Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy [0.03%]
探究免疫细胞表型和循环炎症因子在糖尿病神经病变发病机制中的作用
Nuojin Guo,Qijun Li,Hua Wang et al.
Nuojin Guo et al.
Background: Complex interactions of metabolic abnormalities, immune cell activation, and chronic inflammation are considered critical factors in the pathogenesis and progression of diabetic neuropathy (DN). However, the a...
Shared molecular biomarkers and therapeutic targets in rheumatoid arthritis and osteoarthritis: Focus on EIF3B, KHSRP, NCL, PDCD1LG2, and SLC25A37 [0.03%]
类风湿关节炎和骨关节炎中共有的分子生物标志物和治疗靶点：重点关注EIF3B、KHSRP、NCL、PDCD1LG2和SLC25A37
Hui Li,Zhenxue Long,Chengguang Wei et al.
Hui Li et al.
Rheumatoid arthritis (RA) and osteoarthritis (OA) are the most common joint diseases globally, posing major public health challenges. Although they are often distinguished from each other in clinical diagnoses, we hypothesize that RA and OA...
Characterising high-resolution dynamics of inflammatory and SCFA responses to food consumption in healthy men: A pilot biomarker discovery study [0.03%]
健康男性食用食物后的高分辨率动态炎症和SCFA响应特征：一项生物标志物发现研究
C V Hall,L Garnier,M Gencoglu et al.
C V Hall et al.
Understanding inflammatory responses after food consumption and at fasting is crucial for assessing the impact of diet on long-term health. To study these responses meaningfully, biomarkers must be responsive to food intake, consistent acro...
Insulin growth factor 2 contributes to adipose stem cell-derived exosome mediated angiogenesis against hind-limb ischemia injury [0.03%]
成体脂肪干细胞源性外泌体通过携带IGF2促进下肢缺血损伤修复中内皮细胞的增值和迁移作用
Xiang Li,Qiang Chen,Ran Li et al.
Xiang Li et al.
Critical limb ischemia is a severe stage when hypoperfusion occurs in patients with lower extremity arteriosclerotic obliterans. Exosomes have emerged as a key therapeutic agent for lower extremity ischemia. However, how these exosomes take...
Associations of FAAH rs324420 with serum lipid profiles are diversified by a high-carbohydrate diet in healthy Chinese adolescents [0.03%]
FAAH基因rs324420多态性与健康中国青少年血清脂质谱分布关联的饮食修饰效应分析：一项饮食干预研究
Yi Lin Shen,Jia Jing Cai,Jun Tao Ren et al.
Yi Lin Shen et al.
Objectives: The present study is to investigate changes of serum lipid profiles in the healthy Chinese adolescents with different genotypes of rs324420 polymorphism at fatty acid amide hydrolase (FAAH) gene (FAAH) after a...
GDF15 upregulation in Parkinson's disease: Compensatory mechanisms and causal insights [0.03%]
帕金森病中GDF15的上调：补偿机制和因果洞察
Sultan M Alshahrani,Hayder M Al-Kuraishy,Ali K Albuhadily et al.
Sultan M Alshahrani et al.
Parkinson's disease (PD) is a prevalent long-term neurodegenerative condition resulting from the impairment of dopaminergic neurons (DNS) in the substantia nigra (SN). It is closely tied to inflammatory processes and oxidative stress, which...
Role of FGF19 in regulating mitochondrial dynamics and macrophage polarization through FGFR4/AMPKα-p38/MAPK Axis in bleomycin-induced pulmonary fibrosis [0.03%]
FGF19通过FGFR4/AMPKα-p38/MAPK轴调控成纤维细胞中线粒体动态及巨噬细胞极化在巴利昔明诱导的肺纤维化中的作用研究
Yang Li,Hong Zhang,Bing Li et al.
Yang Li et al.
Background: In the bleomycin (BLM)-induced pulmonary fibrosis model, macrophage polarization and mitochondrial dynamic imbalance are critical drivers of fibrogenesis. Although fibroblast growth factor 19 (FGF19) has been ...
Interleukin-18 (IL-18) engineered for half-life extension and resistance to IL-18 binding protein (IL-18BP) to enhance anti-cancer therapeutic potential [0.03%]
用于延长半衰期和抵抗IL-18结合蛋白（IL-18BP）的白细胞介素18（IL-18）增强其抗癌治疗潜力
Kristiana H Dreaden,Su-Ping Pearson,Pinar S Gurel et al.
Kristiana H Dreaden et al.
Recombinant interleukin-18 (IL-18) holds promise as a therapeutic for oncology, as a robust activator of adaptive and innate immune cells and a potent producer of IFN-γ. However, clinical success has been limited due to rapid upregulation ...
Effects of acute heat exposure on monocyte phenotype following exhaustive exercise: An ex vivo study [0.03%]
一次急性热暴露对 exhaustive 运动后单核细胞表型的影响：体外实验研究
Lucas de Lima Schipper,Igor Martins da Silva,Bruna Marmett et al.
Lucas de Lima Schipper et al.
Background/aim: This study aimed to evaluate the effects of ex vivo whole blood heat therapy on monocyte inflammatory response following exhaustive exercise in young individuals. ...
ATM and ATR inhibition increases radiosensitivity and cGAS-STING activation in prostate cancer [0.03%]
ATM和ATR抑制增加前列腺癌的放射敏感性及cGAS-STING活化
Nina van Campen,Vera E Mekers,Maaike W Looman et al.
Nina van Campen et al.
Despite the availability of multiple effective therapies for localized prostate cancer, many patients still progress to incurable metastasized castration resistant prostate cancer (mCRPC). About 23 % of mCRPC patients carry alterations in D...