An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance [0.03%]
抗疟疾药物耐药性进化过程中基因搭车的分析模型
Kristan A Schneider,Yuseob Kim
Kristan A Schneider
We analytically study a deterministic model for the spread of drug resistance among human malaria parasites. The model incorporates all major characteristics of the complex malaria transmission cycle and accounts for the fact that only a fr...
On the reproductive value and the spectrum of a population projection matrix with implications for dynamic population models [0.03%]
关于人口投影矩阵的生殖值及其谱在动态人口模型中的应用含义方面的研究
Dalkhat M Ediev
Dalkhat M Ediev
The eigenvalues of a population projection matrix-except for the Lotka coefficient-are uniquely determined by the reproductive values and the survival. This relation (proposed earlier, but not really well known in western literature) follow...
Sufficiency of the number of segregating sites in the limit under finite-sites mutation [0.03%]
有限位点突变下的无限位点模型的有效性——平衡种群中分离位点数量的极限性质
Arindam Roychoudhury,John Wakeley
Arindam Roychoudhury
We show that the number of segregating sites is a sufficient statistic for the scaled mutation parameter (theta) in the limit as the number of sites tends to infinity and there is free recombination between sites. We assume that the mutatio...
Markus Riester,Peter F Stadler,Konstantin Klemm
Markus Riester
We present a Bayesian method for the reconstruction of pedigrees in clonal populations using co-dominant genomic markers such as microsatellites and single nucleotide polymorphisms (SNPs). The accuracy of the algorithm is demonstrated for s...
Evolution and polymorphism in the multilocus Levene model with no or weak epistasis [0.03%]
低表型互作下的多基因Levene模型中的进化与多重适应性峰现象
Reinhard Bürger
Reinhard Bürger
Evolution and the maintenance of polymorphism under the multilocus Levene model with soft selection are studied. The number of loci and alleles, the number of demes, the linkage map, and the degree of dominance are arbitrary, but epistasis ...
Rick Durrett,Jasmine Foo,Kevin Leder et al.
Rick Durrett et al.
Most human tumors result from the accumulation of multiple genetic and epigenetic alterations in a single cell. Mutations that confer a fitness advantage to the cell are known as driver mutations and are causally related to tumorigenesis. O...
Estimating the kernel parameters of premises-based stochastic models of farmed animal infectious disease epidemics using limited, incomplete, or ongoing data [0.03%]
利用有限的、不完整的或正在进行的数据估计养殖动物传染病流行基于群组的随机模型的核心参数值
Chris Rorres,Sky T K Pelletier,Matt J Keeling et al.
Chris Rorres et al.
Three different estimators are presented for the types of parameters present in mathematical models of animal epidemics. The estimators make use of the data collected during an epidemic, which may be limited, incomplete, or under collection...
Feng Yu,Alison Etheridge
Feng Yu
Suppose that a beneficial mutation is undergoing a selective sweep when another beneficial mutation arises at a linked locus. We study the fixation probability of the double mutant, i.e., one (produced by recombination) that carries both mu...
Yun Kang,Peter Chesson
Yun Kang
We modify the commonly used invasibility concept for coexistence of species to the stronger concept of uniform invasibility. For two-species discrete-time competition and predator-prey models, we use this concept to find broad easily checke...
Developmental variability and stability in continuous-time host-parasitoid models [0.03%]
连续时间寄主-寄生模型中的发展变异性及稳定性
Dashun Xu,John D Reeve,Xiuquan Wang et al.
Dashun Xu et al.
Insect host-parasitoid systems are often modeled using delay-differential equations, with a fixed development time for the juvenile host and parasitoid stages. We explore here the effects of distributed development on the stability of these...