Upregulating lncRNA GUSBP11 protects chondrocytes from IL-1β-induced inflammatory damage via inhibiting miR-122-5p [0.03%]
上调长链非编码RNA GUSBP11通过抑制miR-122-5p保护软骨细胞免受IL-1β诱导的炎症损伤
Zhanqiu Xu,Peigang Guo,Lujun Li et al.
Zhanqiu Xu et al.
Studies have demonstrated that several lncRNAs exhibit abnormal expression levels in patients suffering from osteoarthritis, and in-depth investigation of these aberrantly expressed lncRNAs may pave the way for innovative therapeutic strate...
Effect of basic fibroblast growth factor on hypoxia-inducible factor (HIF)-1α expression (Exp) and HIF-1 transcription in breast Cancer cell through PI-3 K Akt signaling [0.03%]
成纤维细胞生长因子对乳腺癌细胞缺氧诱导因子表达及转录的作用机制研究
Chengcai Zhang,Jinxia Yu,Shuaifeng Li
Chengcai Zhang
Objective: To investigate the effect of basic fibroblast growth factor (bFGF) on hypoxia-inducible factor (HIF)-1α expression (Exp) and HIF-1 transcription in breast cancer (BC) cells. ...
Extracellular HSP70 facilitated β-glucan induced trained immunity in macrophages to suppress sepsis via TLR2-NF-κB axis [0.03%]
细胞外HSP70通过TLR2-NF-κB轴促进β-葡聚糖诱导的训练免疫以抑制脓毒症
Ran Qi,Xin Cheng,Shan Chen et al.
Ran Qi et al.
Sepsis is a common systemic infectious disease followed by extremely high incidence and mortality with no effective treatment and clinical drugs. As a key mediator involved in infection and immunity, it has been reported that sepsis patient...
The diagnostic value and clinical correlations of bone marrow supernatant S100A8 and S100A9 in myelodysplastic neoplasms [0.03%]
骨髓单核细胞S100A8和S100A9的诊断价值及临床意义分析
Xuefeng Li,Qing Li,Xinrong Xiang et al.
Xuefeng Li et al.
Purpose: Myelodysplastic neoplasms (MDS) are heterogeneous neoplasms that originate from bone marrow (BM) hematopoietic stem cells. S100A8 and S100A9 (S100A8/9) are crucial molecules involved in the innate immune pathogen...
Smoking-induced shifts in salivary exosomal cytokines and amino acid profiles as potential early biomarkers for oral cancer [0.03%]
吸烟引起唾液外泌体细胞因子和氨基酸水平的变化可能成为口腔癌的早期生物标志物
Afsareen Bano,Ravina Vats,Pooja Yadav et al.
Afsareen Bano et al.
Background: Chronic smoking is an established risk factor for oral cancer (OC). The role of tobacco in oral squamous cell cancer (OSCC) emphasizes the need for non-invasive diagnostic approaches to identify early molecula...
M2 macrophage-targeting peptide-modified liposomes enhance the uptake and antitumor efficacy of liposomal IFN-γ in mice with C26 colon carcinoma [0.03%]
一种新型载药脂质体在C26结肠癌小鼠模型中的抗肿瘤效应研究
Maryam Kateh Shamshiri,Roghayyeh Vakili-Ghartavol,Hammed Tanimowo Aiyelabegan et al.
Maryam Kateh Shamshiri et al.
While liposomes enhance the safety and pharmacokinetic profile of free drugs, they have not significantly improved therapeutic efficacy. To overcome this challenge, targeted depletion of tumor-associated macrophages (TAMs) shows significant...
Molecular mechanisms of transcription factor KLF4-mediated immune infiltration influencing lung adenocarcinoma invasion [0.03%]
转录因子KLF4介导的免疫浸润影响肺腺癌侵袭的分子机制研究
Kaining Jia,Yiwen Na,Qiang Lin
Kaining Jia
Background: Lung adenocarcinoma (LUAD) is associated with an increasing incidence and mortality rate while existing treatment strategies continue to exhibit considerable limitation. Studies have demonstrated that upregula...
Role of Interleukins-8, -17 and -22 in Iraqi postmenopausal women with Osteoporosis [0.03%]
白细胞介素-8、-17和-22在伊拉克绝经后妇女骨质疏松症中的作用研究
Reem Salim Sultan Al-Lami,Jabbar Hameed Yenzeel Al-Hilfy
Reem Salim Sultan Al-Lami
Objectives: Osteoporosis (OP) is a systemic skeletal disease characterized by low bone mineral density and deterioration of bone architecture, resulting in bone strength reduction and increased fracture susceptibility. Es...
Exploring the mechanism and crosstalk between IL-6 and IL- 1β on M2 macrophages under metabolic stress conditions [0.03%]
探讨代谢压力条件下IL-6和IL-1β作用于M2型巨噬细胞的机制及相互影响
Shawna Yadav,Anusha Prasannan,Kaliyamurthi Venkatachalam et al.
Shawna Yadav et al.
Macrophages are highly variable immune cells that are important in controlling inflammation and maintaining tissue balance. The ability to polarize into two major types-M1, promoting inflammation, and M2, resolving inflammation and contribu...
Exploring the causal relationship between inflammatory cytokines, metabolites, and Behcet's syndrome: Mendelian randomization [0.03%]
炎症细胞因子、代谢物和贝赫切特综合征之间的因果关系：孟德尔随机化研究
Jiaqi Kong,Xinpeng Liu,Huishu Li et al.
Jiaqi Kong et al.
Introduction: Behcet's syndrome, as a vasculitic disease involving multiple systems, often induces oral mucosal ulcers. However, levels of inflammatory cytokines and metabolites are unknown for the probability of developi...