From genes to clinic: Genomic and cross-sectional cohort analysis of oxidative stressors and lipid metabolism in European ancestry [0.03%]
从基因到临床：欧洲血统队列的氧化应激和脂质代谢的基因组学及横断面分析
Bo He,Yingjie Li,Ning Zhou
Bo He
Background: The link between oxidative stress and lipid metabolism is widely studied, but their causal relationship in the general population remains unclear. ...
LINC00426 promotes the progression of atherosclerosis by regulating miR-873-5p/SRRM2 axis [0.03%]
长链非编码RNA LINC00426通过调控miR-873-5p/SRRM2轴促进动脉粥样硬化进展
Bo Zhou,Lu Gan,Pimo Zhou et al.
Bo Zhou et al.
Background: Atherosclerosis (AS) is a disease that occurs in the great arteries and is the main cause of cardiovascular disease and death. Objective: ...
Nicotinamide metabolism affects the prognosis of hepatocellular carcinoma by influencing the tumor microenvironment [0.03%]
烟酰胺代谢通过影响肿瘤微环境而影响肝细胞癌的预后
Min Zhou,Wenhui Zhao,Xiaobo Zhang et al.
Min Zhou et al.
In this study, we utilized the public database along with single-cell genomics techniques to systematically analyze the expression patterns and clinical significance of key genes in the nicotinamide metabolism pathway in liver cancer sample...
ADAM17/ACE2 interaction mediates cadmium-induced brain damage and neuroinflammation in Wistar rats [0.03%]
ADAM17/ACE2相互作用介导的大鼠脑镉损伤及神经炎症反应
Ahmed A Morsi,Ezat A Mersal,Marwa Omar Abdel All et al.
Ahmed A Morsi et al.
Angiotensin-converting enzyme 2 (ACE2) is a critical component in the renin-angiotensin system. A Disintegrin And Metalloprotease 17 (ADAM17) is the first identified sheddase for common inflammatory cytokines. Changes in ACE2 expression and...
A thorough analysis of data on the correlation between IL-16 polymorphisms and the susceptibility to knee osteoarthritis: A meta-analysis [0.03%]
一项关于IL-16多态性与膝骨关节炎易感性相关性的meta分析
Amirhossein Omidi,Mohammad Bahrami,Seyed Alireza Dastgheib et al.
Amirhossein Omidi et al.
Background: Knee osteoarthritis (KOA) is a multifactorial condition affected by genetic and environmental factors. Studies have explored the relationship between IL-16 genetic polymorphisms and KOA risk, but findings have...
Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1 [0.03%]
白藜芦醇通过激活TET1干扰宫颈癌Wnt/β-catenin信号通路
Ji Ren,Luhong Xie,Xiaoyu Zhu et al.
Ji Ren et al.
Epigenetic modification can be a key weapon employed by both sides of the battle between Cervical Cancer progression due to persistent high-risk papillomavirus (hr-HPV) infection and the development of anti-cancer modalities. Alongside the ...
Hydrogen combined with needle-embedding therapy alleviates traumatic brain injury by inhibiting NLRP3 inflammasome activation via STING signaling pathway [0.03%]
氢气联合针刺通过STING信号通路抑制NLRP3炎性小体活化治疗颅脑损伤
Fan Wu,Wenting Su,Xin Wang et al.
Fan Wu et al.
Background: Traumatic brain injury (TBI) is a primary cause of disability and death worldwide and with unmet effective therapies. Molecular hydrogen (H2) exerts latent therapeutic means for TBI. Nevertheless, few studies ...
Novel genetic associations with childhood adipocytokines in Indian adolescents [0.03%]
印度青少年儿童脂联素的新型基因关联性研究
Janaki M Nair,Ganesh Chauhan,Gauri Prasad et al.
Janaki M Nair et al.
Adipocytokines, including leptin, adiponectin, and resistin, are key mediators linking adiposity, insulin resistance, and inflammation. We present the first genome-wide association study (GWAS; N = 5258) and exome-wide association study (Ex...
The synergistic effects of prostaglandin and IL-1β on myometrial and cervical stromal cells at the onset of labor [0.03%]
前列腺素和IL-1β协同作用对分娩发动时期子宫肌层和宫颈间质细胞的影响
Qian Huang,Pin Li,Zheng Zheng et al.
Qian Huang et al.
Inflammatory cytokines such as IL-1β and prostaglandins (PGs) are pivotal in the initiation of labor. Nevertheless, the synergistic interaction between PGs and IL-1β remains to be fully elucidated. Labor is defined as regular and graduall...
Shedding new light on BACE1-mediated modulation of IL-6 signaling: Implications for neural activity and synaptic plasticity in mice [0.03%]
APP加工酶BACE1通过调节IL-6信号通路参与小鼠神经活动和突触可塑性调控的新机制研究
Buket Ucar Franke,Kai Kummer,Stefan Rose-John et al.
Buket Ucar Franke et al.
The pleiotropic cytokine IL-6 regulates numerous processes in the body, including neuronal functions. IL-6 either binds to membrane-bound receptor (mIL-6R) and triggers signaling via heteromerization with the signal transducer gp130 (classi...