Alterations of subset and cytokine profile of peripheral T helper cells in PBMCs from Multiple Sclerosis patients or from individuals with MS risk SNPs near genes CYP27B1 and CYP24A1 [0.03%]
多发性硬化患者或风险SNP近基因CYP27B1和CYP24A1个体外周血单个核细胞中T辅助细胞亚群及细胞因子谱的改变
Ming Lu,Hui Shi,Bruce V Taylor et al.
Ming Lu et al.
T helper cells play an important role in the aetiology of Multiple Sclerosis (MS). Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway express...
Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients [0.03%]
COVID-19患者中IFNAR1和TYK2转录物表达分析
Mohammadarian Akbari,Mehdi Akhavan-Bahabadi,Navid Shafigh et al.
Mohammadarian Akbari et al.
As a member of JAK family of non-receptor tyrosine kinases, TYK2 has a crucial role in regulation of immune responses. This protein has a crucial role in constant expression of IFNAR1 on surface of cells and initiation of type I IFN signali...
Recombinant guanosine-5'-triphosphate (GTP)-binding protein associated with Poloxamer 407-based polymeric micelles protects against Leishmania infantum infection [0.03%]
基于泊洛沙姆407的聚合物胶束递送重组GTP结合蛋白可抵抗利什曼原虫感染
Daniela P Lage,Amanda S Machado,Danniele L Vale et al.
Daniela P Lage et al.
Leishmania virulence proteins should be considered as vaccine candidates against disease, since they are involved in developing infection in mammalian hosts. In a previous study, a Leishmania guanosine-5'-triphosphate (GTP)-binding protein ...
Role of genetic polymorphisms in recurrent aphthous stomatitis: A systematic review and meta-analysis [0.03%]
复发性阿弗他溃疡中遗传多态性的作用：系统评价和Meta分析
Hila Yousefi,Morteza Gholami,Marziyeh Zoughi et al.
Hila Yousefi et al.
Recurrent aphthous stomatitis (RAS) is one of the most common oral ulcerative diseases with unknown etiology. Identifying the genetic markers can improve medical care and prevention of RAS. Genetics variants inflammatory agents are associat...
Meta-Analysis
Cytokine. 2022 May:153:155864. DOI:10.1016/j.cyto.2022.155864 2022
Group 3 innate lymphocytes (ILC3s) upregulate IL-22 in response to elevated intracellular cAMP levels [0.03%]
高胞内环磷酸腺苷水平通过CREM诱导III型固有淋巴样细胞产生更多的IL-22
Prakash Sah,Jonathan T Derouen,Justine L Alexander et al.
Prakash Sah et al.
Group 3 innate lymphocytes (ILC3s) are important immune cells within mucosal tissues and protect against bacterial infections. They can be activated in response to the innate cytokines IL-23 or IL-1β, which rapidly increases their producti...
The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia/reperfusion damage [0.03%]
核桃种子皮提取物对急性肾缺血再灌注损伤的肝肾保护潜力研究
Seda Askin,Hakan Askin,Elifnur Dursun et al.
Seda Askin et al.
Acute kidney damage is defined as a sudden change in kidney functions that prevents the removal of nitrogenous wastes from the body, thus disrupting the body's fluid and electrolyte balance. When acute kidney injury occurs, the kidneys and ...
HDAC3 promotes pulmonary fibrosis by activating NOTCH1 and STAT1 signaling and up-regulating inflammasome components AIM2 and ASC [0.03%]
组蛋白脱乙酰基酶3通过激活NOTCH1和STAT1信号通路及上调AIM2和ASC的表达促进肺纤维化
Qing Zheng,Yao Lei,Shan Hui et al.
Qing Zheng et al.
Background: Pre-clinical studies suggest that pan-inhibitors for histone deacetylases (HDACs) may benefit the treatment of pulmonary fibrosis (PF). However, HDAC3-specific roles or mechanisms during PF development are poo...
Liver transplantation for Hepatocellular Carcinoma: A prognostic model incorporating pretransplant inflammatory cytokines [0.03%]
肝细胞癌肝脏移植预后模型纳入移植前炎症细胞因子的影响
Ruiqi Sun,Liang Zhang,Zhentao Yang et al.
Ruiqi Sun et al.
Purpose: Liver transplantation (LT) remains an optimal treatment for selected hepatocellular carcinoma (HCC). Cytokines can be obtained by minimally invasive techniques and are associated with the development of HCC. The ...
TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-β/SMAD pathway [0.03%]
TRIM66通过调控MMP9介导的TGF-β/SMAD信号通路促进非小细胞肺癌恶性进展
Wenyu Chen,Ye Zhang,Zhixian Fang et al.
Wenyu Chen et al.
Objective: To investigate regulatory function and underlying mechanism of TRIM66 in non-small cell lung cancer (NSCLC). Methods: TRIM66...
Prognostic role of inflammatory cytokines and novel adipokines in acute myocardial infarction: An updated and comprehensive review [0.03%]
急性心肌梗死中炎症细胞因子和新型脂联素的预后作用：更新且全面的回顾
Andreas Mitsis,Nikolaos P E Kadoglou,Vaia Lambadiari et al.
Andreas Mitsis et al.
Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality worldwide. The inflammation response during and after AMI is common and seems to play a key role in the peri-AMI period, related with ischaemia-reperfus...