic stroke is a leading cause of mortality and disability globally, with limited therapeutic options. This study hypothesized that orphenadrine, an NMDA antagonist with neuroprotective, anti-inflammatory and analgesic properties would ...
Protective effect of Florfenicol against DSS-induced ulcerative colitis by inhibiting cellular senescence and reducing inflammation via the AMPK signaling pathway [0.03%]
氟苯尼考通过AMPK信号通路抑制细胞衰老和减少炎症来预防DSS诱导的溃疡性结肠炎的作用研究
Wei Lian,Qinran Hou,Jinchan Liu et al.
Wei Lian et al.
Ulcerative colitis (UC) is a chronic inflammatory disorder of unclear etiology. Senescence-related signs have been detected in the intestinal tissue of UC patients. Senescence is known to amplify the body's inflammatory response, potentiall...
Intranasal exposure of poly (I:C) exacerbates OVA-induced allergic asthma by causing a major shift in the immune response [0.03%]
聚(I:C)的鼻内暴露通过引起免疫反应的主要转变来加重卵清蛋白诱导的过敏性哮喘
Ayushi Sandhu,Amarjit S Naura
Ayushi Sandhu
Viral respiratory infections are the major cause of exacerbation of allergic asthma, often resulting in increased emergency visits and hospitalizations. However, the understanding of the immune pathways at the cellular/molecular level under...
The effects of tungsten inhalation and continuous administration of angiotensin II on cardiac injury and pulmonary outcomes [0.03%]
钨吸入和持续给予血管紧张素II对心脏损伤和肺部结局的影响
Milad MazloumiBakhshayesh,Russell P Hunter,Brenna Baird et al.
Milad MazloumiBakhshayesh et al.
Tungsten exposure is associated with multiple cardiovascular diseases, but limited information exists on the mechanistic underpinnings of these relationships. The current study investigated the individual and combined effects of angiotensin...
Iatrogenic plasticizer Di(2-ethylhexyl) phthalate (DEHP) exposure increases Sepsis mortality risk: Machine learning implicates monocyte-driven immune dysregulation [0.03%]
医源性塑化剂邻苯二甲酸二丁酯(DEHP)增加脓毒症的死亡风险：机器学习表明单核细胞介导的免疫失调的作用
Jun-Jie Gao,Li-Zhu Huang,Tao Wang et al.
Jun-Jie Gao et al.
Sepsis poses a significant global health burden, and ICU patients are disproportionately exposed to di(2-ethylhexyl) phthalate (DEHP), an immunotoxic plasticizer that leaches from PVC medical devices; however, whether this exposure causally...
Multi-omics reveal the key role of gut microbiota metabolism in adenine-induced chronic kidney disease [0.03%]
多组学揭示肠道菌群代谢在腺嘌呤诱导的慢性肾脏疾病中的关键作用
Yijing Xin,Hui Ma,Xiang Li et al.
Yijing Xin et al.
The gut microbiota plays a crucial role in the progression of chronic kidney disease (CKD). The adenine-induced CKD mouse model is widely employed in preclinical research, yet the effects of adenine on the composition and metabolic function...