A systematic review and meta-analysis of the association between endothelial nitric oxide synthase (eNOS) rs2070744 polymorphism and preeclampsia [0.03%]
内皮型一氧化氮合酶(eNOS)基因多态性与子痫前期关联的系统评价和 Meta 分析
Md Shafiul Hossen,Md Abdul Aziz,Md Abdul Barek et al.
Md Shafiul Hossen et al.
Objective: Preeclampsia, characterized by hypertension and proteinuria, is a medical condition associated with maternal and fetal morbidity and mortality. Previous studies reported conflicting correlations between the eNO...
Effect of Saccharomyces cerevisiae β-glucan on the T helper cytokine profile [0.03%]
酿酒酵母β-葡聚糖对T辅助型细胞因子谱的影响
Patricia Vuscan,Rutger J Röring,Brenda Kischkel et al.
Patricia Vuscan et al.
ABBi16 is a high-complexity blend of β-1,3/1,6-glucans from Saccharomyces cerevisiae with strong immunomodulatory activities, that have been recently shown to support anti-tumoral immune responses through the induction of trained immunity....
Immune checkpoint inhibitors mediate myocarditis by promoting macrophage polarization via cGAS/STING pathway [0.03%]
免疫检查点抑制剂通过cGAS/STING途径促进巨噬细胞极化从而导致心肌炎
Zhenzhu Cao,Yu Zhang,Huihui Jia et al.
Zhenzhu Cao et al.
Background: Immune checkpoint inhibitors has opened up new avenues for cancer treatment, but serious cardiac injury has emerged in their use. A large number of data have shown that abnormal activation of cytosolic DNA-sen...
Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways [0.03%]
山柰酚和尼可地尔对完全弗氏佐剂诱导的大鼠类风湿关节炎的作用及TLR4/NF-κB诱导的细胞焦亡、Nrf-2/HO-1和OPG/RANKL通路的新兴作用机制研究
Asmaa H Okasha,Islam Ibrahim Hegab,Monira A Seleem et al.
Asmaa H Okasha et al.
Aim and background: Our study explored the novel mechanisms implicated in the anti-rheumatic potential of fisetin and/or nicorandil (NIC) intervention. Me...
Immune mechanisms in multiple sclerosis: CD3 levels on CD28+ CD4+ T cells link antibody responses to human herpesvirus 6 [0.03%]
多发性硬化症的免疫机制：CD4+CD28+T细胞中CD3水平与人类疱疹病毒6抗体反应的相关性
Liang Cao,Chen Chen,Wenjun Pi et al.
Liang Cao et al.
Compelling evidence suggests a significant association between antibody-mediated immune responses and multiple sclerosis (MS). However, the exact causal relationships between these immune responses and MS remain unclear. In this study, we c...
TLR3 as an emerging molecule facilitating pyroptosis in the context of rheumatoid arthritis: A study combined bioinformatics and experimental validation [0.03%]
TLR3在类风湿关节炎促细胞焦亡中的作用及机制研究：生物信息学和实验验证相结合的方法
Meng-Yuan Zhou,Hong-Yan Feng,Tian-Tian Wang et al.
Meng-Yuan Zhou et al.
Background: Rheumatoid arthritis (RA) is an inflammatory disease of the joints mediated by immune cells. As an immune-related mode of cell death, pyroptosis has yet to be fully understood in RA. This research identified n...
Knockout or treatment with an antagonist of formyl peptide receptor 1 protects mice from sepsis by inhibiting inflammation [0.03%]
敲除或用肽受体1拮抗剂处理可通过抑制炎症保护小鼠免于患败血症
Gang Ma,Jie Ma,Baofu Qu et al.
Gang Ma et al.
Background: Sepsis is an infection-related systemic inflammation with high mortality rates. Activation of formyl peptide receptor 1 (FPR1) in immune cells can promote their chemotaxis and inflammatory response, which imba...
Transforming growth factor beta induces interleukin-11 expression in osteoarthritis [0.03%]
转化生长因子β诱导骨关节炎中的白介素-11表达
Juliane Lokau,Miriam Bollmann,Yvonne Garbers et al.
Juliane Lokau et al.
Interleukin-11 (IL-11) is a member of the IL-6 family of cytokines and possesses both pro- and anti-inflammatory properties. IL-11 activates its target cells via binding to a membrane-bound IL-11R and subsequent formation of a homodimer of ...
Prognostic significance of cytokine dysregulation in critically ill COVID-19 patients [0.03%]
细胞因子紊乱在重症COVID-19患者中的预后意义
Fabian Fellipe Bueno Lemos,Luana Weber Lopes,Gabriel Carvalho Brito et al.
Fabian Fellipe Bueno Lemos et al.
Background: Understanding the immunopathogenesis of COVID-19 has yielded valuable insights into predicting adverse outcomes-particularly mortality. However, significant gaps persist in our comprehension of the complex int...
Association between clinical activity score and serum sPD-1 and sPD-L1 levels during systemic glucocorticoid treatment for active moderate-to-severe thyroid eye disease [0.03%]
活动性中重度甲状腺相关性眼病系统性糖皮质激素治疗过程中临床活动评分与血清sPD-1和sPD-L1水平的相关性研究
Katarzyna Cieplińska,Emilia Niedziela,Agata Kopacz Rdzanek et al.
Katarzyna Cieplińska et al.
Background: CD4+ T lymphocytes are key immune cells involved in orbital inflammation in thyroid eye disease (TED). Inhibition of their activity is important in treatment of TED, but effective drugs targeting these cells a...