Exosome-mediated communication between T cells and dendritic cells: Implications for therapeutic strategies [0.03%]
T细胞和树突状细胞之间通过外泌体进行的交流：对治疗策略的影响
Tahereh Kashkoulinejad Kouhi
Tahereh Kashkoulinejad Kouhi
Cell communication is crucial for coordinating physiological functions in multicellular organisms, with exosomes playing a significant role. Exosomes mediate intercellular communication by transporting proteins, lipids, and nucleic acids be...
Fluoxetine mitigates hypothermia and inflammatory responses in lipopolysaccharide-induced systemic inflammation: Insights into serotonergic and hypothalamic thermoregulatory mechanisms [0.03%]
氟西汀减轻脂多糖诱导的系统性炎症中的低体温和炎症反应：血清素能和下丘脑体温调节机制的见解
Isis P Trajano,Luis Henrique Angenendt Costa,Patrícia Passaglia et al.
Isis P Trajano et al.
An abnormally elevated mortality rate is evident in cases of sepsis. To study specific mechanisms of sepsis experimentally, lipopolysaccharide (LPS) systemically administered has been used as a model, in which an exaggerated immune response...
Association between serum levels of inflammatory mediators and periodontitis severity in people with down syndrome [0.03%]
具有唐氏综合症人血清炎症介质水平与牙周炎严重程度的关联性研究
Katia M M Veloso,Monique M M Mouchrek,Joana A B de Sousa et al.
Katia M M Veloso et al.
Evidence suggests that individuals with Down syndrome (DS) have a high prevalence of periodontal disease (PD). Factors such as muscular hypotonia, macroglossia, intellectual deficits, and reduced motor coordination, often combined with inad...
The role of VEGF in Cancer angiogenesis and tumorigenesis: Insights for anti-VEGF therapy [0.03%]
VEGF在癌症血管生成和肿瘤发生中的作用：针对抗VEGF治疗的见解
Zijun Shi,Mengmeng Kuai,Baohua Li et al.
Zijun Shi et al.
Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis, playing a pivotal role in both physiological and pathological processes. It promotes the formation of new blood vessels and activates downstream signaling pa...
The restoration of immunity characterized by the recovery of myeloid dendritic cells represent a favorable response to methylprednisolone therapy for HBV-ACLF patients: A prospective cohort study [0.03%]
以髓样树突状细胞恢复为特征的免疫重建代表了甲基强的松龙治疗HBV-ACLF患者的良好反应：前瞻性队列研究
Lin Jia,Wei-Ping He,Hui-Chun Xing et al.
Lin Jia et al.
Background: The use of methylprednisolone (MP) is still controversial for hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF). We aimed to explore the change in dendritic cells (DCs) during MP treatment in...
Cationic liposomes encapsulating IL-2 selectively induce apoptosis and significantly reduce the secretion of cytokines on M1-murine polarized macrophages [0.03%]
封装IL-2的阳离子脂质体选择性诱导凋亡并显著减少M1小鼠极化巨噬细胞中细胞因子的分泌
C A Vargas-Ángeles,L Trujillo-Cirilo,E Sierra-Mondragón et al.
C A Vargas-Ángeles et al.
Inflammatory diseases pose a global challenge due to the critical role of macrophages in their pathogenesis. This study evaluated the effects of cationic liposomes encapsulating IL-2 (LIP-IL-2) on murine peritoneal macrophages (MP) polarize...
Cytokine atlas of the population-based cohort SHIP-TREND-0 - Associations with age, sex, and BMI [0.03%]
基于人群队列SHRIP-TREND-0的细胞因子图谱 - 与年龄、性别和BMI的关联
Sabine Ameling,Sandra Van der Auwera,Silva Holtfreter et al.
Sabine Ameling et al.
Background: The characterization of physiological immune signatures in a population-based cohort is a prerequisite for identifying pathological immune signatures associated with inflammatory or autoimmune diseases. ...
SAA1 as a key mediator of immune inflammatory pathways in fungal keratitis through FOXO3a phosphorylation regulation [0.03%]
通过FOXO3a磷酸化调节将SAA1作为真菌性角膜炎免疫炎症途径的关键介质
Yihe Liu,Jing Hong,Rongmei Peng
Yihe Liu
Objective: Fungal keratitis (FK) is a severe ocular infection, with its underlying molecular mechanisms remaining incompletely understood. This study aimed to identify and investigate key genes involved in immune-inflamma...
Sahar Safaei,AmirHossein Yari,Omid Pourbagherian et al.
Sahar Safaei et al.
As essential immune system regulators, cytokines are essential for modulating both innate and adaptive immunological responses. They have become important tools in cancer immunotherapy, improving the immune system's capacity to identify and...
Zuzanna Iwanczyk,Hidetaka Hara,David K C Cooper et al.
Zuzanna Iwanczyk et al.
The inflammatory cytokine interleukin 6 (IL-6) plays a role in both acute and chronic organ allotransplant rejection. Data suggest that IL-6 inhibition may help prevent or reverse rejection, with large multi-center trials now underway. Howe...