The NLRP3 inflammasome activation boosts lung injury, inflammation, and macrolide resistance in mycoplasma pneumoniae pneumonia [0.03%]
NLRP3炎症小体激活加重支原体肺炎肺损伤、促进炎症和大环内酯耐药形成
Meijun Zhu,Yan Lu,Yan Wei et al.
Meijun Zhu et al.
The increase in the number of macrolide-resistant Mycoplasma pneumoniae (MP) poses a threat to human health worldwide. The present research investigates the role of the NLRP3 inflammasome in mycoplasma pneumoniae pneumonia (MPP). MPP patien...
Aspergillus fumigatus and Mycobacterium tuberculosis synergistically induce TNF and IL-1β via different pathways in human peripheral blood mononuclear cells [0.03%]
烟曲霉和结核杆菌通过不同的途径协同诱导人体外周血单个核细胞产生TNF和IL-1β
Intan M W Dewi,Mariolina Bruno,Nico A F Janssen et al.
Intan M W Dewi et al.
Aspergillus fumigatus may cause infections in individuals with underlying lung damage, such as those with pulmonary tuberculosis (TB). Simultaneous exposure to A. fumigatus and Mycobacterium tuberculosis may worsen lung tissue damage, but t...
Blocking Fpr3 ameliorates osteoarthritis by inhibiting NLRP3-mediated chondrocyte pyroptosis [0.03%]
阻断FPR3通过抑制NLRP3介导的软骨细胞焦亡改善骨关节炎
Bin Zhou,Yaobin Huang
Bin Zhou
Objective: Osteoarthritis (OA) is a chronic joint disorder that frequently diagnosed in elderly individuals. While formyl peptide receptor 3 (Fpr3) is known to play a significant role in inflammation, its involvement in O...
Xi Cao,Jianing Wu,Jing Xie et al.
Xi Cao et al.
CXC motif chemokine ligand 10 (CXCL10), also known as interferon γ-induced protein 10 kDa, is a pleiotropic member of the CXC chemokine family and plays a potent role in cellular functions and pathophysiological processes, which include bu...
Fowl adenovirus serotype 4 ORF1B protein suppresses type I interferon production by inhibiting IRF7 nuclear translocation [0.03%]
番鸭肌尾腺病毒4型ORF1B蛋白通过抑制IRF7核转位抑制I型干扰素产生
Shenyan Gao,Saimin Zhai,Ruixue Li et al.
Shenyan Gao et al.
Fowl adenovirus serotype 4 (FAdV-4), the causative agent of hepatitis-hydropericardium syndrome (HHS), has been reported to counter the host innate immune response. However, the underlying mechanisms employed by FAdV-4 to block cellular ant...
Anti-inflammatory effect of probiotics in patients with Blastocystis spp. infection [0.03%]
布拉酵母菌对伴 blastocystis 血清群感染患者的抗炎作用
Magda S A Abdeltawab,Shimaa M Abdel Aal,Shaimaa Mohammed Ali et al.
Magda S A Abdeltawab et al.
Blastocystis hominis BH infection has been linked to a variety of intestinal immunopathologies. Probiotic therapy is suggested to improve gastrointestinal inflammation during blastocystosis by inducing a pro-inflammatory cytokine response a...
Dysregulation of the leukotriene pathway in Parkinson's disease: The potential role of montelukast [0.03%]
蒙特鲁卡斯在帕金森病白三烯途径失调中的潜在作用
Sultan M Alshahrani,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Sultan M Alshahrani et al.
Leukotrienes (LTs) are inflammatory molecules released from leukocytes and mast cells that induce inflammation by activating leukocyte chemotaxis and vascular permeability. Notably, the LT pathway is implicated in the development and progre...
Circulating miRNAs and inflammatory markers - Associations between miRNAs and cytokine levels point to miRNA-mediated sCD40L release from platelets [0.03%]
循环miRNA和炎症标志物-高水平的miRNA与细胞因子水平相关，并通过miRNA介导的sCD40L释放从血小板中提出观点
Sandra Van der Auwera,Sabine Ameling,Anja Wiechert et al.
Sandra Van der Auwera et al.
MicroRNAs (miRNAs) are gaining increasing attention, particularly because of their involvement in immune-related signaling pathways. We investigated the association between 179 plasma-circulating miRNAs (Plasma Focus microRNA PCR Panel) and...
Manganese transport systems of two enteric bacteria enhance their resistance to stress and enable the bacteria to evade the innate immune responses [0.03%]
两种肠杆菌门细菌的锰转运系统增强其抗逆性并使其能够躲避先天免疫应答
Xiao Wang,Fuhua Zhang,Qianqi Dai et al.
Xiao Wang et al.
Manganese (Mn) is an important element in bacteria-host interactions, exerting significant functions on both bacterial physiology and host immune responses. The importance of bacterial Mn transport systems in mediating bacterial stress resi...
Pro-inflammatory regulation of EGFR-Annexin A2 synergy by sodium butyrate: An upstream target to reduce articular inflammation and cartilage destruction in rheumatoid arthritis [0.03%]
钠丁酸调节促炎症的EGFR-AAXNII协同作用：降低类风湿关节炎滑膜炎症和软骨破坏的上游靶点
Pavan K Jayaswamy,Vikram Haridas,M Vijaykrishnaraj et al.
Pavan K Jayaswamy et al.
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by persistent articular inflammation and joint damage. Our prior research identified a pro-inflammatory interplay between the epidermal growth factor receptor (EGF...