Longitudinal in vivo evaluation of retinal ganglion cell complex layer and dendrites in mice with experimental autoimmune encephalomyelitis [0.03%]
实验性自身免疫性脑脊髓炎小鼠视网膜神经节细胞复合层和树突的纵向体内评价
Zhen Qian,Ke Zheng,Yanxuan Xu et al.
Zhen Qian et al.
Experimental autoimmune encephalomyelitis (EAE), induced by the immunization of myelin oligodendrocyte glycoprotein (MOG), is related to human MOG antibody-associated disease (MOGAD). Neuroinflammation and demyelination of the optic nerve c...
2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell [0.03%]
二维还是不二维？角膜巩膜组织胶原纤维倾向的深入映射
Fengting Ji,Marissa Quinn,Yi Hua et al.
Fengting Ji et al.
The collagen fibers of the corneoscleral shell play a central role in the eye mechanical behavior. Although it is well-known that these fibers form a complex three-dimensional interwoven structure, biomechanical and microstructural studies ...
Hsin-Yuan Tan,Yueh-Feng Wu,Chia-Yi Wang et al.
Hsin-Yuan Tan et al.
Mechanical signaling plays a crucial role in maintaining extracellular matrix (ECM) homeostasis in various structures. In this study, we investigated the responses of corneal fibroblasts to cyclic stretching loads using an in vitro cell cul...
Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice [0.03%]
SENP1抑制诱导的RUNX1异常SUMO2/3修饰与糖尿病小鼠视网膜病变发生发展密切相关
Wei Zhang,Feng Li,Jiahui Hou et al.
Wei Zhang et al.
Our previous report established that RUNX family transcription factor 1 (RUNX1) promotes proliferation of mouse retinal microvascular endothelial cells (mRMECs) and exacerbates diabetic retinopathy (DR). However, the mechanism behind the up...
Topical Nerve Growth Factor (NGF) restores electrophysiological alterations in the Ins2Akita mouse model of diabetic retinopathy [0.03%]
topical nerve生长因子(NGF)可修复糖尿病视网膜病变胰岛素耐受性小鼠模型的电生理改变
Valerio Castoldi,Gianpaolo Zerbini,Silvia Maestroni et al.
Valerio Castoldi et al.
People suffering from diabetes mellitus commonly have to face diabetic retinopathy (DR), an eye disease characterized by early retinal neurodegeneration and microvascular damage, progressively leading to sight loss. The Ins2Akita (Akita) di...
Corneal epithelium models for safety assessment in drug development: Present and future directions [0.03%]
药物研发中的角膜上皮模型的安全评估：现状与未来方向
Rodi Kado Abdalkader,Takuya Fujita
Rodi Kado Abdalkader
The human corneal epithelial barrier plays a crucial role in drug testing studies, including drug absorption, distribution, metabolism, and excretion (ADME), as well as toxicity testing during the preclinical stages of drug development. How...
The SNTB1 and ZFHX1B gene have susceptibility in northern Han Chinese populations with high myopia [0.03%]
SNTB1和ZFHX1B基因与中国北方汉族人高度近视的相关性分析
Lin Yang,Youmei Xu,Pengyi Zhou et al.
Lin Yang et al.
The aim of this study was to explore the association between SNTB1 and ZFHX1B polymorphisms and high myopia (HM) in a Northern Han Chinese population. This case-control study included 457 HM and 860 healthy subjects from the Northern Han Ch...
Synergic effects of EP2 and FP receptors co-activation on Blood-Retinal Barrier and Microglia [0.03%]
EP2和FP受体共激活对血视网膜屏障和小胶质细胞的协同效应
Natsuko Nakamura,Megumi Honjo,Reiko Yamagishi et al.
Natsuko Nakamura et al.
Macular edema (ME) is caused with disruption of the blood-retinal barrier (BRB) followed by fluid accumulation in the subretinal space. Main components of the outer and inner BRB are retinal pigment epithelial (RPE) cells and retinal microv...
Innovative cold atmospheric plasma (iCAP) decreases corneal ulcer formation and bacterial loads and improves anterior chamber health in methicillin resistant Staphylococcus aureus keratitis [0.03%]
创新性冷冻大气等离子(iCAP)可减少耐甲氧西林金黄色葡萄球菌角膜炎的角膜溃疡形成和细菌负荷并改善前房健康状况
Mary A Carr,Mary E Marquart,Miguel Sanchez et al.
Mary A Carr et al.
Bacterial keratitis is a vision-threatening infection of the cornea that is typically treated with antibiotics. However, antibiotics sometimes fail to eradicate the infection and do not prevent or repair the damage caused directly by the ba...
Wenjing Wu,Yanzheng Song,Mingshen Sun et al.
Wenjing Wu et al.
This study aimed to identify the corneal metabolic biomarkers for moderate and high myopia in human. We enrolled 221 eyes from 221 subjects with myopia to perform the femtosecond laser small incision lenticule extraction (SMILE) surgery. Am...