Integrative network toxicology and experimental validation reveal novel molecular mediators of omeprazole-induced nephrotoxicity [0.03%]
整合网络毒理学和实验验证揭示了奥美拉唑诱导肾毒性的新型分子介导因素
Qian Huang,Yuqian Li,Zhiliang Gao et al.
Qian Huang et al.
Omeprazole, a widely used proton pump inhibitor, has been increasingly linked to adverse renal outcomes such as acute kidney injury (AKI) and chronic kidney disease (CKD), yet its nephrotoxic mechanisms remain unclear. In this study, we uti...
Endometriosis lesion growth inhibition and immune modulation function of thymol in vitro and in vivo [0.03%]
肉桂醛和百里酚对内异症的体内外免疫调节及抑瘤机制研究
Hyewon Jang,Wonhyoung Park,Hee Seung Kim et al.
Hyewon Jang et al.
Thymol, a phenolic monoterpene derivative found in the essential oil of Thymus vulgaris L., Lamiaceae, is currently under investigation for potential applications in pharmaceuticals, functional foods, and cosmetics. Despite ongoing research...
mTOR mediates airway epithelial E-cadherin disruption in toluene diisocyanate-induced asthma [0.03%]
mTOR介导的甲苯二异氰酸酯诱导的哮喘气道上皮E-钙黏蛋白损伤
Lin Fu,Lichang Chen,Xianru Peng et al.
Lin Fu et al.
E-cadherin is a critical adheren junctional protein for maintaining airway epithelial integrity. Downregulation of E-cadherin is commonly seen in asthma. Mammalian target of rapamycin (mTOR), a central regulator of metabolism, is implicated...
Paeoniflorin attenuates ASA-induced enteropathy in simulated high-altitude hypoxia in rats by regulating intestinal inflammation, intestinal barrier, and intestinal flora [0.03%]
芍药苷通过调节肠黏膜炎症、屏障功能及肠道菌群平衡减轻高原低氧环境下阿司匹林引起的肠病损伤
Ailifeire Tuerxuntayi,Wenhui Shi,Tian Shi et al.
Ailifeire Tuerxuntayi et al.
Purpose: This study aimed to investigate whether high-altitude hypoxia exacerbates non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury and to evaluate the protective effects of Paeoniflorin (PF). ...
Aucubin directly targets β-catenin to co-suppress Wnt and HIF-1 pathways in ovarian cancer: Computational and experimental validation [0.03%]
aucubin直接针对β-连环蛋白以协同抑制卵巢癌中的Wnt和HIF-1通路：计算与实验验证
Zhijian Pan,Han Wu,Yancai Liu et al.
Zhijian Pan et al.
Ovarian cancer (OV) is a highly lethal malignancy plagued by chemoresistance, necessitating the development of novel therapeutic agents. The Wnt/β-catenin pathway, driven by its central component β-catenin (CTNNB1), is a key oncogenic axi...
Letter to the editor related to: Huang et al. Effect of parental perinatal exposure to L-glutamate monosodium salt monohydrate on developmental neurotoxicity in rat offspring [0.03%]
关于黄等人文章的来信：父母围产期接触L-谷氨酸单钠盐一水合物对大鼠后代发育神经毒性的影响
Ivonne M C M Rietjens
Ivonne M C M Rietjens
This is a letter to the Editor related to: Huang et al. Effect of parental perinatal exposure to L-Glutamate Monosodium Salt Monohydrate on developmental neurotoxicity in rat offspring published in 2025 in Toxicol. Appl. Pharmacol., 502; 11...
Schisantherin A alleviates hepatotoxicity induced by diosbulbin B in mice via suppressing metabolic activation of diosbulbin B [0.03%]
石菖蒲素A通过抑制贝母碱B的代谢活化缓解贝母碱B致小鼠肝毒性
Shuo Wang,Bufan Yang,Guangyao Li et al.
Shuo Wang et al.
Diosbulbin B (DLB) is the most abundant diterpene lactone in herbal medicine Dioscorea bulbifera L. (DB). DLB is able to cause severe liver injury. The early studies showed that CYP3A4-mediated metabolic activation of DLB to form the corres...
Response to Dr. Ivonne M.C.M. Rietjens' letter regarding "Effect of Parental perinatal exposure to L-Glutamate monosodium salt monohydrate on developmental neurotoxicity in rat offspring" [0.03%]
伊von妮·里特詹斯博士关于“母孕期和新生儿期食用L-单钠谷氨酸 hydrate对大鼠子代发育神经毒性影响”一文的回信
Zizhao Huang,Xiao Xiao,Xuan Zhang et al.
Zizhao Huang et al.
Mechanism of lncRNA CYTOR/miR-24-3p in sevoflurane-mediated cardiomyocyte protection against hypoxia/reoxygenation injury in cardiomyocytes [0.03%]
七氟醚介导的长链非编码RNA CYTOR/miR-24-3p信号通路在心肌细胞缺血再灌注损伤中的作用机制研究
Yanhong Liu,Xiaochun Feng,Xiaoxiao Dai et al.
Yanhong Liu et al.
Background: Sevoflurane (SEV) demonstrates cardiac protection, but its mechanism remains unclear. Long non-coding RNA CYTOR (LncRNA CYTOR) expression is altered in damaged heart cells and may promote disease, yet SEV- Lnc...
Matairesinol regulates TGF-β-induced EMT and TGF-β associated crosstalk with Wnt Signaling in PC3 prostate cancer cells: An omics-guided therapeutic insight [0.03%]
马苔树脂酚通过转录组学和蛋白组学机制研究调节PC3前列腺癌细胞中TGF-β诱导的上皮间质转化及TGF-β相关Wnt信号通路异常交互作用：一种以组学为导向的新治疗思路
Rama Rajadnya,Prajakta Patil,Akshay Deotare et al.
Rama Rajadnya et al.
Metastatic, castration-resistant prostate cancer (mPC) is driven by epithelial-to-mesenchymal transition (EMT), acquisition of stem-like traits, and resistance to apoptosis, processes orchestrated by TGF-β and reinforced by Wnt/β-catenin ...