Electrochemical Strategies for Decoding Serotonin using Advanced Carbonaceous and 5th Generation Materials: A Comprehensive Review [0.03%]
基于先进碳质及第5代材料的电化学策略解析血清素研究综述
Rimpa Mondal,Sk Faruque Ahmed,Nillohit Mukherjee
Rimpa Mondal
Carbonaceous materials are placed in the category of advanced and future materials for their very unique physicochemical attributes like tuneable electronic, electrical and optical properties associated with good chemical reactivity, biocom...
Revisiting phenylketonuria: Do high brain glycine levels caused by chronic hyperphenylalanemia contribute to brain dysfunction by modulating D-serine levels and NMDA receptor activity? [0.03%]
PKU再探：慢性高苯丙氨酸血症引起的脑部甘氨酸水平升高通过调节D-丝氨酸水平和N-甲基-D天冬氨酸受体活性参与脑功能障碍？
Gerald A Dienel
Gerald A Dienel
Phenylketonuria (PKU) is an inborn error of metabolism owing to deficits in phenylalanine hydroxylase (PAH) activity. PKU children acquire irreversible brain damage if newborns are not identified and treated with a phenylalanine-restricted ...
Shweta Mishra,Ashlesha J Chauhan,Jayaveersinh Mahida
Shweta Mishra
Biosensors have become essential analytical tools that integrate biological recognition elements with physical transducers to detect specific analytes with remarkable sensitivity. This review delves into the applications of biosensors in he...
A Sensitive ELISA Made with Recombinant Antibodies for Cynomolgus IL-8 in Serum [0.03%]
一种用于食蟹猴血清中IL-8检测的重组抗体灵敏酶联免疫吸附法
Leting Yang,Xia Han,Xiao Zhu et al.
Leting Yang et al.
Accurate measurement of interleukin-8 (IL-8) in non-human primates is crucial for research into inflammation and tumors; however, sensitive enzyme-linked immunosorbent assays (ELISAs) for non-clinical studies remain limited. We aimed to dev...
Glutaminase I and Glutamine Transaminase-ω-Amidase Pathways in Colorectal Cancer: Metabolic Reprogramming and Emerging Therapeutic Strategies [0.03%]
结直肠癌中的谷氨酰胺酶I和谷氨酰胺转氨酶-ω-氨基转移酶途径：代谢重编程与新兴的治疗策略
Sarah F Voor,Arthur J L Cooper,John T Pinto
Sarah F Voor
Colorectal cancer (CRC) cells exhibit a pronounced dependence on L-glutamine to support anabolic growth, redox balance, and mitochondrial metabolism, a phenomenon known as "glutamine addiction." The canonical glutaminase I pathway is mediat...
Understanding the mode of action of arsenic(III) on the fungus Neofusicoccum parvum: target protein identification [0.03%]
砷(Ⅲ)作用于葡萄穗霜霉菌的毒性机制研究及靶蛋白鉴定
Andréa Engel,Florence Ferrari,Maude Meyer et al.
Andréa Engel et al.
Before it was banned, sodium arsenite was the unique fungicide able to control fungi associated with grapevine trunk diseases. However, its mode of action has not been fully elucidated yet. This study focuses on the identification of arseni...
An ultrasensitive electrochemical immunosensor constructed via Ag-GO-Nf nanocomposites for the detection of pefloxacin [0.03%]
一种基于Ag-GO-Nf纳米复合材料构建的超灵敏电化学免疫传感器检测培氟沙星
Jiaojiao Zhang,Yankai Liu,Enping Liu et al.
Jiaojiao Zhang et al.
Pefloxacin (PEF), a third-generation quinolone antimicrobial drug, is widely used in fisheries and animal husbandry. However, overuse poses food safety hazards and serious threats to human health. In this study, a label-free electrochemical...
High-Performance Sn/AuNP-Based Spectroscopic Ellipsometric Sensor for Patulin [0.03%]
高性能Sn/AuNP基光椭偏仪式PAT探测传感器
Zafer Üstündağ,Sinem Tunçer Çağlayan,Mustafa Oguzhan Caglayan
Zafer Üstündağ
A label-free spectroscopic ellipsometric (SE) aptasensor was developed for ultra-sensitive patulin (PAT) detection on a tin (Sn) substrate modified via electrochemical grafting of a 4-mercaptobenzene diazonium-derived self-assembled monolay...
Highly sensitive luciferase-based assay with red fluorescent protein expression for accurate quantitative monitoring and real-time visualization of cell invasion [0.03%]
高灵敏度的基于萤火虫荧光素酶的测定技术结合红色荧光蛋白表达技术用于准确量化监测和实时观察细胞侵袭现象
Michael Lyngbæk Christensen,Tove Kirkegaard,Ismail Gögenur et al.
Michael Lyngbæk Christensen et al.
Background: Traditional migration and invasion assays like scratch, Transwell, and Boyden chamber are widely used but have disadvantages such as being time-consuming, lacking real-time monitoring, and relying on endpoint ...
H-Ferritin nanocages: refined strategy for optimized protein production and purification [0.03%]
改良的策略实现高效血清铁蛋白纳米笼的生产和纯化
Arianna Bonizzi,Marta Sevieri,Leopoldo Sitia et al.
Arianna Bonizzi et al.
H-ferritin (HFn) nanocages are promising tools in biomedical applications, yet producing sufficient injectable quantities remains challenging. To optimize production, we compared two lysis methods and purification protocols, focusing on the...