A core innate immune gene panel derived from germ-free larval zebrafish transcriptomics resolves strain-specific induction by Aeromonas veronii and Lacticaseibacillus rhamnosus GG [0.03%]
基于无菌斑马鱼转录组学鉴定出一组核心固有免疫基因，可解析Aeromonas veronii和Lacticaseibacillus rhamnosus GG的菌株特异性诱导作用
Xiang-Ru Liu,Ying Liu,Chen-Cong Zhang et al.
Xiang-Ru Liu et al.
The intestinal microbiota is critical for innate immune maturation in fish, yet candidate probiotics and commensals are often evaluated using narrow inflammatory readouts that may obscure strain-specific immune programs. Here, we developed ...
Multi-tissue transcriptomics reveals age-dependent susceptibility to grass carp reovirus linked to metabolic alterations and extracellular matrix disruption in grass carp [0.03%]
多组织转录组揭示年龄依赖性草鱼呼肠孤病毒易感性与代谢改变和细胞外基质破坏有关
Qi Fang,Bo Wang,Yingyin Cheng et al.
Qi Fang et al.
Grass carp (Ctenopharyngodon idella) is an important freshwater aquaculture species. Infection by grass carp reovirus (GCRV) can cause hemorrhagic disease and lead to major economic losses in aquaculture. Susceptibility to GCRV is strongly ...
Genome-wide identification of the cystatin gene family and functional characterization of cystatin B in flathead mullet (Mugil cephalus) [0.03%]
莫桑鱼（Mugil cephalus） cystatin基因家族的全基因组鉴定及其 cystatin B的功能表征
Yuqing Chen,Dianyang Zhou,Fei Li et al.
Yuqing Chen et al.
The cystatin superfamily is a class of endogenous cysteine protease inhibitors that play a key role in immune regulation and host defense. However, there remains a lack of genome-wide identification and functional studies of this gene famil...
Betanodavirus induces RIPK3/MLKL-mediated necroptosis and IL-21/adaptive immune response via superoxide stress/mTOR/ULK1-mediated autophagy signal in the context of brain damage in grouper (Epinephelus coioides) [0.03%]
鱼嗜神经病毒通过超氧化物应激/mTOR/ULK1介导的自噬信号诱导RIPK3 / MLKL介导的坏死性凋亡和IL-21/适应性免疫反应参与石斑鱼脑损伤
Hong-Jun Liao,Kuang-Wen Chen,Hsing-Ni Lin et al.
Hong-Jun Liao et al.
Betanodavirus infection induces viral nervous necrosis (VNN) in fish. However, the role of macroautophagy/autophagy in the pathogenesis of VNN remains unknown. In this study, we found that RGNNV can trigger a superoxide-induced stress signa...
An effective combined vaccine against vibriosis and typical and atypical furunculosis in Atlantic salmon (Salmo salar) [0.03%]
一种有效的结合疫苗可同时预防大西洋鲑鱼（Salmo salar）患气单胞菌病和典型及非典型的肤病
YoungJun Park,Hyun-Ja Han,Myoung Sug Kim et al.
YoungJun Park et al.
This study evaluated the safety and efficacy of a novel trivalent inactivated vaccine targeting domestic strains of Vibrio anguillarum (VA), Aeromonas salmonicida subsp. salmonicida (ASS), and A. salmonicida subsp. masoucida (ASM) in Atlant...
Comparative Analysis of Early Immune Responses in Zebrafish Infected with Carbapenem-Resistant and Carbapenem-SusceptibleKlebsiella pneumoniaeStrains [0.03%]
碳青霉烯敏感和耐药肺炎克雷伯菌早期感染斑马鱼免疫反应的比较研究
Yunhong Yi,Jiajie Liu,Xiaosong Yang et al.
Yunhong Yi et al.
Carbapenem-resistantKlebsiella pneumoniae (CRKP) poses a critical public health threat with limited treatment options and high mortality, yet its immune evasion strategies remain poorly understood compared to carbapenem-susceptible strains ...
Excitotoxicity and PANoptosis are examined through endoplasmic reticulum stress of brain in the fat greenling (Hexagrammos otakii) under hypoxic stress [0.03%]
缺氧胁迫下六线拟鳞虾虎鱼脑内兴奋毒性及PANoptosis的内分泌素损伤诱导机制研究
Yiting Wu,Rangman Liu,Xinying Zhang et al.
Yiting Wu et al.
Hypoxia can cause brain injury in fish, resulting in neurological sequelae of varying severity. This is a key contributor to anorexia, delayed development, and even fish mortality. Endoplasmic reticulum stress (ERS)-mediated PANoptosis is e...
iTRAQ-based proteomic identification of cyclophilin as a candidate mediator for cyclosporin A-mediated immunomodulation in pearl oysters Pinctada fucata martensii [0.03%]
基于iTRAQ的蛋白质组学鉴定环孢菌素A介导的珍珠牡蛎(Pinctada fucata martensii)免疫调节候选介质蛋白:cyclophilin蛋白质功能研究
Guixuan Chen,Hao Zhong,Ming Zhang et al.
Guixuan Chen et al.
Transplantation surgery induces severe immune stress in pearl oysters Pinctada fucata martensii, yet effective immunomodulatory strategies remain limited. This study establishes a proteomics-guided strategy for immunomodulation by identifyi...
Functional Characterization of AgIQCG in Red-Blood Trait Maintenance of the Blood Clam Anadara granosa [0.03%]
血蛤红细胞性状维持相关AgIQCG基因的功能分析研究
Mengshi Zhang,Lun Li,Jiangjiang Zhu et al.
Mengshi Zhang et al.
The blood clam (Anadara granosa) is a distinctive bivalve species characterized by red hemolymph and pronounced red-blood traits. However, the molecular basis underlying the maintenance of these traits remains unclear. In our previous genom...
Antibody-dependent immune response of olive flounder (Paralichthys olivaceus) induced by inactivated viral hemorrhagic septicemia virus (VHSV) vaccine [0.03%]
灭活病毒性出血败血症病毒(VHSV)疫苗诱导橄榄拟丽鱼(ParlIchthysolivaceus)的抗体依赖性免疫反应
Jin-Young Kim,Feberose Castro,Su-Mi Shin et al.
Jin-Young Kim et al.
In teleosts, vaccine-induced protection is commonly assessed using serum antibody titers; however, these measurements often fail to fully explain protective outcomes due to limited understanding of B cell differentiation and antibody effect...