Assessing the therapeutic effects of DPP4 Inhibitors on TGF-β2-induced Lens Opacity [0.03%]
评估DPP4抑制剂对TGF-β2致晶状体浑浊的治疗作用
Niki Talebian,Pei-Kang Liu,Joanne Lee et al.
Niki Talebian et al.
Posterior capsular opacification (PCO) is a common complication following cataract surgery, resulting from the epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs). PCO continues to represent a significant public health c...
GSK3β promotes p53/Nrf2-dependent expression of the stress response protein REDD2 in retinal Müller glia exposed to hyperlipidemic conditions [0.03%]
高血脂条件下GSK3β促进视网膜Müller胶质细胞中p53/Nrf2依赖的应激反应蛋白REDD2表达
Ashley M VanCleave,Siddharth Sunilkumar,Allyson L Toro et al.
Ashley M VanCleave et al.
The stress response proteins regulated in development and DNA damage (REDD)1 and REDD2 act as negative regulators of mechanistic target of rapamycin complex 1 (mTORC1). While the role of REDD1 in diabetes complications in the retina has bee...
Corrigendum to "Stachydrine mitigates high glucose-induced apoptosis in human lens epithelial cells by activating mitophagy" [Exp. Eye Res. 260 (2025) 110568] [0.03%]
“stachydrine通过激活线粒体自噬来缓解高糖诱导的人晶状上皮细胞凋亡”的勘误证
Guijia Wu,Xiteng Chen,Wei Wang et al.
Guijia Wu et al.
Published Erratum
Experimental eye research. 2026 Mar 6:110941. DOI:10.1016/j.exer.2026.110941 2026
Differential susceptibility of rat retinal neurons to the Na+/K+-ATPase inhibitor ouabain [0.03%]
乌本苷对大鼠视网膜神经元的差异化敏感性研究
Ryosuke Odaka,Akane Morita,Toshihide Kashihara et al.
Ryosuke Odaka et al.
Na+/K+-ATPase (NKA) is an important transporter responsible for maintaining intracellular ion homeostasis. To identify retinal cell types most susceptible to NKA inhibition, we examined the effects of ouabain, an NKA inhibitor, on different...
Identification of immune cell subsets involved in retinal ganglion cell damage following blast exposure [0.03%]
爆炸损伤后参与视网膜神经节细胞损害的免疫细胞亚群鉴定
Matthew M Harper,Merri-Grace Jones,Oliver W Gramlich et al.
Matthew M Harper et al.
Traumatic brain injury from blast exposure (bTBI) has been shown to cause functional and structural retinal ganglion cell (RGC) damage. Previous studies have shown the immune system is activated following blast exposure and that adoptive tr...
SIRT3 mediates mitochondrial protection and attenuates mtROS-TXNIP-NLRP3 signaling activation in dry eye disease [0.03%]
SIRT3介导线粒体保护并减轻干眼病中的mtROS-TXNIP-NLRP3信号激活反应
Di Zhang,Yun He,Fan Yang et al.
Di Zhang et al.
Background/aim: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface in which mitochondrial dysfunction and oxidative stress have been increasingly implicated, yet the molecular mechanisms linkin...
José Hurst,Julia Alber,Julian Bredehorst et al.
José Hurst et al.
Retinal and choroidal vascular diseases are the leading causes of vision loss, with diabetic retinopathy and neovascular age-related macular degeneration as prominent examples. Current treatments such as laser photocoagulation and anti-VEGF...
Immunohistochemistry analysis of P16INK4a in pre-invasive ocular surface squamous neoplasia tissue samples infected and not infected by human papilloma virus at an academic laboratory in Northern Tshwane [0.03%]
北方茨瓦内在学术实验室中对人乳头瘤病毒感染和未感染的ocular表面鳞状上皮内病变组织样本中的P16INK4a进行免疫组化分析
Lucia Naddy Mhlongo,Cornelius Muzi Nkosi,Moshawa Calvin Khaba
Lucia Naddy Mhlongo
Ocular surface squamous neoplasia (OSSN) encompasses a wide range of benign and malignant tumours that arise from the conjunctiva and cornea. Tumour progression involves various genetic and epigenetic changes affecting oncogenes. The tumour...