Evaluation of host biomarkers for monitoring treatment response in spinal tuberculosis: A 12-month cohort study [0.03%]
用于监测脊柱结核治疗反应的宿主生物标志物评价：一项为期12个月队列研究
Theresa N Mann,Johan H Davis,Caroline Beltran et al.
Theresa N Mann et al.
Background: Monitoring treatment response is an important precaution in spinal tuberculosis (TB), particularly when the condition was clinically diagnosed rather than bacteriologically confirmed and when drug susceptibili...
Inflammasomes and IL-1 family cytokines in SARS-CoV-2 infection: from prognostic marker to therapeutic agent [0.03%]
炎症小体和IL-1家族细胞因子在SARS-CoV-2感染中的作用：从预后标志物到治疗药物
Jozefien Declercq,Elisabeth De Leeuw,Bart N Lambrecht
Jozefien Declercq
Despite global vaccination programs, infections with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity and mortality. Severe coronavirus disease 2019 (COVID-19) is chara...
Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection [0.03%]
Th22细胞因子与黄热病：可能对人类肝炎免疫病理发病机制的影响
Caio Cesar Henriques Mendes,Jorge Rodrigues de Sousa,Fábio Alves Olímpio et al.
Caio Cesar Henriques Mendes et al.
Yellow fever (YF) is an infectious disease considered a public health problem in tropical and subtropical areas. YF has many pathophysiological events that are correlated with the host immune response. In this study, the in situ Th22 cytoki...
PD-1 inhibitor induces myocarditis by reducing regulatory T cells, activating inflammatory responses, promoting myocardial apoptosis and autophagy [0.03%]
PD-1抑制剂通过减少调节性T细胞、激活炎症反应、促进心肌凋亡和自噬诱导心肌炎
Ying-Xian Liu,Yan-Jun Song,Xiao-Hang Liu et al.
Ying-Xian Liu et al.
The present study aimed to explore the pathogenesis of autoimmune myocarditis induced by PD-1 inhibitors and their potential therapeutic targets. Mouse models of autoimmune myocarditis induced by PD-1 inhibitor in mouse models of polymyosit...
Engineering off-the-shelf universal CAR T cells: A silver lining in the cloud [0.03%]
现成通用型CAR-T细胞的工程化：拨开乌云见青天
Muthuganesh Muthuvel,Harshita Srinivasan,Leena Louis et al.
Muthuganesh Muthuvel et al.
CAR therapy holds promise in treating aggressive hematological malignancies. Nonetheless, the present autologous CAR therapy regimen makes multiple patients ineligible for the therapy due to inadequate quantity, quality and purity of the pr...
Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions [0.03%]
IL-36细胞因子在银屑病及其他炎症性皮肤病中的作用
Kacey L Sachen,Carrie N Arnold Greving,Jennifer E Towne
Kacey L Sachen
The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric receptor composed of IL-36R and the IL-1R accessory pr...
Interleukin-36α is elevated in diffuse systemic sclerosis and may potentiate fibrosis [0.03%]
白细胞介素-36α在弥漫性系统硬化症中升高并可能促进纤维化
Steven O&#x;Reilly
Steven O&#x;Reilly
Systemic sclerosis (SSc) is an autoimmune prototypical connective tissues disease that results in alterations in vasculature, inflammation and fibrosis of the skin. Interleukin-1 family cytokines has been implicated in the disease including...
Construction and validation of an immune-related LncRNA prognostic model for hepatocellular carcinoma [0.03%]
肝细胞癌免疫相关长链非编码RNA预后模型的构建与验证
Chang Xin,Bin Huang,Mingliang Chen et al.
Chang Xin et al.
Herein, based on mRNA data from TCGA database, hepatocellular carcinoma (HCC) samples were subjected to a single-sample Gene Set Enrichment Analysis (ssGSEA). Then, HCC samples were finally classified into high-, middle-, and low-immunity g...
MicroRNA-1-3p affects lung adenocarcinoma progression through E2F8 and regulating NF-кB pathway [0.03%]
微小核糖核酸-1-3p通过E2F8和调节NF-кB途径影响肺腺癌进展
Qingsheng Lin
Qingsheng Lin
E2F8 can modulate development and progression of various cancers including cervical cancer, breast cancer and hepatocellular carcinoma. But its mechanism in lung adenocarcinoma (LUAD) remains underexplored. In this study, we conducted a ser...
Hypoxia-driven metabolic heterogeneity and immune evasive behaviour of gastrointestinal cancers: Elements of a recipe for disaster [0.03%]
胃肠道癌症的低氧驱动代谢异质性和免疫逃避行为：灾难的要素 рецепты для катастрофы
Ashish Kumar Mishra,Siddharth Kumar Singh,Sruthilaya Dayanandan et al.
Ashish Kumar Mishra et al.
Gastrointestinal (GI) cancers refer to a group of malignancies associated with the GI tract (GIT). Like other solid tumors, hypoxic regions consistently feature inside the GI tumor microenvironment (TME) and contribute towards metabolic rep...