Exploring the genetic association between inflammatory cytokines and primary ovarian insufficiency: A Mendelian randomization study [0.03%]
炎症细胞因子与卵巢早衰遗传关联的孟德尔随机化研究
Jie Wu,Yancheng Fu,Zhengqi Qiu
Jie Wu
Purpose: This study aims to investigate the genetic underpinnings of Primary Ovarian Insufficiency (POI) by examining the association between 91 inflammatory cytokines identified through genome-wide association studies (G...
Effects of botulinum toxin type a on nucleotide binding oligomerization domain-like receptor 3 inflammasome in trigeminal ganglion of a rat migraine model [0.03%]
A型肉毒毒素对偏头痛模型三叉神经节NLRP3炎性小体的影响研究
Jun Shen,Xiaofeng Zhu,Lei Xia et al.
Jun Shen et al.
Background: Botulinum toxin type A (BTX-A) has been used in the prevention and treatment of chronic migraine, but the detailed mechanism was not clear completely. ...
Chuze Xu,Sohaib Hasan Abdullah Ezzi,Xiaodi Zou et al.
Chuze Xu et al.
Tumor necrosis factor (TNF) is identified as a pro-inflammatory cytokine critical to the pathology of liver disease. In the carbohydrate metabolism, TNF has been demonstrated to impede the insulin signaling pathway, thereby precipitating gl...
Chuanfei Zeng,Fengyuan Niu,Huan Li et al.
Chuanfei Zeng et al.
Liver metastasis can occur in a wide range of cancers and have a significant impact on patient survival and prognosis. Once liver metastasis occurs, patients often lose the opportunity for surgery, and although a small percentage of patient...
Endothelial barrier disruptive effect of IFN-Ƴ and TNF-α: Synergism of pro-inflammatory cytokines [0.03%]
干扰素-GetY和肿瘤坏死因子-α对内皮屏障的破坏作用：促炎细胞因子的协同作用
Chin Theng Ng,Lai Yen Fong,Jun Jie Tan et al.
Chin Theng Ng et al.
Crosstalk and synergy between interferon-γ (IFN-Ƴ) and tumor necrosis factor-α (TNF-α) in endothelial cells have previously been documented, however, there is an absence of articles reviewing the synergistic effect of IFN-Ƴ and TNF-α ...
Tumor-educated Neutrophils Induce Epithelial-mesenchymal Transition and Metastasis in Colorectal Cancer Through Interleukin-17a Secretion [0.03%]
肿瘤教育的中性粒细胞通过分泌白细胞介素17a诱导结直肠癌的上皮间充质转化和转移
Yibing Gong,Qingshuang Luo,Haiqi Tan et al.
Yibing Gong et al.
The role of neutrophils in defending against infections and regulating immune responses is well-known. In cancer, tumor-associated neutrophils also play a significant role in the progression of tumors. However, the specific mechanisms of th...
LTK deficiency induces macrophage M2 polarization and ameliorates Sjogren's syndrome by reducing chemokine CXCL13 [0.03%]
LTK的缺乏通过降低chemokine CXCL13诱导巨噬细胞M2极化并改善干燥综合症
Xiuyuan Feng,Junhui Lu,Wei Cheng et al.
Xiuyuan Feng et al.
Background: Sjogren's syndrome (SS) is an autoimmune disease involving macrophage infiltration of the exocrine glands. LTK, a receptor tyrosine kinase, is involved in many autoimmune diseases, such as lupus erythematosus....
Self-assembling sequentially administered tumor targeted Split IL-12p35 and p40 subunits to improve the therapeutic index of systemically delivered IL-12 therapy for cancer [0.03%]
自组装顺序给药的肿瘤靶向分裂IL-12p35和p40亚基，以提高系统性递送IL-12治疗癌症的治疗指数
P S Gurel,R G Newman,S Pearson et al.
P S Gurel et al.
IL-12, also called IL-12p70, is a highly potent, proinflammatory heterodimeric cytokine that can mediate many beneficial anti-tumor effects. In preclinical studies, recombinant IL-12, as well as IL-12 gene therapies, have demonstrated notab...
Exosomes derived from myelodysplastic syndromes cells induce IL-1β production from macrophages to promote disease progress [0.03%]
来源于骨髓增生异常综合症细胞的外泌体通过诱导巨噬细胞产生IL-1β来促进疾病进展
Peichun Li,Dongmei Guan,Shuo Li et al.
Peichun Li et al.
Background: Exosomes are extracellular vesicles with a membrane structure that play important roles in intercellular communication, material transport and cellular immunity.Our previous study found that exosomes can affec...
Aqueous humor mediator levels as biomarkers of anti-VEGF response in age-related macular degeneration [0.03%]
年龄相关性黄斑变性中抗VEGF反应的玻璃体介质水平生物标志物研究
Stéphanie Baillif,Sacha Nahon-Esteve,Tanguy Pace-Loscos et al.
Stéphanie Baillif et al.
Purpose: To monitor intraocular mediator dynamics in treatment-naïve neovascular age-related macular degeneration (nAMD) patients treated with anti-VEGF intravitreal injections (IVIs) to identify individual mediator patt...