Zingiberensis new saponin reverses sorafenib resistance by targeting lncRNA TCONS-00026762/AKR1C1 and modulating autophagy and ferroptosis in hepatocellular carcinoma [0.03%]
姜根新皂苷通过靶向长链非编码RNA TCONS-00026762/AKR1C1并调节自噬和铁死亡逆转肝细胞癌索拉非尼耐药性
Liang Luo,Pingsheng Zhou,Keqing He
Liang Luo
Introduction: Zingiberensis new saponin (ZnS) extracted from Dioscorea zingiberensis has antitumor activity. Our previous study found that Zns could exert anti- hepatocellular carcinoma (HCC) effects by regulating lncRNA ...
High-density lipoprotein cholesterol protects against delayed encephalopathy after acute carbon monoxide poisoning [0.03%]
高密度脂蛋白胆固醇可预防急性一氧化碳中毒后迟发性脑病
Yuhang Mu,Nan Gao,Yutao Wang et al.
Yuhang Mu et al.
High-density lipoprotein cholesterol (HDL-C) plays a crucial role in neurological disorders. In this study, we aimed to elucidate the role of HDL-C in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP), which presents wit...
Nanocapsule-based vitamin B12 as a novel strategy against vancomycin-induced nephrotoxicity: Targeting oxidative stress, ER stress, inflammation, and fibrosis in rats [0.03%]
基于纳米胶囊的维生素B12作为对抗万古霉素诱导的肾毒性的新型策略：在大鼠中靶向氧化应激、内质网应激、炎症和纤维化
Mahran Mohamed Abd El-Emam,Maha S Kilany,Mohamed Ibrahim et al.
Mahran Mohamed Abd El-Emam et al.
Vancomycin (VCM) is an essential glycopeptide antibiotic employed for treating methicillin-resistant Staphylococcus infections. However, its clinical use is limited by nephrotoxicity. Vitamin B12 (Vit B12) possesses antioxidant, anti-inflam...
Drug screening reveals the mechanism of toyocamycin-induced apoptosis in triple-negative breast cancer organoids [0.03%]
药物筛选揭示了toyocamycin诱导的三阴性乳腺癌类器官凋亡的机制
Houshi Ma,Linlin Lu,Yuqing Tu et al.
Houshi Ma et al.
Triple-negative breast cancer (TNBC) is characterized by high aggressiveness and molecular heterogeneity, limiting therapeutic efficacy and drug resistance, necessitating reliable preclinical models and novel therapeutic agents. This study ...
miR-207 mitigates silica-induced pulmonary fibrosis by suppressing fibroblast-to-Myofibroblast transition via multi-target modulation of the TGF-β1/SMADs signaling pathways in mice [0.03%]
微RNA-207通过多靶标抑制转化生长因子-β1/smad信号途径缓解小鼠硅肺纤维化
Shu-Ling Du,Yuan-Yuan Cui,Xuan Zhou et al.
Shu-Ling Du et al.
TGF-β1/SMADs signaling pathway plays a vital role in development of silicosis, with SMADs serving as the core transducers. Accordingly, any fluctuation in SMAD abundance can decisively steer the disease trajectory. Our previous research re...
Integrated assessment of the effects of PFOA exposure on hepatic transcriptome and lipid profiles in mice expressing human PPARα [0.03%]
以人PPARα基因为靶点的小鼠肝转录谱及脂质轮廓的全基因组整合分析PFOS和PFOA暴露效应的研究
G Nielsen,E Reed,B Lara et al.
G Nielsen et al.
Per- and polyfluoroalkyl substances (PFAS) are a family of persistent chemicals that continue to be released pervasively into the environment, leading to widespread human exposure. Emerging epidemiological evidence shows adverse effects on ...
Nomilin ameliorates perfluorooctanoic acid (PFOA)-induced impairment of zebrafish (Danio rerio) ocular development and visual function through PIK3CA activation [0.03%]
Nomilin通过激活PIK3CA改善全氟辛酸(PFOA)诱导的斑马鱼(Danio rerio)眼睛发育和视觉功能障碍
Xing Liu,Mingzhu Xia,Xinyi Wu et al.
Xing Liu et al.
Perfluorooctanoic acid (PFOA), a pervasive environmental contaminant, is implicated in ocular diseases through prenatal/embryonic exposure. This study investigated the protective effects of nomilin, a citrus-derived bioactive compound with ...
Nitazoxanide reverses pulmonary vascular remodeling in pulmonary hypertension by targeting the IMPA1-RAGE signaling axis [0.03%]
尼他唑烷通过靶向IMPA1-RAGE信号轴逆转肺动脉高压中的肺血管重塑
Di Wang,Ning Huang,Mingyuan Cai et al.
Di Wang et al.
Pulmonary hypertension (PH) is a life-threatening disorder characterized by excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), leading to pulmonary vascular remodeling, elevated pulmonary vascular resist...
circSHOC1-SLC25A3 promotes 2-naphthylamine-induced DNA damage in bronchial epithelial cells via activation of oxidative stress [0.03%]
圆盘状颗粒细胞癌及交界性肿瘤指南(2021年版)
Yan Jiang,Jiayu Zhou,Shusen Fang et al.
Yan Jiang et al.
Smoking, a pivotal environmental risk factor, drives diseases including lung cancer through genetic and epigenetic alterations. While 2-Naphthylamine (2-NA), a tobacco-derived carcinogen, is established as a bladder carcinogen via DNA damag...
Activated autophagy drives the adaptive response to LPS-evoked lung pyroptosis in adolescent mice [0.03%]
活化的自噬驱动小鼠青春期肺pyroptosis的适应性反应
Hao Li,Hua Wang,Ye-Xin Luo et al.
Hao Li et al.
The disease of lipopolysaccharide (LPS)-induced acute lung injury (ALI) is prevalent among clinical respiratory patients. The LPS adaptive response is a phenomenon whereby prior exposure to a low dose of LPS results in insensitivity to a su...