Unveiling the role of trace elements in modulating inflammatory and oxidative pathways in CAG repeat-driven spinocerebellar ataxia [0.03%]
揭秘微量元素调节CAG重复驱动的脊髓小脑共济失调炎性及氧化途径的作用
Surbhi Singh,Deepika Joshi,Abhay Kumar Yadav et al.
Surbhi Singh et al.
Spinocerebellar ataxias are genetically inherited neurodegenerative disorders, primarily caused by CAG trinucleotide repeat expansions in genes. While these genetic mutations initiate disease onset, increasing evidence suggests that systemi...
Anakinra ameliorates insulin resistance and inflammation in a murine model of gestational diabetes through downregulation of Th17 responses Anakinra for the treatment of GDM in mice [0.03%]
安卡拉通过下调Th17反应改善小鼠妊娠糖尿病的胰岛素抵抗和炎症
Lingyan Zhang,Fudan Huang,Shaik Althaf Hussain et al.
Lingyan Zhang et al.
Gestational diabetes mellitus (GDM) is associated with low-grade inflammation which can contribute to insulin resistance and dysregulated glucose metabolism. Anakinra is a recombinant form of IL-1 receptor antagonist (IL-1Ra) that has shown...
Sepsis-induced cardiac dysfunction: Gender bias role of allograft inflammatory factor-1 [0.03%]
性别偏见作用于同种异体移植物炎症因子-1的脓毒症诱导的心功能障碍
B C Wang,S Chaki,H Taufiq et al.
B C Wang et al.
Sepsis-induced cardiac dysfunction is a major contributor to the high morbidity and mortality rates seen in septic patients, with those suffering from concurrent cardiac dysfunction experiencing mortality rates up to 90 %. This study elucid...
Quercetin enhances amphotericin B activity and regulates ROS and cytokine production in human monocytes infected by Leishmania infantum [0.03%]
檞皮素增强鬼臼霉素B活性并调节Leishmania infantum感染的人单核细胞中的ROS和细胞因子产生
Leonardo Lima Cardoso,Delva Fonseca Lamec Thyares,Ana Letícia Monteiro Fernandes et al.
Leonardo Lima Cardoso et al.
Leishmania infantum, the main causative agent of zoonotic visceral leishmaniasis, persists and proliferates within host monocytes and macrophages. Numerous studies have focused on developing innovative therapies, as conventional treatments ...
Long-term storage stability of plasma TNF-α and IL-6 concentrations of psychiatric emergency patients: The Signature Biobank [0.03%]
精神科急诊患者血浆TNF-α和IL-6浓度的长期储存稳定性：生物库签名
Enzo Cipriani,Charles-Édouard Giguère,Cécile Le Page et al.
Enzo Cipriani et al.
Cytokines are increasingly incorporated in psychiatric research. While biobanking provides advantages for different study designs, long-term storage could degrade cytokine quality and introduce bias. To date, reports on cytokine stability a...
Clinical value of serum TNF-α and IL-2R as treatment predictive and prognostic biomarkers in metastatic colorectal cancer [0.03%]
血清TNF-α和IL-2R作为转移性结直肠癌治疗预后及预测生物标志物的临床价值
Jinxiu Tian,Jinjia Chang,Zhujun Chen et al.
Jinxiu Tian et al.
Background: Metastatic colorectal cancer remains a major global health concern, with advanced-stage disease posing significant challenges in terms of treatment and prognosis. Cytokines, key mediators of immune regulation ...
Ewura-Esi Manful,Francis Adu-Amankwaah,Abhilasha Madhvi et al.
Ewura-Esi Manful et al.
The interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is a crucial member of the interferon-stimulated gene (ISG) family, widely acknowledged for its antiviral activity. IFIT2 functions primarily through AU-rich RNA bindin...
Extracellular granzyme B and K are associated with endometriosis severity in infertile women [0.03%]
外泌体颗粒酶B和K与不孕症患者子宫内膜异位症严重程度相关性研究
Fadhil Ahsan,Budi Santoso,Nanda Yuli Rahmawati et al.
Fadhil Ahsan et al.
Background: Endometriosis is a chronic inflammatory condition often associated with infertility. The role of granzymes as cytotoxic proteases and immune regulators in endometriosis remains poorly understood. This study ev...
Inhibiting TGF-β signaling pathway for disease therapy: challenges and opportunities [0.03%]
转化生长因子-β信号通路在疾病治疗中的机遇与挑战
XiaoYan Gao,XiuDan Li,CongYing Zhang et al.
XiaoYan Gao et al.
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed in nearly all human tissues and cell types. The TGF-β signaling pathway is essential for embryonic development, cell and tissue differentiation, and tissue homeost...
The significance of serum IL-18 levels in Hodgkin lymphoma patients [0.03%]
霍奇金淋巴瘤患者血清IL-18水平的临床意义分析
Gülden Sincan,Suat Sincan,Çağrı Kızıltunç et al.
Gülden Sincan et al.
Background: Inflammation plays a crucial role in the pathogenesis of Hodgkin lymphoma. IL-18 is a proinflammatory cytokine. Therefore, we investigated the serum IL-18 levels and their prognostic significance in Hodgkin ly...