Negative regulation of RIG-I by STAT1a and STAT1b in the innate immunity of black carp [0.03%]
STAT1a和STAT1b通过负向调控RIG-I抑制乌斑蛙先天性免疫反应
Keqing Wang,Chushan Dai,Tian Qin et al.
Keqing Wang et al.
Signal transducer and activator of transcription 1 (STAT1) is a key component of the interferon (IFN) signaling pathway, in which retinoic acid-inducible gene I (RIG-I) functions as a key cytosolic viral RNA sensor. However, the role of STA...
HnRNPK promotes SVCV replication by stabilizing viral phosphoprotein and targeting IRF3 to suppress type I interferon response [0.03%]
hnRNPK通过稳定病毒磷酸蛋白并重新定位IRF3来抑制I型干扰素反应从而促进水貂适应性病毒复制
Yanwei Zhang,Xin Lin,Mingyi Li et al.
Yanwei Zhang et al.
Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a multifunctional RNA-binding protein implicated in various cellular processes, yet its role in fish antiviral immunity and viral replication remains poorly understood. In this study, we...
Astragalus polysaccharides alleviate oxidative damage by activating the Keap1-Nrf2 antioxidant pathway through miR-183-5p in a fish cell model [0.03%]
黄芪多糖通过miR-183-5p激活鱼细胞模型中的Keap1-Nrf2抗氧化途径从而缓解氧化损伤作用
Yongyang Wang,Huimin An,Fanfan Ma et al.
Yongyang Wang et al.
Astragalus polysaccharides (APS), one of the star antioxidants among traditional Chinese medicine, have widespread applications in healthcare, veterinary, and fishery fields. However, the mechanisms underlying their antioxidative action rem...
Epinephelus coioides lnc32039 promotes the infection of Iridovirus SGIV via inhibiting immune response and apoptosis [0.03%]
Epinephelus coioides lnc32039通过抑制免疫反应和细胞凋亡促进虹彩病毒SGIV的感染
Yin-Mei Lan,Wen-Feng Yang,Yu-Qin Ma et al.
Yin-Mei Lan et al.
Long non-coding RNAs (lncRNAs) play important roles in the infection of pathogen. In this study, the role of the lncRNA lnc32039 in Epinephelus coioides, the precious marine fish in China, was studied during Singapore grouper iridovirus (SG...
Sexual dimorphism of antiviral immunity in grass carp (Ctenopharyngodon idella): TLR7 and TLR8b promote resistance to GCRV in males, whereas TLR8a increases susceptibility in females [0.03%]
草鱼抗病毒免疫的性别二态性：TLR7和TLR8b使雄鱼更具有GCRV抵抗性，而TLR8a则增加雌鱼的易感性
Jingjing Zhang,Shijie Wang,Yuezong Xu et al.
Jingjing Zhang et al.
Sexual dimorphism of immune responses is widespread in vertebrates. In mammals, Toll-like receptor 7 (TLR7) and TLR8 are tandemly localized on the X chromosome and constitute the key molecular basis for sex-biased immunity. However, most te...
A novel antimicrobial peptide Spamprin4-23 from Scylla paramamosain exhibiting potent antimicrobial activity and protective effects against Vibrio alginolyticus [0.03%]
一种新型抗菌肽Spamprin4-23具有强大的抗菌活性和抗沙林氏弧菌保护作用
Xuewu Zhu,Weibin Zhang,Shuang Li et al.
Xuewu Zhu et al.
Vibrio species are ubiquitous in aquatic environments and represent significant pathogens in marine aquaculture, with Vibrio alginolyticus being a primary threat to farmed aquatic animals. The limited availability of therapeutic drugs in aq...
Adjuvanted Edwardsiella anguillarum vaccine confers protection and cross-protection against E. piscicida in Japanese eel (Anguilla japonica) [0.03%]
类腮病沙雷氏菌（Edwardsiella tardilytica）疫苗可诱导日本鳗鱼对点状 Edwardsiella 产生免疫保护力
Hyeon-Gyeong Kim,Jin-Young Kim,Wi-Sik Kim et al.
Hyeon-Gyeong Kim et al.
Edwardsiellosis, caused by Edwardsiella species, is a major bacterial disease in eel aquaculture in East Asia. However, effective vaccines for Japanese eel (Anguilla japonica) remain unavailable. In this study, a formalin-killed Edwardsiell...
Establishment and antiviral immune response characterization of fin cell lines from black carp (Mylopharyngodon piceus) and gynogenetic black carp [0.03%]
许氏平鮠及二倍体许氏平鮭鳍细胞系的建-establishment和抗病毒免疫反应特征分析-characterization
Wei Qin,Linxi Cai,Mengru Liu et al.
Wei Qin et al.
Grass carp reovirus (GCRV) and spring viremia of carp virus (SVCV) cause high mortality in black carp. We have previously bred a gynogenetic black carp strain with enhanced antiviral resistance. To investigate the underlying mechanisms, we ...
Autochthonous probiotic Lactococcus lactis MA5 improves recovery from acute hypoxia stress and resistance to Edwardsiella ictaluri in hybrid catfish (Ictalurus punctatus × I. furcatus) [0.03%]
土著益生菌乳链球菌MA5可改善沟虹吸鲤（Ictalurus punctatus×I.furcatus）急性缺氧应激恢复及伊氏杀鱼 Edwardsiella ictaluri 抗性
Jing Huang,Caitlin E Older,Taylor I Heckman et al.
Jing Huang et al.
Dietary supplementation with probiotics is considered an effective strategy to enhance aquaculture production efficiency and disease resistance. Recent research has highlighted the value of using autochthonous probiotics in aquaculture. Her...
Classification of hemocyte subpopulations in the clam Meretrix Petechialis and their differential immune-associated responses to Vibrio infection [0.03%]
金丝雀藤壶血细胞的分类及其对维氏弧菌感染的不同免疫应答
Jing Tian,Hongxia Wang,Pin Huan et al.
Jing Tian et al.
Vibrio infection severely threatens the sustainability of the clam aquaculture industry. As the primary defenders in bivalve mollusks, hemocytes are crucial for immunity, yet their subpopulations and functional specialization are not fully ...