Imidazole stabilizes NAD(P)H and improves reductase assays under challenging conditions [0.03%]
咪唑可稳定NAD(P)H并在严苛条件下提高辅酶还元酶活性检测的准确度
Shengkai Yin,Litao Wang,Xian&#x;ai Shi et al.
Shengkai Yin et al.
The reduced form of nicotinamide adenine dinucleotide (NAD(P)H) is prone to hydrolysis and ring-opening degradation under high-temperature and acidic conditions, resulting in a loss of reducing power and substantial inaccuracies in enzymati...
Deep learning assisted cell electrical signal analysis in impedance cytometry [0.03%]
深度学习辅助阻抗细胞分析中的细胞电信号分析
Houchen Zhou,Zheng Zhou,Longlong Wang et al.
Houchen Zhou et al.
In this study, we developed BioFluxNet, a 1D CNN-based algorithm for automated analysis of raw electrical signals in impedance cytometry to directly classify cell types and quantify cell counts. The network comprises three functional blocks...
msCNN-PLM-FAD: Enhanced predicting FAD binding sites by using protein language representation combined with multiple separable windows convolutional neural networks [0.03%]
基于多分离卷积神经网络与蛋白质语言表示的FAD结合位点预测方法
Dinh-Quy Nguyen,Viet-Thanh Nguyen,Cam-Hong Ly et al.
Dinh-Quy Nguyen et al.
The FAD binding sites classification problem is crucial because it is directly related to many diseases, such as flavoprotein-associated diseases, developmental disorders, digestive and lipid metabolism abnormalities, anemia, cancer, cardio...
Electrochemical quantification of dopamine using a nanocomposite of silver nanoparticles-potassium modified graphitic carbon nitride (Ag/K-g-CN) [0.03%]
纳米银-钾修饰石墨氮化碳复合材料的电化学定量多巴胺传感器
Smriti Dogra,Saumya Dwivedi,Jaspreet Kaur Rajput et al.
Smriti Dogra et al.
Herein, a selective and sensitive electrochemical sensor based on silver nanoparticles-potassium modified graphitic carbon nitride (Ag/K-g-CN) was developed. The nanocomposite was synthesised via a combined thermal and solvothermal method f...
An indole-oxadiazole-derived fluorescent probe for the detection of the human serum albumin level in thoracic surgery [0.03%]
一种吲哚-氧氮杂环丁衍生物荧光探针用于胸部手术中人血清白蛋白水平检测
Hanzhang Sun,Guanglei Zuo,Yueming Wu et al.
Hanzhang Sun et al.
In this work, the fluorescent probe InOx-HSA was developed from an indole-oxadiazole derivative for the detection of the HSA level in thoracic surgery. The probe reported a ratio fluorescence response from 405 nm to 505 nm under the excitat...
Establishment of a homogeneous immunoassay for quantitative detection of total procollagen type 1 N-terminal propeptide [0.03%]
建立检测总I型前胶原N端肽的均相免疫测定法
Shanshan Cheng,Yuanmin Sun,Xiaohui Yang et al.
Shanshan Cheng et al.
Objective: To establish a homogeneous immunoassay for quantitative detection of total procollagen type 1 n-terminal propeptide (P1NP) in human serum. Meth...
A new paradigm in tuberculosis diagnostics: Biosensing advances for early detection of Mycobacterium tuberculosis [0.03%]
结核病诊断的新范式：用于早期检测结核分枝杆菌的生物传感技术进展
Pooja Khandelwal,Neelam Yadav,Arzoo Saini et al.
Pooja Khandelwal et al.
Tuberculosis (TB) remains one of the most serious and deadly infectious diseases worldwide. Despite being preventable and curable, it is responsible for increasing the annual fatality by millions. The situation is even more alarming in the ...
Physiological role of gamma-glutamyl transpeptidase: Demise of the gamma-glutamyl cycle [0.03%]
γ-谷氨酰转肽酶的生理作用：γ-谷氨酰循环的终结
Marie H Hanigan
Marie H Hanigan
Gamma-glutamyl transpeptidase (GGT) is an enzyme with a plethora of names and purported functions. The enzyme has long been identified with an amino acid transport system called the gamma-glutamyl cycle which was proposed in the 1970s. The ...
EnsemGlyPred: Intelligent prediction system for lysine glycation sites integrating deep semantic features and sequence information [0.03%]
基于深度语义特征和序列信息的赖氨酸糖基化位点智能预测系统EnsemGlyPred
Yun Zuo,Sifan Zhu
Yun Zuo
Motivation: Protein non-enzymatic glycation plays a crucial role in chronic diseases such as diabetes, atherosclerosis, and neurodegenerative diseases. Accurate identification of lysine glycation sites is essential for el...
A Word2Vec-ResNet Transfer Learning model for promoter prediction with dimensionality reduction and cross-domain knowledge integration [0.03%]
一种基于Word2Vec和ResNet的迁移学习模型用于启动子预测，该模型具有降维及跨领域知识整合功能
Jiale Fu,Xiao Liu
Jiale Fu
Promoter prediction is critical for deciphering transcriptional regulatory mechanisms. However, traditional one-hot encoding strategies suffer from dimensionality explosion with vocabulary expansion, while single-domain knowledge constraint...