IL-21 plays an important role in modulating "Th17-Treg" cell axis in leprosy Type 1 reactions [0.03%]
白细胞介素21在调节麻风反应期“Th17-Treg”轴中起重要作用
Chaman Saini,Leena Sapra,Asha Bhardwaj et al.
Chaman Saini et al.
Leprosy type 1 reaction (T1R) is a cell-mediated inflammatory reaction which involves skin and peripheral nerves in leprosy. Lesions with T1R have higher production of IL-17 cytokine from CD4+ T cells along with lower TGF-β producing FOXP3...
IL-6 family cytokines: An updated perspective on their broad pathophysiology [0.03%]
白细胞介素(IL)-6家族细胞因子：对它们的广泛病理生理学的新观点
Brendan J Jenkins
Brendan J Jenkins
Hemoperfusion during veno-venous ECMO in severe COVID-19 with IL-6 elevation [0.03%]
严重COVID-19合并IL-6升高的患者接受静脉ECMO治疗时行血液灌注吸附疗法
Giovanni Giordano,Francesco Alessandri,Francesco Pugliese
Giovanni Giordano
Sandra P Smieszek,Vasilios M Polymeropoulos,Christos M Polymeropoulos et al.
Sandra P Smieszek et al.
Genome-wide association studies have recently identified 3p21.31, with lead variant pointing to the CXCR6 gene, as the strongest thus far reported susceptibility risk locus for severe manifestation of COVID-19. In order the determine its ro...
Clinical Trial
Cytokine. 2022 Apr:152:155810. DOI:10.1016/j.cyto.2022.155810 2022
Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1β-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-κB and MAPKs signaling pathways and inducing apoptosis [0.03%]
制附子脂溶性生物碱通过抑制NF-κB和MAPK信号通路及诱导凋亡缓解Ⅱ型胶原诱导的急性自身免疫性关节炎炎症反应
Chaocheng Guo,Linfeng He,Naihua Hu et al.
Chaocheng Guo et al.
Background: Fuzi lipid-soluble alkaloids (FLA) is the main bioactive components extracted from the traditional Chinese medicine Aconiti Lateralis Radix Praeparata ("Fuzi" in Chinese), which has promising analgesic and ant...
The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice [0.03%]
小鼠I型白细胞介素-1受体促进与衰老相关的进行性心肌病的发展
Pratyush Narayan,Elefterios Trikantzopoulos,Eleonora Mezzaroma et al.
Pratyush Narayan et al.
Background: Aging is associated with metabolic and structural changes causing heart failure with preserved ejection fraction (HFpEF). Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging-related inflammat...
Elevated ATP, cytokines and potential microglial inflammation distinguish exfoliation glaucoma from exfoliation syndrome [0.03%]
升高的ATP、细胞因子和潜在的微胶质炎症可区分剥脱性青光眼和剥脱症
Sujith Kumar Pulukool,Sai Krishna Srimadh Bhagavatham,Vishnu Kannan et al.
Sujith Kumar Pulukool et al.
Glaucoma is the second leading cause of blindness. Exfoliation syndrome (XFN) is a risk factor for exfoliation glaucoma (XFG) which is a secondary open angle glaucoma. XFG is difficult to manage with a worse prognosis. Though 40% of the XFN...
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease [0.03%]
LADA患者循环细胞因子的时间依赖性效应：IL1-ra和IL-1beta的降低与疾病进展有关
Ingrid K Hals,Anneli Björklund,Hanne Fiskvik Fleiner et al.
Ingrid K Hals et al.
Background: Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been conc...
Randomized Controlled Trial
Cytokine. 2022 Mar:151:155792. DOI:10.1016/j.cyto.2022.155792 2022
Involvement of progranulin (PGRN) in the pathogenesis and prognosis of breast cancer [0.03%]
脯氨酸丰富亮氨酸拉链蛋白1在乳腺癌发生及预后中的作用机制研究
Daryush Purrahman,Mohammad-Reza Mahmoudian-Sani,Najmaldin Saki et al.
Daryush Purrahman et al.
Breast cancer constitute a common type of oncological disease with a highlighted mortality rate. In recent years, researchers have introduced progranulin (PGRN) as an novel potential biomarker and associated its function with higher risk fa...
Alejandro Diaz-Barreiro,Arnaud Huard,Gaby Palmer
Alejandro Diaz-Barreiro
Interleukin (IL)-38 is the least well-understood cytokine of the IL-1 family. Since its discovery twenty years ago, numerous studies have linked IL-38 to diverse pathologies, especially in the context of autoimmune and inflammatory processe...