Metabolomics for identifying pathways involved in vesicating agent lewisite-induced corneal injury [0.03%]
代谢组学在鉴定VESICATING机构路易氏剂诱导的角膜损伤涉及的途径中的作用
Neha Mishra,Rama Kant,Dinesh G Goswami et al.
Neha Mishra et al.
Lewisite (LEW) is an arsenical vesicant that can be a potentially dangerous chemical warfare agent (CWA). Eyes are particularly susceptible to vesicant induced injuries and ocular LEW exposure can act swiftly, causing burning of eyes, edema...
A simplified protocol to induce hypoxia in a standard incubator: A focus on retinal cells [0.03%]
一种在标准孵箱中诱导缺氧的简化方法：以视网膜细胞为重点
Bhavneet Kaur,Bruna Miglioranza Scavuzzi,Steven F Abcouwer et al.
Bhavneet Kaur et al.
Hypoxia chambers have traditionally been used to induce hypoxia in cell cultures. Cellular responses to hypoxia can also be mimicked with the use of chemicals such as cobalt chloride (CoCl2), which stabilizes hypoxia-inducible factor alpha-...
Artesunate mitigates choroidal neovascularization and scar formation [0.03%]
Arteşun酸可能减轻脉络膜新生血管及瘢痕形成
Nader Sheibani,Yong-Seok Song,Mitra Farnoodian et al.
Nader Sheibani et al.
Angiogenesis, although required during eye development, has a causative effect in many ocular diseases. Aberrant neovascularization contributes to the progression of neovascular age-related macular degeneration (nAMD), a vision-threaten dis...
Predicting clinical outcome of sulfur mustard induced ocular injury using machine learning model [0.03%]
使用机器学习模型预测二硫化碳所致眼损伤的临床预后
Vered Horwitz,Maayan Cohen,Ariel Gore et al.
Vered Horwitz et al.
The sight-threatening sulfur mustard (SM) induced ocular injury presents specific symptoms in each clinical stage. The acute injury develops in all exposed eyes and may heal or deteriorate into chronic late pathology. Early detection of eye...
Gender-specific lncRNA-miRNA-mRNA regulatory network to reveal potential genes for primary open-angle glaucoma [0.03%]
性别特异性长链非编码RNA-微小RNA-信使RNA调控网络用于发现原发性开角型青光眼的潜在基因
Jingxia Chen,Chu Zhang,Jinyan Peng et al.
Jingxia Chen et al.
Background: Investigation of biomarkers may facilitate understanding the mechanisms of primary open-angle glaucoma (POAG) and developing therapeutic targets. This study aimed to identify potential genes based on competing...
Host cell-type and pathogen-specific immunomodulatory functions of macrophage migration inhibitory factor (MIF) in infectious keratitis [0.03%]
巨噬细胞移行抑制因子(MIF)在感染性角膜炎中的免疫调节功能具有宿主细胞类型和病原体特异性
Swagata Ghosh,A H Humera Khathun,G S Athulya et al.
Swagata Ghosh et al.
Therapeutic management of inflammation in infectious keratitis (IK) requires new strategy and targets for selective immunomodulation. Targeting host cell-type specific inflammatory responses might be a viable strategy to curtail unnecessary...
Development and validation of a reliable rabbit model of limbal stem cell deficiency by mechanical debridement using an ophthalmic burr [0.03%]
一种新的兔眼睑缘干细胞缺损动物模型的建立及验证——角膜抛磨术治疗机械性切除睑缘边缘干细胞缺陷的实验研究
Vijay Kumar Singh,Abhinav Reddy Kethiri,Tejaswini Pingali et al.
Vijay Kumar Singh et al.
A simple and reproducible method is necessary to generate reliable animal models of limbal stem cell deficiency (LSCD) for assessing the safety and efficacy of new therapeutic modalities. This study aimed to develop and validate a rabbit mo...
Activation of p38 MAPK hinders the reactivation of visual cortical plasticity in adult amblyopic mice [0.03%]
激活p38 MAPK抑制了成人弱视小鼠视觉皮层可塑性的恢复
Guiqu Wang,Peixian Hou,Yanqiong Tu et al.
Guiqu Wang et al.
Objective: To investigate the impact of p38 mitogen-activated protein kinase (MAPK) signaling on reactivating visual cortical plasticity in adult amblyopic mice. ...
Comparison of different lipid staining methods in human meibomian gland epithelial cells [0.03%]
人睑板腺上皮细胞不同脂质染色方法的比较研究
Yang Liu,Shan Yang,Xiaomin Chen et al.
Yang Liu et al.
This study aimed to compare the utility of four different dyes for intracellular lipid detection in immortalized human meibomian gland epithelial cells (IHMGECs). IHMGECs were cultured in a serum-containing medium for 10 days in the presenc...
A negative feedback loop centered on SMAD3 expression in transforming growth factor β1-induced corneal myofibroblast differentiation [0.03%]
转化生长因子诱导角膜肌成纤维细胞分化中心的SMAD3表达负反馈环机制研究
Yunlan Tang,Enming Du,Gang Wang et al.
Yunlan Tang et al.
SMAD3 downregulation is documented in transforming growth factor β1 (TGF-β1)-induced corneal fibroblasts differentiation to myofibroblasts ("fibroTOmyoDiff") or corneal wound healing. However, the exact regulatory mechanism of TGF-β1/SMA...