Combined acylated catalpol diglycoside and Lactobacillus therapy restores the miR-146a-TRAF6-SIRT1/AMPK signaling axis in experimental colitis [0.03%]
酰化柴胡皂苷双糖苷和乳酸菌联合治疗通过调节miR-146a-TRAF6-SIRT1/AMPK信号轴修复实验性结肠炎
Ahmed M El-Baz,Reham M Goda,Hany N Baraka et al.
Ahmed M El-Baz et al.
Inflammatory bowel disease is characterized by altered innate immunity, oxidative stress, and gut microbiota imbalance. This study explored the association between miR-146a expression and the TRAF6-NF-κB-SIRT1-AMPK axis and assessed the th...
Nitroxoline attenuates sepsis-associated pancreatic injury through inhibiting NLRP3-inflammasome mediated pyroptosis [0.03%]
硝唑吡哃通过抑制NLRP3炎症小体介导的细胞焦亡减轻脓毒症相关性急性胰腺损伤
Tingzi Gong,Xiaohui Zeng,Cheng Li et al.
Tingzi Gong et al.
Objective: Pancreatic injury constitutes a prevalent and clinically critical complication in the setting of sepsis, typified by both an increased occurrence and a substantial mortality risk. This study investigated the me...
Arylacetamide deacetylase attenuates hepatic lipid accumulation under ER stress conditions by regulating iron-dependent oxidative stress [0.03%]
芳基乙酰胺脱乙酰酶通过调节铁依赖性氧化应激在内质网应激条件下减轻肝脏脂质积累
Mai Nagaoka,Miyu Watanabe,Chieri Fujino et al.
Mai Nagaoka et al.
Arylacetamide deacetylase (AADAC) is a drug-metabolizing enzyme that catalyzes the hydrolysis of clinical drugs containing an acetyl moiety. Recent in vitro studies have suggested that AADAC also reduces intracellular lipid accumulation; ho...
Irisin alleviates ferroptosis in LPS-induced acute kidney injury via regulating FGL2 [0.03%]
irisin通过调节FGL2缓解LPS诱导的急性肾损伤中的铁死亡
Supei Yin,Yin Wang,Dongli Huang et al.
Supei Yin et al.
Sepsis-associated acute kidney injury (SA-AKI) is significantly associated with high morbidity and mortality rates. Emerging evidence has suggested that ferroptosis plays a key role in AKI. It has been also reported that irisin exerts anti-...
Indole-3-Carbinol (I3C) suppression of IgG2b-triggered signaling in innate cells involves early suppression of p-Akt [0.03%]
吲哚-3-甲醇(I3C)对固有免疫细胞中IgG2b触发的信号转导早期抑制p-Akt
Arpita Deb,Audrey Miceli,Barbara L F Kaplan
Arpita Deb
Immunoglobulin G (IgG) plays a crucial role in immune defence mechanisms, yet IgG antibodies can contribute to the pathology of autoimmune diseases like multiple sclerosis (MS). Our prior work demonstrated that the aryl hydrocarbon receptor...
Puerarin inhibits SiO2-induced pulmonary epithelial-mesenchymal transition via suppressing NF-κB activation: Insights from network pharmacology and experiment validation [0.03%]
网络药理学和实验验证指导下的大豆黄素通过抑制NF-κB活化干预SiO₂诱导的肺上皮间质转化研究
Shengpeng Wen,Kai Wang,Qiushi Wang et al.
Shengpeng Wen et al.
Silicosis is a progressive and irreversible occupational pulmonary fibrotic disease for which no clinically available agents can effectively reverse established fibrosis. Puerarin (PUE), a natural isoflavonoid, has previously been demonstra...
Gut microbiome-related tryptophan metabolites modulate drug transporters, with prominent effects on OAT1 and OAT3 [0.03%]
肠道微生物群相关的色氨酸代谢物调节药物转运蛋白，对OAT1和OAT3的影响尤为显著
Min-Ji Kang,Kyeong-Ryoon Lee,Min Ju Kim et al.
Min-Ji Kang et al.
The gut microbiome plays a key role in tryptophan metabolism by directly generating indole derivatives and indirectly modulating the host-driven kynurenine pathway via microbial metabolites. In this study, we examined the effects of 12 gut ...
Harnessing plant-derived bioactive compounds as LOX-1 inhibitors in Helicobacter pylori-driven gastric inflammation [0.03%]
利用植物衍生的生物活性化合物作为LOX-1抑制剂以治疗幽门螺旋杆菌驱动的胃炎
Nfor Gael Njini,Siddharth Singh,Harshita Shrivastava et al.
Nfor Gael Njini et al.
Helicobacter pylori persistence and rising antibiotic resistance have intensified interest in host-directed adjunctive strategies. Recent studies identify LOX-1 as a gastric epithelial receptor for H. pylori catalase and support its role in...
Paroxetine attenuates doxorubicin-induced cardiotoxicity: Integrated network pharmacology, molecular modeling, and in vivo evidence consistent with modulation of GRK2/iNOS-related pathways [0.03%]
帕罗西汀通过调节GRK2/iNOS相关途径减轻阿霉素引起的心脏毒性：整合网络药理学、分子建模和体内证据
Mahmoud Nabil,Rasha Abdel-Ghany,Nader E Abo-Dya et al.
Mahmoud Nabil et al.
Doxorubicin is a potent chemotherapeutic agent whose clinical utility is compromised by dose-dependent, irreversible cardiotoxicity. Given the limitations of current cardioprotective strategies regarding efficacy and safety, repurposing app...
Novel GLP-1RA-like effects of Bafetinib: a preliminary study integrated in vitro screening and in vivo validation [0.03%]
巴非替尼具有类似GLP-1RA的作用：一项初步结合体外筛选和体内验证的研究
Xin Zheng,Quantong Xu,Yadong Wei et al.
Xin Zheng et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are first-line treatments for type 2 diabetes mellitus and obesity. Nevertheless, their clinical application is constrained by the adimistration route of subcutaneous injection and the sa...