Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15 [0.03%]
磷酸化蛋白质基因组学揭示RSK信号传导是IL-2或IL-15刺激的自然杀伤细胞增殖所必需的
Melanie A MacMullan,Pin Wang,Nicholas A Graham
Melanie A MacMullan
Natural killer (NK) cells are cytotoxic lymphocytes that play a critical role in the innate immune system. Although cytokine signaling is crucial for the development, expansion, and cytotoxicity of NK cells, the signaling pathways stimulate...
Intestinal fatty acid binding protein (I-FABP) and CXC3L1 evaluation as biomarkers for patients at high-risk for coeliac disease in Johannesburg, South Africa [0.03%]
南非约翰内斯堡高危人群中评估肠脂肪酸结合蛋白(I-FABP)和CXC3L1作为乳糜泻生物标志物的研究
Anastasia Gandini,Tim De Maayer,Cameron Munien et al.
Anastasia Gandini et al.
Coeliac disease (CD) is an autoimmune disorder and one of the few gastroenteropathies with accurate serological testing. CD serology has decreased accuracy for patients on a gluten-free diet and for monitoring mucosal healing. New ancillary...
Associations between interleukin-1-B gene -511G/A polymorphism and sepsis risk: A meta-analysis [0.03%]
白细胞介素1-β基因-511G/Ａ多态性与脓毒症发病风险关联的meta分析
Wenjuan Zheng,Mengyan Chen,Xiaoshui Si
Wenjuan Zheng
The role of the cytokine (IL) gene has been indicated in the progression of sepsis. Nevertheless, the outcomes remain controversial. This meta-analysis aimed to examine the relationship of IL-1B gene -511G/A polymorphism and the risk of sep...
Balancing between apoptosis and survival biomarkers in the patients with tuberculous meningitis [0.03%]
结核性脑膜炎患者凋亡与生存预测标志物的研究
Jayantee Kalita,Ruchi Shukla,Prakash C Pandey et al.
Jayantee Kalita et al.
Background: The balancing factor of apoptosis, survival, inflammatory and oxidative stress biomarkers may determine the clinico-radiological severity and death in the patients with tuberculous meningitis (TBM). ...
Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis [0.03%]
评估血清白细胞介素-28作为预测创伤患者脓毒症死亡率生物标志物的价值
Yang Yang,Jiajun Chen,Chengla Yi et al.
Yang Yang et al.
Background: Serious trauma due to various factors is a major global public issue, and sepsis is a major cause of trauma-associated mortality. Timely diagnosis and suitable treatment of post-traumatic sepsis are crucial to...
Prioritization and Meta-analysis of regulatory SNPs identified IL6, TGFB1, TLR9 and MMP7 as significantly associated with cervical cancer [0.03%]
优先筛选并荟萃分析的调控SNPs中IL6、TGFB1、TLR9和MMP7基因显著与宫颈癌相关
Agneesh Pratim Das,Meenu Chopra,Subhash M Agarwal
Agneesh Pratim Das
Cervical cancer is a leading women cancer globally with respect to both incidence and mortality. Its increased risk has been linked with HPV infection and genetic variations like single nucleotide polymorphisms (SNPs). Although, studies hav...
Meta-Analysis
Cytokine. 2022 Sep:157:155954. DOI:10.1016/j.cyto.2022.155954 2022
LncRNA SNHG6 accelerates hyperoxia-induced lung cell injury via regulating miR-335 to activate KLF5/NF-κB pathway [0.03%]
长链非编码RNA SNHG6通过调节miR-335激活KLF5/NF-κB途径促进hyperoxia诱导的肺细胞损伤
Yan-Ni Meng,Yan-Ping Chen,Min Yang et al.
Yan-Ni Meng et al.
Background: Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants, and its pathogenesis has not been clarified. Long non-coding RNAs (lncRNA) have important functions in cell bioactivity. ...
Polymorphisms in immune-mediator genes and the risk of dengue virus infection: Lights from a systematic revaluation by Bayesian approaches [0.03%]
免疫介导基因多态性与登革病毒感染风险：基于贝叶斯方法的系统评价新视角
Alessandro Luiz Araújo Bentes Leal,Fyama Araújo da Silva,Jae Il Shin et al.
Alessandro Luiz Araújo Bentes Leal et al.
Dengue fever is a clinical manifestation of dengue virus (DENV) infection well defined by the intense host immune response with the development of high fever, anorexia, headache and muscle pain. Several immune mediators are involved in the ...
Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality [0.03%]
干扰素诱导跨膜蛋白3基因rs12252多态性与新冠肺炎死亡率的影响关系
Iraj Ahmadi,Alireza Afifipour,Fatemeh Sakhaee et al.
Iraj Ahmadi et al.
Background and aims: Interferon-induced transmembrane protein 3 (IFITM3) plays a critical role in the adaptive and innate immune response by preventing membrane hemifusion between the host and viral cell cytoplasm. This s...
Leishmania intercepts IFN-γR signaling at multiple levels in macrophages [0.03%]
利什曼原虫从多个层面干扰巨噬细胞中IFN-γR信号转导路径
Dhiraj Gurjar,Sananda Kumar Patra,Neelam Bodhale et al.
Dhiraj Gurjar et al.
IFN-γ, a type 2 interferon and a cytokine, is critical for both innate and adaptive immunity. IFN-γ binds to the IFN-γRs on the cell membrane of macrophages, signals through JAK1-STAT-1 pathway and induces IFN-γ-stimulated genes (ISGs)....