Based on the IL-33/ST2-MyD88 signaling pathway to explore the mechanism of aerobic exercise in antagonizing the inflammatory response in depressive mice [0.03%]
基于IL-33/ST2-MyD88信号通路探讨有氧运动拮抗抑郁小鼠炎症反应的机制研究
Lei Gao,Ruilian Liu,He Qu et al.
Lei Gao et al.
Purpose: This study examined how aerobic exercise affect the IL-33/ST2-MyD88 signaling pathway in mice with chronic unpredictable mild stress (CUMS) induced depression METHOD: Thirty-six C57BL/6 mice were randomly assigne...
Pouya Goleij,Alireza Amini,Mohammad Amin Khazeei Tabari et al.
Pouya Goleij et al.
Parkinson's disease (PD) is a neurodegenerative disorder, which primarily impacts the nervous system, marked by its immune and inflammatory characteristics. The interleukin-2 (IL-2) cytokine family has a crucial role in regulating both neur...
Unraveling the immune activation mechanisms of DAMPs in coronary artery disease through transcriptomic and single-cell analyses [0.03%]
通过转录组和单细胞分析解开冠状动脉疾病中DAMPs免疫激活机制
Yinghao Li,Henghe Shi,Yifei Zou et al.
Yinghao Li et al.
This study employs transcriptomics and single-cell analysis to delve into the mechanisms by which damage-associated molecular patterns (DAMPs) trigger immune activation in coronary artery disease (CAD). We obtained RNA-seq data from the GSE...
Augmented hippocampal up-regulation of immune modulators following a peripheral immune challenge in a hemizygous mouse model of the 15q13.3 microdeletion [0.03%]
15号染色体13.3区缺失半合子小鼠模型外周免疫刺激后海马免疫调节剂的上调表达
Katherine A Rees,Kristin M McCamy,Conner I Danao et al.
Katherine A Rees et al.
The strongest known genetic risk factor for generalized epilepsy is the human hemizygous 15q13.3 microdeletion (MD). This 1.5 Mb MD encompasses six genes, including CHRNA7 encoding the alpha7 subunit that forms the homo-pentameric nicotinic...
IL-4 exerts beneficial anti-tumor effect dependent on a short-range manner [0.03%]
IL-4依赖短距离方式产生抗肿瘤效应
J D Zhang,X Y Xue,Y F Zhang et al.
J D Zhang et al.
Anti-inflammatory effects of apigenin on LPS-induced mastitis in lactating SD rats through inhibiting TLR4/NF-κB signaling pathway [0.03%]
黄酮类化合物芹菜素通过抑制 toll 样受体 4/核因子 κb 信号通路发挥抗炎作用并缓解脂多糖诱导的断乳大鼠乳腺炎
Yihan Hu,Yingying Xie,Yiming Sun et al.
Yihan Hu et al.
Mastitis is an important disease of the mammary gland in all kinds of lactating mammals, endangering the development of animal husbandry and human health. Apigenin is one chemical constituent of Taraxacum and Philippine Violet Herb which ar...
Sheela Ramanathan,Antonio Carlos Rosário Vallinoto
Sheela Ramanathan
Editorial
Cytokine. 2025 Apr 23:156940. DOI:10.1016/j.cyto.2025.156940 2025
The mechanism of action of GLUT1 in promoting NETs-mediated impairment of macrophage phenotypic switching based on macrophage-fibroblast interplay [0.03%]
基于巨噬细胞-成纤维细胞互作的GLUT1促进NETs介导的巨噬细胞表型转化障碍的作用机制研究
Wenqiang Li,Shijie Li,Weijing Sun et al.
Wenqiang Li et al.
This study explored the mechanism by which glucose transporter type 1 (GLUT1) promotes neutrophil extracellular trap (NET)-mediated macrophage phenotype conversion in a high-glucose environment, based on the interaction between fibroblasts ...
Downregulation of GFPT2 enhances cisplatin chemotherapy sensitivity in STK11/KRAS mutant non-small cell lung cancer by regulating the hexosamine biosynthesis pathway, resisting tumor growth [0.03%]
GFPT2下调通过调节己糖胺生物合成途径增强STK11/KRAS突变非小细胞肺癌顺铂化疗敏感性并抑制肿瘤生长
Cheng Zhang,Xuelei Yin,Jun Jiang et al.
Cheng Zhang et al.
Objective: To explore the role of GFPT2 in the sensitivity of STK11/KRAS lung cancer cells to cisplatin chemotherapy, and its underlying mechanism. Materi...
Genetic insights into neuroblastoma: the role of immune cell features [0.03%]
遗传学视角下的神经母细胞瘤研究：免疫细胞特征的作用
Yunfei Ma,Qiang He,Yan Su et al.
Yunfei Ma et al.
Objective: To elucidate the causal relationship between immune cells and neuroblastoma, we conducted a two-sample Mendelian randomization (MR) analysis. M...