Epitranscriptomic regulation of immunity: The role of m6A in shaping immune response dynamics [0.03%]
表观转录组学修饰在免疫调控中的作用及m6A甲基化对动态免疫响应的塑造机制研究
Devesh Srivastava,Vinayak Nayak,Srijoni Pahari et al.
Devesh Srivastava et al.
N6-methyladenosine (m6A) is the most prevalent internal modification found in eukaryotic mRNAs and plays a critical role in shaping immune response. It acts as a dynamic regulatory step modulating the splicing, stability, degradation and tr...
Causal association between 91 circulating inflammatory proteins and primary open-angle glaucoma: a bidirectional Mendelian randomization study [0.03%]
91种循环炎症蛋白与原发性开角型青光眼的因果关联：双向孟德尔随机化研究
Changyang Liu,Miao Zhao,Xi Wang et al.
Changyang Liu et al.
Background: Glaucoma, especially primary open-angle glaucoma (POAG), is a leading cause of irreversible vision loss. While elevated intraocular pressure is a major risk factor, the pathogenesis of POAG also involves genet...
Effect of cytokine TGF-β1 on pathological changes in diabetic retinopathy [0.03%]
细胞因子TGF-β1对糖尿病视网膜病变病理改变的影响
Ilona Hartmane,Ingmars Mikazans
Ilona Hartmane
The purpose of the study was to determine the role of the cytokine transforming growth factor beta 1 (TGF-β1) in the progression of diabetic retinopathy and to assess its importance as a potential therapeutic target for slowing down pathol...
Cord blood chemokine levels as a predictor of oxidative stress and morbidities of prematurity [0.03%]
新生儿脐带血趋化因子水平与氧化应激及早产儿并发症的相关性研究
Gozdem Kayki,Erdal Sag,Ferid Aliyev et al.
Gozdem Kayki et al.
Objective: Oxidative stress during the antenatal period causes an increase in the risk of morbidity and mortality in newborns. This study aimed to determine oxidative stress in the antenatal period, by measuring chemokine...
Binyun Liu,Quzong Zhaxi,Zhuoga Danzeng et al.
Binyun Liu et al.
Background: Immunomodulation is integral to the body's adaptation to varying altitudes. Nevertheless, the effects of immune regulation on the onset of high-altitude pulmonary edema (HAPE) are not well understood. This res...
Impact of rotating night shift work on immune homeostasis among hospital employees during the COVID-19 pandemic [0.03%]
新冠肺炎疫情期间轮班制对医院员工免疫稳态的影响
Sheng-Che Lin,Chiou-Feng Lin,Szu-Yuan Wu et al.
Sheng-Che Lin et al.
Background: Night shifts may disrupt circadian rhythms and immunity, potentially leading to health issues such as increased susceptibility to infectious diseases and impaired vaccine responses. This concern is particularl...
Genetic polymorphisms of IFNL3 are associated with risk of immune checkpoint inhibitor-related pneumonitis in lung cancer patients [0.03%]
干扰素λ基因多态性与肺癌患者免疫检查点抑制剂相关肺炎风险的相关性研究
Shengzu Peng,Zhihui Duan,Kai Zhang et al.
Shengzu Peng et al.
Background: Checkpoint inhibitor-related pneumonitis (CIP) is the most common fatal adverse reaction among lung cancer patients received immune checkpoint inhibitors (ICIs) therapy. IFN-λ3 has anti-tumor and immunomodula...
Serum cytokine pattern for the early identification of hemophagocytic lymphohistiocytosis in diffuse large B-cell lymphoma [0.03%]
弥漫性大B细胞淋巴瘤患者继发噬血细胞性淋巴组织细胞增生症的早期血清细胞因子模式探究
Jing Ni,Dongmei Zou,Yaofang Cao et al.
Jing Ni et al.
Hemophagocytic lymphohistiocytosis (HLH) is generally recognized as a rapidly progressive syndrome of excessive immune activation and a cytokine storm. Diffuse large B-cell lymphoma (DLBCL), a prevalent subgroup of non-Hodgkin lymphoma, rep...
Evaluation of the circulating levels of IL-33 in patients with osteoarthritis: role of rs1929992 variants [0.03%]
评估骨关节炎患者循环中IL-33水平的变化：rs1929992多态性的作用
Nahid Alimoradi,Fatemeh Jahankhah,Habibollah Jokardarzi et al.
Nahid Alimoradi et al.
Background: Osteoarthritis (OA) is among the common chronic health conditions which impacts many aspects of an individual's life from physical function to mental health. Inflammation, in the joint as well as system inflam...
Impact of home-based multi-task exercise training on executive function and TNF/IL-10 ratio in postmenopausal women with diabetes [0.03%]
家庭多任务运动训练对绝经后糖尿病女性执行功能和TNF/IL-10比值的影响
A Jamali,M Molanouri Shamsi,M Behmanesh et al.
A Jamali et al.
Diabetes, via chronic metabolic and inflammatory dysregulation, may impair immune function and contribute to cognitive decline, particularly in executive functions. In this study, we examined changes in the cytokines IL-10 and TNF, as well ...