Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification [0.03%]
光气吸入损伤的小鼠模型：模拟人类病理生理、生物标志物发现和治疗靶点识别
Sarah M Long,Ana I Caceres,Alan D Marcus et al.
Sarah M Long et al.
Phosgene gas (choking gas (CG), military designation) has been used as a terrorist weapon, in warfare, and has injured many in transportation or industrial accidents. Phosgene inhalation exposure causes severe pulmonary edema and lung injur...
Disruption of progesterone synthesis by PBDEs: Potent inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase by the metabolite 4-Bromodiphenyl ether [0.03%]
多溴二苯醚对孕酮合成的干扰：溴化二苯醚抑制人和大鼠胎盘3β-羟基类固醇脱氢酶的作用
Lubin Xie,Qianjin Fei,Ming Su et al.
Lubin Xie et al.
Polybrominated diphenyl ethers (PBDEs) and their metabolite 4-bromodiphenyl ether (BDE3) are pervasive environmental contaminants suspected of endocrine-disrupting effects. This study investigates their inhibitory potential and mechanism of...
Corrigendum to 'Time-resolved transcriptomic responses delineate liver injury, immune-mediated clearance, and regeneration following microcystin-LR exposure in whitefish: implications for an uptake-limiting defense response (autokleisis)' [Toxicology and Applied Pharmacology 514 (2026) 117934] [0.03%]
“时间分辨转录组响应阐明微囊藻毒素-LR暴露下白鱼肝损伤、免疫清除和再生的时间进程：对自噬限制防御反应（autokleisis）的启示”[毒理学与应用药理学 514 (2026) 117934]的勘误表
Maciej Woźny,Jan P Jastrzębski,Bogdan Lewczuk et al.
Maciej Woźny et al.
Published Erratum
Toxicology and applied pharmacology. 2026 Aug 7:117986. DOI:10.1016/j.taap.2026.117986 2026
F-box only protein 10 protects against pathological myocardial hypertrophy by counteracting ferroptotic cell death in cardiomyocytes via destabilization of ACSL4 [0.03%]
F-框唯一蛋白10通过使心肌细胞中的ACSL4不稳定来抵抗铁死亡从而保护病理性的心肌肥厚
Xia Chen,Xihui Wang,Xiaochun Lei
Xia Chen
Pathological cardiac hypertrophy serves as a key contributor to the onset and progression of heart failure, with cardiomyocyte death serving as its key pathological underpinning. Ferroptosis has recently emerged as an important mechanism in...
Liquiritigenin attenuates high-salt diet-induced neuroinflammation, mitochondrial dysfunction, and cognitive impairment via NF-κB pathway inhibition [0.03%]
甘草素通过抑制NF-κB信号途径缓解高盐膳食诱导的神经炎症、线粒体功能障碍和认知损伤
Yedan Liu,Dezhi Xu,Yun Shi et al.
Yedan Liu et al.
Liquiritigenin (LG), a flavonoid compound extracted from licorice, possesses diverse pharmacological activities, including anti-inflammatory and antioxidant effects. A high-salt diet (HSD) is a common dietary risk factor associated not only...
Integrated metabolomic and behavioral profiling reveals neurotoxicity signatures in zebrafish larvae exposed to pharmaceutical compounds [0.03%]
整合代谢组学和行为学特征揭示药物化合物暴露对斑马鱼幼鱼神经毒性的标志物
Pavel M Rezvanov,Natalia E Moskaleva,Elizaveta G Appolonova et al.
Pavel M Rezvanov et al.
Early detection of neurotoxicity remains a challenge, as functional disturbances often precede overt morphological abnormalities. Zebrafish (Danio rerio) larvae provide a suitable in vivo model for integration of behavioral and biochemical ...
Integrated network pharmacology, molecular docking, and experimental validation reveal synergistic inhibition of EGFR and PI3K-Akt/JAK2-STAT3 pathways by Esculin and Esculetin to exert anti-colorectal cancer effects [0.03%]
网络药理学、分子对接和实验验证的综合研究揭示了埃斯卡灵和埃斯큘灵通过协同抑制EGFR和PI3K-Akt/JAK2-STAT3途径发挥抗结直肠癌作用
Lin Liao,Zhaohui Tang,Pengfei Luo et al.
Lin Liao et al.
Colorectal cancer (CRC) remains a global health challenge with limited efficacy of single-target therapies. Esculin and esculetin, the main coumarins of Cortex Fraxini, have been reported to exhibit anti-tumor activities in various cancer c...
Corrigendum to "Doxorubicin-induced cardiotoxicity under 28 GHz 5G-band electromagnetic radiation in rats: Insights into the mitigative role of vitamin C" [Toxicology and Applied Pharmacology 507(2026) 117703] [0.03%]
关于“维生素C对28GHz 5G频段电磁辐射诱发的多柔比星心毒性作用的缓解作用研究”的勘误[毒理学与应用药理学507(2026)117703]
Atefeh Rahimi,Ali Rafati,S M J Mortazavi et al.
Atefeh Rahimi et al.
Published Erratum
Toxicology and applied pharmacology. 2026 Aug 4:117982. DOI:10.1016/j.taap.2026.117982 2026
Integrated approaches to testing and assessment (IATA) for the estrogenic response of 14 commonly used chemicals in consumer products [0.03%]
用于消费者产品的14种常用化学品的雌激素反应综合测试和评估方法(IATA)
Hyun Jun Lee,Darlene Mae Ortiz,Kwangsik Park
Hyun Jun Lee
Human exposure to functional ingredients in consumer products is chronic and often involves complex mixtures; however, integrated assessments of their endocrine-related effects remain limited. This study utilized an adverse outcome pathway ...
The study of intestinal toxicity induced by gossypol acetic acid and the mechanism using zebrafish model and network toxicology [0.03%]
丙酸棉酚致肠毒性及机制的网络毒理学研究——斑马鱼模型的应用
Hanxue Zhao,Yuxin Wang,Guoliang Zhang et al.
Hanxue Zhao et al.
Gossypol acetic acid (GAA), a natural product obtained from the cottonseed, has various bioactivities, including antiviral, anti-tumor and anti-inflammatory properties, among others. However, the potential intestinal toxicity of GAA is poor...