Aloperine alleviates lung ischemia-reperfusion injury by modulating ferroptosis via the STAT-1 pathway [0.03%]
阿洛波宁通过调节STAT-1通路铁死亡从而缓解肺缺血再灌注损伤
Junshen Xiao,Shichao Wei,Dou Huang et al.
Junshen Xiao et al.
Lung ischemia-reperfusion injury (LIRI) is a severe complication of lung transplantation and acute respiratory distress syndrome, leading to significant pulmonary dysfunction. Aloperine, a natural alkaloid derived from Sophora alopecuroides...
RUNDC3A-AS1 is an adverse prognostic factor for triple-negative breast cancer which mediates the Warburg effect and Adriamycin resistance by targeting miR-224-3p/COL5A2 [0.03%]
RUNDC3A-AS1通过靶向miR-224-3p/COL5A2介导三阴性乳腺癌的瓦博格效应和阿霉素抗性成为三阴性乳腺癌不良预后因素
Linna Kong,Xiaoyan Liu,Huihui Zhang et al.
Linna Kong et al.
Breast cancer has become the most common malignant tumor among women worldwide, among which triple-negative breast cancer (TNBC) is a subtype with the worst prognosis. Although the function of long non-coding RNA (lncRNA) RUNDC3A-AS1 in oth...
PM2.5-induced ferroptosis via the miR-188-3p/GPX4 axis disrupts renal erythropoietin production [0.03%]
miR-188-3p/GPX4信号轴介导的铁死亡打乱肾源性促红细胞生成素产生及机制研究
Wenqi Chen,Shanshan Chen,Lirong Bai et al.
Wenqi Chen et al.
Exposure to fine particulate matter (PM2.5) is a significant environmental risk factor for renal pathologies, including chronic kidney disease and acute kidney injury. Ferroptosis is increasingly implicated in kidney pathology or PM2.5-indu...
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway [0.03%]
肉桂醛通过PTP1B/PI3K/AKT/mTOR信号通路调节糖酵解抑制胃癌的发展进展
Xuejing Qiao,Da Xue,Zhijun Hu et al.
Xuejing Qiao et al.
Gastric cancer (GC) is a prevalent malignancy for which novel therapeutic approaches are urgently needed. Cinnamaldehyde (CA), a natural compound with anti-tumor potential, has an unclear mechanism of action in GC. This study aimed to inves...
Alleviation of cigarette smoke-induced cellular senescence in BALB/c mice by the Lipoxin A4 receptor agonist BML-111 is associated with mitophagy [0.03%]
利oxide A4受体激动剂BML-111通过诱导线粒体自噬缓解BALB/c小鼠吸烟引起的细胞衰老
Xin Li,Hui Xu,Meng Shi et al.
Xin Li et al.
Cigarette smoke (CS) significantly accelerates age-associated pulmonary pathologies by promoting cellular senescence. BML-111, a synthetic lipoxin A4 analog, exhibits therapeutic potential in inflammatory diseases owing to its antioxidant a...
Dexmedetomidine regulates fatty acid oxidation through the AMPK/PGC-1α/CPT1A pathway to mitigate renal ischaemia-reperfusion injury [0.03%]
右美托咪啶通过AMPK/PGC-1α/CPT1A信号通路调节脂肪酸氧化以减轻肾缺血再灌注损伤
Cong-Li Zhang,Yan Yan,Ke Wang et al.
Cong-Li Zhang et al.
Objective: This study aimed to investigate whether dexmedetomidine (Dex) attenuates renal ischaemia-reperfusion injury (RIRI) by regulating fatty acid oxidation and to explore its underlying mechanisms. ...
Alterations in the jejunal 5-hydroxytryptamine synthesis and turnover in septic mice induced by cecal ligation and puncture [0.03%]
结扎穿孔法制备脓毒症小鼠回肠5-羟色胺合成和更新的变化
Ayata Kuroda,Takuji Machida,Sachiko Hiraide et al.
Ayata Kuroda et al.
Recent studies have shown that endogenous 5-hydroxytryptamine (5-HT) facilitates in the progression of sepsis pathology. We aimed to characterize the impact of sepsis induced by cecal ligation and puncture (CLP) surgery on 5-HT synthesis an...
Isopropylated phenyl phosphate, an organophosphorus flame retardant, induces depressive- and anxiety-like behaviors in mice [0.03%]
异丙基苯基磷酸盐诱导小鼠抑郁和焦虑行为
Yuina Inoue,Shun Chiba,Hayato Maeda et al.
Yuina Inoue et al.
Isopropylated phenyl phosphate (IPP), commonly used as a flame retardant in a number of consumer products and construction materials, has been detected in human biological samples, raising concerns about human health. Limited information is...
Schisandrol A induces cardiac developmental toxicity in zebrafish (Danio rerio) via disruption of calcium homeostasis, oxidative stress, and apoptosis [0.03%]
五味子醇A通过干扰钙稳态、氧化应激和凋亡诱导斑马鱼心脏发育毒性
Wensi Liu,Yaoyao Chu,Qilin Li et al.
Wensi Liu et al.
Schisandrol A (SA) is a major lignan component of Schisandra chinensis with anti-inflammatory and antioxidant activities, yet its developmental and cardiac safety profile remains unclear. In this study, a zebrafish (Danio rerio) embryo mode...
Interference with IL-13/JAK1/STAT6 inflammatory signaling by dipalmitoyl phosphoethanolamine-polyethylene glycol (DPPE-PEG); A CD1d-dependent antagonist to iNKT cells; contributes to retarding the advancement of oxazolone colitis [0.03%]
二棕榈酰基磷酰乙醇胺-聚乙二醇（DPPE-PEG）干扰IL-13/JAK1/STAT6炎症信号；一种CD1d依赖性的iNKT细胞拮抗剂；可延缓异恶唑酮结肠炎的进展
Esraa Abdel-Nassir Abdel-Razek,Heba M Mahmoud,Amany A Azouz
Esraa Abdel-Nassir Abdel-Razek
Ulcerative colitis-associated immune dysregulation necessitates an appropriate and effective therapy to suppress its progression and achieve sustained remission. The current research was designed to examine the prospective anti-colitis mech...