Regulation of TREG/TH17 balance by NK cells pretreated with ESTRIOL and bacterial cells in multiple sclerosis [0.03%]
雌三醇联合细菌干预的自然杀伤细胞调节多发性硬化中Treg/Th17平衡的作用机制研究
Irina Nekrasova,Natalia Glebezdina,Irina Maslennikova et al.
Irina Nekrasova et al.
We studied the influence of the pregnancy hormone estriol (E3) and bacterial strains on the ability of NK cells to modulate levels of T regulatory (Treg) and IL-17-producing (Th17) lymphocytes from patients with multiple sclerosis (MS) and ...
Differential cytokine and chemokine signatures in bronchoalveolar lavage and plasma predict clinical outcomes of COVID-19 patients hospitalized in intensive care unit [0.03%]
支气管肺泡灌洗液和血浆中的细胞因子及趋化因子谱可预测重症监护病房中新冠肺炎患者的临床结局
Antonio Piralla,Sabrina Gioria,Giuditta Guerrini et al.
Antonio Piralla et al.
This study explores the immune response dynamics in critically ill SARS-CoV-2 patients compared to non-SARS-CoV-2 controls both hospitalized in intensive care unit (ICU), focusing on localized and systemic inflammatory profiles to identify ...
Role of macrophages reprogramming in pathogenesis of gestational diabetes mellitus [0.03%]
巨噬细胞重编程在妊娠糖尿病发病机制中的作用
K L Milan,R Adhi Shree,N Nandana et al.
K L Milan et al.
Gestational diabetes mellitus (GDM) is a pregnancy-associated condition resulting from glucose intolerance affecting approximately 14 % of pregnant women worldwide and contributing to both maternal and neonatal complications. Macrophages, e...
Cardiotrophin-1 as a predictor of critical COVID-19, mortality, and persistence of pulmonary fibrosis after the acute phase of infection [0.03%]
心肌营养素-1作为预测critical COVID-19、死亡率和急性感染后肺纤维化的持续存在的一项指标
María Íñiguez,Patricia Pérez-Matute,Pablo Villoslada-Blanco et al.
María Íñiguez et al.
Pulmonary fibrosis remains a long-term complication in some COVID-19 recovered patients, particularly in those who suffered from severe disease. Cardiotrophin-1 (CT-1) is an antiapoptotic cytokine related with the progression of fibrotic di...
T1-mapping quantitative assessment of renal function and changes in serum cytokine levels after renal transplantation in children [0.03%]
T1-map定量评估肾移植后儿童肾功能及血清细胞因子变化
XueyingWang,Jun Hu
XueyingWang
Background: Postoperative renal function assessment in pediatric kidney transplant recipients faces the challenge of insufficient sensitivity of traditional indicators. T1-mapping, a non-invasive imaging technique, can qu...
Interferon tau in ruminant reproduction: Mechanisms of maternal recognition of pregnancy and implications for fertility enhancement [0.03%]
反胎蛋白tau在反刍动物生殖中的作用：妊娠识别机制及提高受孕率的含义
Iqra Batool,Rehana Kausar,Muhammad Shahbaz Qamar
Iqra Batool
Low conception rates and early embryonic loss remain major constraints to reproductive efficiency in ruminants, particularly during the peri-implantation period. Maternal recognition of pregnancy (MRP) is largely mediated by interferon tau ...
Neuregulin 4 attenuates osteoarthritis by decreasing macrophage M1 polarization through PI3K/AKT signaling [0.03%]
神经调节素4通过PI3K/Akt信号传导降低M1型巨噬细胞极化从而缓解骨关节炎
Chao Wang,Jinjian Zheng,Chengxin Li et al.
Chao Wang et al.
Altered polarization of synovial macrophages has been identified as a key pathogenic factor in sustaining synovial inflammation and driving osteoarthritis(OA) progression.Neuregulin 4 (Nrg4) is widely involved in inflammatory diseases, such...
The dual role of IL-2 in systemic lupus erythematosus: balancing pro-inflammatory and anti-inflammatory effects [0.03%]
IL-2在系统性红斑狼疮中的双重作用：平衡促炎和抗炎效应
Hao Li,Xiang Lin,Jing He
Hao Li
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by chronic inflammation and immune dysregulation. Interleukin-2 (IL-2), a central cytokine in T-cell biology, plays a paradoxical role in SLE pathogenesis. On ...
Characterizing the mechanisms underpinning interleukin-15Rα-mediated protection against sepsis and candidiasis [0.03%]
白细胞介素-15受体α介导的抗败血症和念珠菌感染的作用机制研究
Jin Yang,Banglao Xu,Ju Cao et al.
Jin Yang et al.
The interleukin (IL)-15Rα receptor has crucial, protective roles in sepsis and candidiasis via binding to its ligand, IL-15. However, the underlying mechanisms remain largely unexplored. In our study, we first confirmed the protective effe...
Rationalized combinatorial targeting of immune co-receptors leads to tumor regression [0.03%]
理性的组合靶向免疫共受体可导致肿瘤消退
Saleha Nisar,Prashant Chauhan,Ashok Patidar et al.
Saleha Nisar et al.
Different co-stimulatory and co-inhibitory molecules influence the dynamicity of an immune response. As their expression levels may collectively decide the amplitude and quality of an anti-tumor immune response, we proposed that the express...