Leishmania donovani infection-driven high levels of IL-10 causes hypoalbuminemia in human visceral leishmaniasis [0.03%]
利什曼原虫感染导致的人类黏膜内脏利什曼病低白蛋白血症及其机制研究
Bharat Singh,Sheetal Saini,Smita Kumari et al.
Bharat Singh et al.
Visceral leishmaniasis, caused by Leishmania donovani is characterized by clinicopathological features like hepatomegaly with loss of liver function, etc. Albumin is an essential parameter of liver function, performing various tasks like ma...
FcRn inhibitors in immune thrombocytopenia: A comprehensive review of therapeutic advances and clinical outcomes [0.03%]
免疫性血小板减少症中FCRn抑制剂治疗的进展及临床疗效综述
Mohammad Ali Nilforoushzadeh,Nazila Heidari,Seyedayin Hosseini et al.
Mohammad Ali Nilforoushzadeh et al.
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts, leading to bleeding risks. Despite existing treatments, many patients with chronic or refractory ITP remain inadequately managed. Fc-receptors, in...
Endoplasmic reticulum stress markers in tularemia: a case-control study [0.03%]
佛朗克氏体感染的内质网应激标志物研究：一项病例对照研究
Yasemin Çakır Kıymaz,Serkan Bolat
Yasemin Çakır Kıymaz
Tularemia is a zoonotic infectious disease caused by Francisella tularensis. It is transmitted by rodents and results in an infectious disease characterized by lymphadenopathy. This study aims to evaluate the role of endoplasmic reticulum (...
Expression of Progranulin and its related mechanism with exosomes from peripheral blood mononuclear cells CD4 + T cells in patients with thyroid-associated ophthalmopathy [0.03%]
甲状腺相关性眼病外周血单核细胞CD4+T细胞源性外泌体中Progranulin的表达及其机制探讨
Lina Wang,Yue Hai,Xueying Zeng et al.
Lina Wang et al.
Background: The expression of serum progranulin (PGRN) and the related immunological mechanisms of peripheral blood mononuclear cells (PBMCs) CD4 + T cells exosomes in thyroid-associated ophthalmopathy (TAO) are currently...
GABA and GABAergic dysfunction in COVID-19: Piecing the puzzle with targeting immunity and several inflammatory pathways [0.03%]
冠状病毒疾病的伽马氨基丁酸和伽马氨基丁酸功能障碍：通过针对免疫和多种炎症途径拼凑难题
Hamza M A Eid,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Hamza M A Eid et al.
Coronavirus disease 2019 (COVID-19) is a global pandemic disease caused by a new type of respiratory virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The primary factors contributing to inflammatory and immunologic...
Elevated CXCL1 expression contributes to the development of pediatric Crohn's disease and serves as a diagnostic marker: A reanalysis based on the integrative bioinformatics [0.03%]
CXCL1高表达参与儿童克罗恩病的发生发展并可作为诊断标志物的生物信息学整合分析研究
Xiaohong Xu,Jie Wu
Xiaohong Xu
Purpose: Pediatric Crohn's disease (PCD), which is a severe illness impacting the physical health of children. Nevertheless, there is still a lack of highly efficient diagnostic markers. Here, we aim to develop efficient ...
A cross-sectional study investigating the underlying inflammatory mechanisms of post-stroke insomnia [0.03%]
横断面研究调查中风后失眠的潜在炎症机制
Lang Zhao,Ting Sun,Ping Tong et al.
Lang Zhao et al.
Background: It is widely postulated that inflammation contributes to the pathogenesis of both stroke and insomnia; and vice versa. However, the mechanism underlying post-stroke insomnia (PSI) remains ambiguous. Therefore,...
Interleukin-enhanced CAR-engineered immune cells in tumor immunotherapy: current insights and future perspectives [0.03%]
肿瘤免疫治疗中IL细胞因子增强的CAR工程化免疫细胞：研究现状与未来展望
Min Wang,Zixuan Wang,Guangji Zhang et al.
Min Wang et al.
Despite the remarkable clinical success of chimeric antigen receptor (CAR)-T cell therapy in hematologic malignancies, the therapeutic efficacy of conventional second-generation CAR-T cells in treating solid tumors remains suboptimal, prima...
Etanercept, a peripherally restricted TNF inhibitor, enhances cocaine-induced locomotor behaviors in male, but not female, rats [0.03%]
外周限制型肿瘤坏死因子抑制剂Etanercept可增强雄性而非雌性大鼠的可卡因诱导的运动行为
Scott D Dunn,Sonita Wiah,Anwar Lami et al.
Scott D Dunn et al.
Cocaine dysregulates tumor necrosis factor (TNF) signaling in mesolimbic substrates, suggesting a role for TNF in cocaine-induced hyperlocomotion, a signature preclinical effect of cocaine. Inhibition of TNF signaling by genetic deletion or...
The role of IL-39 in autoimmune diseases: From general to immunopathogenesis [0.03%]
白细胞介素39在自身免疫疾病中的作用：从一般到免疫病理发生学
Parisa Ahmadi,Atousa Janzadeh,Maryam Honardoost et al.
Parisa Ahmadi et al.
IL-39, a cytokine from the IL-12 family that appears to be produced primarily by B cells, consists of the IL-23p19 and Ebi3 subunits, which signal through IL-23R/gp130 to activate STAT1/STAT3. Some studies suggest elevated IL-39 levels in c...