Interferon γ, IL-17, and IL-1β impair sperm motility and viability and induce sperm apoptosis [0.03%]
干扰素γ、白细胞介素17和白细胞介素1β损害精子运动性、存活率并诱导精子凋亡
Daniela Andrea Paira,Silene Silvera-Ruiz,Andrea Tissera et al.
Daniela Andrea Paira et al.
Urogenital inflammation is a known cause of male infertility. Increased levels of inflammatory cytokines, leukocyte counts and oxidative stress are highly detrimental for sperm quality thus compromising male fertility. Although cytokines af...
Aqueous extract of Passiflora alata leaves modulates in vitro the indoleamine 2,3-dioxygenase (IDO) and CD86 expression in bone marrow-derived professional antigen-presenting cells polarizing NOD mice T cells to a Treg profile [0.03%]
Passiflora alata叶子提取物通过下调骨髓来源专职抗原呈递细胞IDO和CD86的表达使NOD小鼠T细胞向Tregs表型极化作用机制研究
Nayara Simon Gonzalez Schumacher,Luís Gustavo Romani Fernandes,Ricardo de Lima Zollner
Nayara Simon Gonzalez Schumacher
Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (pAPCs), numerous in the pancreas of nonobese diabetic (NOD) mice and playing an essential role in the autoimmune response of type 1 diabetes. The expression of...
SOX4-activated lncRNA MCM3AP-AS1 aggravates osteoarthritis progression by modulating miR-149-5p/Notch1 signaling [0.03%]
SOX4激活的长链非编码RNA MCM3AP-AS1通过调节miR-149-5p/Notch1信号加重骨关节炎进展
Fei Xu,Qun-Fang Hu,Jia Li et al.
Fei Xu et al.
Objective: To clarify the expression and underlying network of long non-coding RNA (lncRNA) MCM3AP-AS1 in osteoarthritis (OA). Methods: ...
IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis [0.03%]
IL-17通过Act1/TRAF6/TAK1在实验性自身免疫心肌炎中上调MCP-1的表达
Xiao Huang,Zhuolun Li,Xinhe Shen et al.
Xiao Huang et al.
Myocarditis is a kind of myocardial inflammatory infiltration disease. Many interventions are not effective in the treatment of myocarditis because the mechanism of myocarditis has not been elucidated. Previous studies have found that inter...
Ghrelin polymorphism/TRPV1 receptor expression in Egyptian IBS patients [0.03%]
埃及IBS患者中ghrelin基因多态性/TRPV1受体表达的研究
Walaa Samy,Ahmed El Gebaly,Nabila H Ahmed et al.
Walaa Samy et al.
Introduction/objective: Irritable bowel syndrome is a functional gastrointestinal disorder. Ghrelin is a peptide hormone which affects gastrointestinal motility. We have studied the association between ghrelin gene polymo...
LncRNA ROR promotes NLRP3-mediated cardiomyocyte pyroptosis by upregulating FOXP1 via interactions with PTBP1 [0.03%]
长链非编码RNA ROR通过与PTBP1相互作用上调FOXP1促进NLRP3介导的心肌细胞焦亡
Min Zeng,Shijiang Yi,Yunbin Xiao et al.
Min Zeng et al.
Objective: The purpose of this design was to explore the specific role and related mechanism of long noncoding RNA (lncRNA) regulators of reprogramming (ROR) in viral myocarditis (VMC). ...
Hypoxia-related gene signature for predicting LUAD patients' prognosis and immune microenvironment [0.03%]
与低氧相关的基因特征用于预测LUAD患者的预后和免疫微环境
Jian Chen,Yin Fu,Jiangwei Hu et al.
Jian Chen et al.
Lung adenocarcinoma (LUAD) is a prevalent lung cancer histology with high morbidity and mortality. Moreover, assessment approaches for patients' prognoses are still not effective. Based on mRNA expression and clinical data from the Cancer G...
Lower levels of CXCL-8 and IL-2 on admission as predictors of early adverse reactions to Bothrops antivenom in the Brazilian Amazon [0.03%]
入院时CXCL-8和IL-2较低水平可预测巴西亚马逊地区Bothrops抗蛇毒血清的早期不良反应
Frandison G S Soares,Hiochelson N Ibiapina,Marco A Sartim et al.
Frandison G S Soares et al.
Snakebite envenomings are considered a global health problem. The specific therapy for these envenomings consists of administering animal-derived antivenoms aiming to neutralize the venom toxins. Antivenoms have been used effectively to tre...
SARS-CoV-2 infection causes intestinal cell damage: Role of interferon's imbalance [0.03%]
感染SARS-CoV-2导致肠细胞损伤：I型干扰素失衡的“双刃剑”作用机制
Stefany Guimarães Sousa,Antônio Kleiton de Sousa,Cynthia Maria Carvalho Pereira et al.
Stefany Guimarães Sousa et al.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the newly emerging lung disease pandemic COVID-19. This viral infection causes a series of respiratory disorders, and although this virus mainly infects ...
Systematic review and meta-analysis of human Toll-like receptors genetic polymorphisms for susceptibility to tuberculosis infection [0.03%]
toll样受体基因多态性易感结核病的系统评价和meta分析研究
Deepika Varshney,Shoorvir Singh,Ekata Sinha et al.
Deepika Varshney et al.
Epidemiological data from the world health organization (WHO) show that Globally an estimated 10 million (range, 8.9-11.0 million) people around the world were infected with TB in 2019. M.tuberculosis (M.tb) is the major cause of tuberculos...