Evaluating the evidence for GM-CSF as a host-directed therapy in respiratory infections [0.03%]
评估GM-CSF作为宿主导向疗法在呼吸系统感染中的证据
Camille David,Charles Verney,Mustapha Si-Tahar et al.
Camille David et al.
Novel therapeutic approaches are needed to treat respiratory infections due to the rising antimicrobial resistance and the lack of effective antiviral therapies. A promising avenue to overcome treatment failure is to develop strategies that...
Microglial pyroptosis induced by SENP7 via the cGAS/STING/IRF3 pathway contributes to neuronal apoptosis [0.03%]
SENP7通过cGAS/STING/IRF3通路诱导的小胶质细胞焦亡促进神经元凋亡
Lin Liu,Fei Xiao,Jinyue Yang et al.
Lin Liu et al.
Background: Maternal anesthetic exposure may exacerbate significant neurocognitive risks in the immature brains of fetuses. However, the mechanisms through which sevoflurane exposure during pregnancy results in cognitive ...
Seasonal variation in the associations between self-reported long-COVID symptoms and IL-6 signalling-related factors (particularly the rs2228145 variant of the IL-6R gene): A clinical study [0.03%]
自我报告的长期新冠症状与IL-6信号相关因素（特别是IL-6R基因的rs2228145变异）之间关联的季节变化：一项临床研究
Katie Rees,Rebecca Aicheler,Lee Butcher et al.
Katie Rees et al.
This observational study focused on the impact of Interleukin-6 (IL-6)-related factors (notably the IL-6 receptor (IL-6R) gene's rs2228145 polymorphism) on long-COVID risk in individuals who had previously experienced COVID-19 infection(s)....
Circulating inflammatory cytokines and risk of aortic stenosis: A Mendelian randomization analysis [0.03%]
循环的炎性细胞因子与主动脉瓣狭窄的风险：一项孟德尔随机化分析
Xiaohan Qiu,Jijun Wu,Zehao Chen et al.
Xiaohan Qiu et al.
Background: Observational studies have consistently reported positive associations between inflammatory biomarkers and the risk of developing aortic stenosis (AS). However, it is crucial to acknowledge that conventional o...
LINC-PINT suppresses the progression of acute myeloid leukemia via miR-767-5p/SUZ12-mediated JAK/STAT signaling pathway [0.03%]
LINC-PINT通过miR-767-5p/SUZ12介导的JAK/STAT信号通路抑制急性髓系白血病的进展
Lei Xiang,Xue Lin,Yong Wu
Lei Xiang
Background: Long noncoding RNA (lncRNA) long intergenic non-protein-coding RNA, p53-induced transcript (LINC-PINT) has shown a crucial role in cancer cells. However, its function in acute myeloid leukemia (AML) is unclear...
Seyed Mohsen Aghaei-Zarch,Leila Mahmoudieh,Mohammad Miryounesi et al.
Seyed Mohsen Aghaei-Zarch et al.
Background: Diabetic nephropathy (DN) is a significant driver of end-stage renal disease, requiring kidney replacement therapies such as transplantation and dialysis. Given the critical importance of understanding the ons...
The intricate ballet of inflammation and autophagy: Insights from Mycoplasma gallisepticum-infected HD11 cells [0.03%]
炎症和自噬的复杂相互作用：HD11细胞中解脲支原体感染带来的启示
Yuquan Guo,Wanying Hu,Jiaqi Hu et al.
Yuquan Guo et al.
Objectives: Mycoplasma gallisepticum (M. gallisepticum) infection often leads to inflammatory damage and immunosuppression. Macrophages play a crucial role as the primary immune defense in chickens, with their inflammator...
Molecular study and determining the levels of some interleukins in children with Entamoeba histolytica [0.03%]
儿童溶组织内阿米巴中某些细胞因子分子水平的测定研究
Ayser I Abdul-Aziz
Ayser I Abdul-Aziz
The processes by which amebiasis causes host mucosal inflammation are not entirely understood. In order to identify Entamoeba histolytica molecularly and measure the amounts of certain interleukins in children who were infected, this study ...
Interleukin-4 ameliorates macrophage lipid stress through promoting cholesterol efflux and lipid homeostasis [0.03%]
白细胞介素4通过促进胆固醇外流和脂质稳态来改善巨噬细胞的脂质应激
Kuo-Ting Ho,Fang-Yeh Chu,Yi-Kai Lin et al.
Kuo-Ting Ho et al.
Over-nutrition and lipid metabolic abnormalities are correlated with obesity and type 2 diabetes mellitus (T2DM). Individuals with long-term hyperglycemia and dyslipidemia are susceptible to life-threatening complications such as atheroscle...
A pilot investigation on inflammatory markers and theta burst stimulation protocol interaction along a three-month recovery course following an isolated upper limb fracture [0.03%]
孤立上肢骨折后三个月恢复过程中炎症标志物与theta 爆发刺激方案相互作用的初步研究
Bénédicte Robitaille,Alberto Herrero Babiloni,Marianne Jodoin et al.
Bénédicte Robitaille et al.
This study investigates the effects of theta burst stimulation (TBS) on inflammatory markers in patients with isolated upper limb fractures (IULF). Participants underwent a 10-day TBS intervention following a randomized matched pair design....