Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure [0.03%]
怀孕妇女体内铅的生理基毒性动力学模型的发展：骨组织在母体和胎儿内部暴露中的作用
Yourdasmine Ali Daoud,Cleo Tebby,Rémy Beaudouin et al.
Yourdasmine Ali Daoud et al.
Epidemiological studies have shown associations between prenatal exposure to lead (Pb) and neurodevelopmental effects in young children. Prenatal exposure is generally characterized by measuring the concentration in the umbilical cord at de...
Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating AhR-TLS-promoted genomic instability in human colon cancer cells [0.03%]
CK2靶向联合用药通过抑制AhR-TLS诱导的基因组不稳定性来克服人类结肠癌细胞对5-氟尿嘧啶耐药性
Zhiwei Wang,Feihong Chen,Yuanjiang Wang et al.
Zhiwei Wang et al.
As highly expressed in several human cancers, Casein Kinase 2 (CK2) is involved in chemotherapy-induced resistance. As a new potent CK2 inhibitor, DN701 is used to overcome chemoresistance through its synergistic antitumor effect with 5-flu...
A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways [0.03%]
四种接触致敏物对THP-1细胞蛋白质组的比较分析显示其关键代谢途径产生不同的改变
Tessa Höper,Isabel Karkossa,Verónica I Dumit et al.
Tessa Höper et al.
Allergic contact dermatitis (ACD) is the predominant form of immunotoxicity in humans. The sensitizing potential of chemicals can be assessed in vitro. However, a better mechanistic understanding could improve the current OECD-validated tes...
Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation [0.03%]
乌索酸通过抑制凋亡和恢复成骨分化治疗激素所致股骨头缺血性坏死研究（小鼠模型）
Qian Liu,Yuyang Wu,Sisi Li et al.
Qian Liu et al.
Steroid-induced avascular necrosis of femoral head (SANFH) is a common disorder worldwide with high disability. Overdose of glucocorticoid (GC) is the most common non-traumatic cause of SANFH. Up until now, there are limited therapeutic str...
Toxicological and biochemical mechanisms of pesticides in non-targeted biological systems [0.03%]
农药在非目标生物系统中的毒理学和生化机制研究进展
Ariane Zamoner,Maria L Pereira,Marco G Alves
Ariane Zamoner
Study of Huperzine A derivatives with extended protection against soman intoxication [0.03%]
研究有效延长霍山绞股蓝碱衍生物对抗沙林中毒的保护作用
Yalan Cui,Xuejun Chen,Jingjing Shi et al.
Yalan Cui et al.
Pre-administration of huperzine A (Hup A) was validated to prevent poisoning from exposure to nerve agents (NAs) by reversibly inhibiting acetylcholinesterase (AChE). However, like the currently commonly used reversible inhibitors, Hup A ha...
CD19 chimeric antigen receptor T cell therapy in leukemia xenograft mouse: Anti-leukemic efficacy, kinetics, and 4-week single-dose toxicity [0.03%]
嵌合抗原受体修饰的T细胞(CD19 CAR-T)治疗白血病异种移植小鼠：抗白血病效应、动力学及单次给药四周毒性研究
Joo-Il Kim,Mi-Young Park,Euna Kwon et al.
Joo-Il Kim et al.
CD19 Chimeric antigen receptor T (CAR-T) cell therapy has shown a promising response rate for relapsed/refractory B-cell malignancies. However, serious side effects such as cytokine release syndrome and immune effector cell-associated neuro...
Effects of heated tobacco product aerosol extracts on DNA methylation and gene transcription in lung epithelial cells [0.03%]
加热烟草产品气溶胶提取物对肺上皮细胞DNA甲基化和基因转录的影响
Ayami Sato,Akihito Ishigami
Ayami Sato
Aims: Smoking causes DNA methylation (DNAm) alterations that lead to lung cancer development. Although the use of heated tobacco products (HTPs) has recently increased, their impact on health remains unclear. This study a...
Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase [0.03%]
虚拟筛选与生物活性评价识别潜在抑制类固醇11β-羟基化酶引起高血压和低血钾的药物
Marie-Christin Jäger,Jacek Kędzierski,Victoria Gell et al.
Marie-Christin Jäger et al.
Several drugs were found after their market approval to unexpectedly inhibit adrenal 11β-hydroxylase (CYP11B1)-dependent cortisol synthesis. Known side-effects of CYP11B1 inhibition include hypertension and hypokalemia, due to a feedback a...
Cadmium reduces growth of male fetuses by impairing development of the placental vasculature and reducing expression of nutrient transporters [0.03%]
镉通过破坏胎盘血管的发育并降低营养运输载体的表达来抑制男性胎儿生长
Danielle Kozlosky,Alexander Lu,Cathleen Doherty et al.
Danielle Kozlosky et al.
In utero exposure to the toxic metal cadmium (Cd) alters fetoplacental growth in rodents and has been inversely associated with birth weight and infant size in some birth cohorts. Moreover, studies suggest that Cd may have differential effe...