IL-33 links inflammation and bone remodeling in experimental spondyloarthritis and human joint biopsies [0.03%]
IL-33在实验性脊柱关节炎和人类活检标本中的炎症与骨重塑之间的联系
Susana Aideé González-Chávez,Mario Loya-Rivera,Soumya Nair et al.
Susana Aideé González-Chávez et al.
Objective: To investigate the pathogenic role of IL-33 in spondyloarthritis (SpA) by analyzing its expression in both murine and human joint tissues and functionally assessing its impact on fibroblasts. The study evaluate...
Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation [0.03%]
遗传预测的血浆代谢物介导免疫细胞在房颤中的因果作用
Yichao Yu,Korff Krause,Stefan Zarsteck et al.
Yichao Yu et al.
Objective: Determining and measuring the possible mediating function of plasma metabolites in the causative link between immunophenotype and atrial fibrillation (AF). ...
Experimental and computational studies of IL-6 signaling in endothelial cells under hypoxia serum starvation conditions [0.03%]
缺氧和血清饥饿条件下内皮细胞中IL-6信号转导的实验与计算研究
Min Song,Youli Wang,Brian H Annex et al.
Min Song et al.
Many diseases associated with angiogenesis involve inflammatory cytokine mediated responses. Targeting angiogenesis as a predominant strategy has shown limited effects in many contexts including peripheral arterial disease (PAD). One potent...
Delving deeper in the eye of the hurricane: Immunopathogenesis & molecular characterization of cytokine storm in COVID-19, association with disease severity & the therapeutic regimens [0.03%]
深入探究新冠肺炎风暴眼：免疫病理发生及细胞因子风暴的分子特征、与疾病严重程度的关系以及治疗手段
Umaiya Muzaffar,Kamal Shaik Fakiruddin,Yasaman Talebiashtiany et al.
Umaiya Muzaffar et al.
The COVID-19 pandemic elicited by SARS-CoV-2 has led to a world-wide crisis, affecting a substantial percentage of the entire global population, and has engendered profound morbidity and fatalities. SARS-CoV-2 mediates its entry into human ...
Inactivation of LHAVglut2 neurons relieves stress-induced intestine inflammation by sympathetic nerve- intestinal epithelial cell Cxcl1 communication [0.03%]
通过交感神经-肠上皮细胞Cxcl1交流失活LHAVglut2神经元可缓解应激引起的肠道炎症
Keyi Liu,Xinyan Tan,Lianguo Fu et al.
Keyi Liu et al.
Purpose: This study aimed to elucidate the role of lateral hypothalamic area (LHA) Vglut2 neurons in stress-induced intestinal inflammation and to investigate the underlying mechanisms involving neuro-immune interactions....
Genetic evidence for a causal relationship between oral bacterial taxa and asthma in east Asian population [0.03%]
东亚人群口腔细菌与哮喘因果关系的遗传学证据
Wenyan Wei,Zejing Qiu,Lu Xiao et al.
Wenyan Wei et al.
Background: Emerging evidence highlights the significant role of microbiota (lung and gut) in the development of asthma. However, the potential effect between oral microbiota and asthma remains poorly understood. ...
Long non-coding RNA MEG3 rs7158663 polymorphism confers susceptibility to the development of sepsis and is associated with sepsis-induced inflammatory responses [0.03%]
长链非编码RNA MEG3基因多态性与脓毒症易感及相关炎症反应关联研究
Xiemuziya Maimaitirexiati,Minxin Wang,Huijing Zhao
Xiemuziya Maimaitirexiati
Background: The polymorphism of long non-coding RNA (lncRNA) can influence the susceptibility of patients to certain diseases. Objectives: ...
Differential chemokine profiles between lacrimal and salivary glands in a murine model of primary Sjögren disease [0.03%]
实验性原发性干燥综合征模型泪腺和涎腺的细胞因子差异表达分布研究
Ruka Nagao,Kunihiro Otsuka,Shigefumi Matsuzawa et al.
Ruka Nagao et al.
Background: Primary Sjögren disease (pSjD) is an autoimmune disorder that primarily targets the lacrimal glands (LGs) and salivary glands (SGs). However, the differences in immune pathogenesis between LGs and SGs remain ...
Global transcriptomic profiling reveals nicotinamide metabolism as a key regulator of nitric oxide-modulated interferon-γ responses in macrophages [0.03%]
全局转录组分析揭示烟酰胺代谢是调控一氧化氮介导的干扰素γ信号通路的重要途径
Avik Chattopadhyay,Sai Shyam,Shreyasee Das et al.
Avik Chattopadhyay et al.
Interferon-gamma (IFN-γ) is a key regulator of immune responses. A hallmark of IFN-γ responses is inducible nitric oxide (NO), driven primarily by nitric oxide synthase (NOS)2. In this study, we investigated the influence of NO on the IFN...
Serum levels of leucine-rich α-2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4) and furin in pediatric growth hormone deficiency before and after 1-year growth hormone replacement therapy [0.03%]
生长激素缺乏症患儿替代治疗前后血清LRG1、PNT、FABP4和furin水平的改变
Zhibo Zhou,Yuxin Sun,Zeyan Zheng et al.
Zhibo Zhou et al.
Objective: To investigate serum levels of leucine-rich α-2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4), and furin in children with growth hormone deficiency (GHD) compared to idiopa...