Jacqui Marzec,Srikanth S Nadadur
Jacqui Marzec
Laurie G Hudson,Matt Campen,Ke Jian Liu
Laurie G Hudson
Effects of fungicides on the ultrastructure of the hypopharyngeal glands and the strength of the hives of Apis mellifera Linnaeus, 1758 (Hymenoptera: Apidae) [0.03%]
杀菌剂对Apis mellifera Linnaeus, 1758（膜翅目：蜜蜂科）下腭腺的超微结构和蜂群强度的影响
Adriana Chaves,Márcia Regina Faita,Rubens Onofre Nodari
Adriana Chaves
Several crops of agronomic interest depend on bees' pollination, and Apis mellifera L (Hymanoptera: Apidae) is the most studied direct pollinator. Nevertheless, the use of pesticides in agricultural environments is common, including fungici...
Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning [0.03%]
基于人iPSC来源的心肌细胞和机器学习的钙瞬变产生的正性肌力效应预测
Hongbin Yang,Olga Obrezanova,Amy Pointon et al.
Hongbin Yang et al.
Functional changes to cardiomyocytes are undesirable during drug discovery and identifying the inotropic effects of compounds is hence necessary to decrease the risk of cardiovascular adverse effects in the clinic. Recently, approaches leve...
Kevin Ho,David Weimar,Gina Torres-Matias et al.
Kevin Ho et al.
Asthma is a chronic inflammatory airway disease characterized by acute exacerbations triggered by inhaled allergens, respiratory infections, or air pollution. Ozone (O3), a major component of air pollution, can damage the lung epithelium in...
Crosstalk between the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor gamma (PPARγ) as a key factor in the metabolism of silver nanoparticles in neuroblastoma (SH-SY5Y) cells in vitro [0.03%]
芳烃受体(AhR)与过氧化物酶增殖激活受体 gamma (PPARγ) 之间的串扰作为体外神经母细胞瘤(SH-SY5Y) 细胞银纳米颗粒代谢的关键因素
Bartosz Skóra,Paulina Matuszewska,Martyna Masicz et al.
Bartosz Skóra et al.
The potential usefulness of silver nanoparticles (AgNPs) in anticancer therapy has been postulated for many years. However, little is known to date about the exact impact of such NPs on intracellular detoxication pathways. Therefore, the ai...
Preliminary study to classify mechanisms of mitochondrial toxicity by in vitro metabolomics and bioinformatics [0.03%]
通过代谢组学和生物信息学初步研究线粒体毒性机制的分类
Yui Hibino,Akira Iguchi,Kei Zaitsu
Yui Hibino
Aim: Mitochondrial toxicity is one of the causes for drug-induced liver injury, and the classification of phenotypes or mitochondrial toxicity are highly required though there are no molecular-profiling approaches for cla...
Metabolomics of V2O5 nanoparticles and V2O5 nanofibers in human airway epithelial BEAS-2B cells [0.03%]
V2O5纳米颗粒和V2O5纳米纤维在人呼吸道上皮细胞BEAS-2B中的代谢组学研究
Xiaojia He,Zachery R Jarrell,Matthew Ryan Smith et al.
Xiaojia He et al.
Vanadium is a toxic metal listed by the IARC as possibly carcinogenic to humans. Manufactured nanosize vanadium pentoxide (V2O5) materials are used in a wide range of industrial sectors and recently have been developed as nanomedicine for c...
Drug repurposing of ilepcimide that ameliorates experimental autoimmune encephalomyelitis via restricting inflammatory response and oxidative stress [0.03%]
通过限制炎症反应和氧化应激来改善实验性自身免疫性脑脊髓炎的药物ilepcimide的重新定位
Zhaomin Xu,Sisi Lu,Xi Liu et al.
Zhaomin Xu et al.
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that remains incurable. Herein, we demonstrated that ilepcimide (Antiepilepsirine), an antiepileptic drug used for decades, protects mi...
Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition [0.03%]
维生素D改善二乙基亚硝胺诱导的肝脏癌前病变：通过DPP-4酶抑制，CYP3A4/CYP2E1发挥关键作用
Hebatollah E Eitah,Hanan Naeim Attia,Ahmed A F Soliman et al.
Hebatollah E Eitah et al.
Growing evidence has indicated that vitamin D (Vit D) regulates cell proliferation and differentiation in cancer cells. Accordingly, the present study was conducted to investigate the possible beneficial effects of Vit D on diethylnitrosami...