Hypoxia increases susceptibility of grass carp to Aeromonas hydrophila infection by inducing oxidative stress and impairing antimicrobial defense [0.03%]
低氧通过诱导氧化应激和抑制鱼的抗菌免疫应答增加草鱼对嗜水气单胞菌感染的易感性
Yang Jin,Ziquan Yang,Jiamin Liu et al.
Yang Jin et al.
Hypoxia is a major environmental stressor that threatens fish health in intensive aquaculture, particularly when it co-occurs with bacterial infection. To clarify how hypoxia influences host responses to Aeromonas hydrophila, we established...
β-globin mediates antimicrobial defense and inflammatory regulation in common carp (Cyprinus carpio) [0.03%]
β-珠蛋白介导鲤鱼的抗菌防御和炎症调节
Xiuying Cui,Chenfan Zhao,Zhaohui Jin et al.
Xiuying Cui et al.
β-globin is a core subunit of hemoglobin, playing an indispensable role in oxygen transport, but its immunological functions have been less extensively characterized. In this study, we identified and characterized the β-globin gene from C...
PcTRIM23 knockdown correlates with increased WSSV replication, hepatopancreatic apoptosis, and ROS accumulation in Procambarus clarkii [0.03%]
克氏盒苇虾PcTRIM23基因沉默与WSSV复制增强、肝胰腺细胞凋亡和ROS积累增多相关性研究
Chao Peng,Liye Shao,Ronghua Wang et al.
Chao Peng et al.
This study aimed to clone and identify the TRIM23 gene (designated as PcTRIM23) from Procambarus clarkii and investigate its immune function during white spot syndrome virus (WSSV) infection. The open reading frame (ORF) of PcTRIM23 was 171...
A cell-penetrating peptide Pep-1 fused nanobody Nb24 targeting VP28 inhibits WSSV replication in crayfish Procambarus clarkii [0.03%]
一种穿膜肽Pep-1融合的靶向WSSV衣壳蛋白VP28的纳米抗体Nb24抑制对钳形螯虾病毒增殖
Xuemin Wei,Shunqiang Wei,Chushun Yi et al.
Xuemin Wei et al.
White spot syndrome virus (WSSV) is a fatal pathogen responsible for significant economic losses in the global crustacean industry, and there are no effective commercial therapeutic drugs available for controlling the spread of WSSV. Nanobo...
SNX8 interacts with THOC7 to negatively regulate IFN 1 response via the TBK1-IRF3 signaling axis in teleost fish [0.03%]
鱼类SNX8通过TBK1-IRF3信号轴与THOC7相互作用以负向调节I型干扰素反应
Miao-Miao Li,Chu-Xin Wu,Ji-Huan Hu et al.
Miao-Miao Li et al.
Teleost sorting nexin 8 (SNX8) negatively regulates antiviral innate immunity, but its precise mechanism remains unclear. Here, using IP and LC-MS/MS analyses, we identified grass carp THOC7 (CiTHOC7) as a candidate protein that interacts w...
Hematology-centered profiling of compartmentalized kidney and peripheral blood responses during controlled Vibrio anguillarum infection in mandarin fish (Siniperca chuatsi) [0.03%]
黄尾fish可控型Vibrio anguillarum感染条件下肾脏和外周血分隔反应的血液学分析中心 profiling(名词）：指对生物体或系统的多个方面进行全面测量和评估的过程，在这里具体指的是对黄尾鱼在特定细菌感染条件下的多方面反应进行综合分析。
Bhashini Prasadika Waidyarathna,Su-Mi Shin,Seok-Ju Lee et al.
Bhashini Prasadika Waidyarathna et al.
Vibriosis caused by Vibrio anguillarum (V. anguillarum) is a major bacterial disease in aquaculture; however, systemic hematological responses during infection remain poorly understood. In this study, mandarin fish (Siniperca chuatsi) were ...
Structural integrity of surface antigens determines complement-dependent protective immunity against Philasterides dicentrarchi in turbot [0.03%]
表层抗原的结构完整性决定了欧洲扁舵/oct鱼对Philasterides dicentrarchi补体依赖性保护免疫能力
P Gulías,R A Sueiro,J Lamas et al.
P Gulías et al.
Scuticociliatosis caused by Philasterides dicentrarchi is a major constraint for turbot (Scophthalmus maximus) aquaculture, yet the molecular identity and immunological relevance of parasite surface antigens remain poorly defined. This stud...
Identification and functional characterization of interferon-c (IFNc) in orange-spotted grouper (Epinephelus coioides) involved in antiviral response to SGIV and RGNNV infections [0.03%]
干涉素-γ（IFN-γ）在石斑鱼中参与抗病毒应答的鉴定和功能表征
Yanjie Shi,Rui Jiang,Xiaotian Zhuo et al.
Yanjie Shi et al.
The orange-spotted grouper (Epinephelus coioides) is highly susceptible to viral pathogens such as Singapore grouper iridovirus (SGIV) and red-spotted grouper nervous necrosis virus (RGNNV), resulting in significant economic losses in aquac...
An LNP-encapsulated mRNA vaccine targeting the major capsid protein of largemouth bass virus confers protective immunity and reduces RIG-I pathway activation in Micropterus salmoides [0.03%]
一种针对大口黑鲈病毒主要衣壳蛋白的LNP封装型mRNA疫苗可赋予小梭鱼保护性免疫并降低其RIG-I途径活化水平
Yujun Liu,Gengrong Zhang,Haozhe Qu et al.
Yujun Liu et al.
Largemouth bass virus (LMBV) infection poses a significant threat to largemouth bass farming in China, yet effective and safe vaccines remain scarce. In this study, we designed and evaluated four mRNA vaccine candidates against LMBV, all en...
Development and immune evaluation of a LAMP-targeted TolC II DNA vaccine delivered by mannosylated chitosan against Aeromonas veronii in crucian carp (Carassius auratus) [0.03%]
壳聚糖甘露糖衍生物介导的斑马鱼LAMP-TolC II DNA疫苗免疫效果研究
Shaoyu Hu,Junlei Cheng,Liangliang Ma et al.
Shaoyu Hu et al.
Crucian carp (Carassius auratus) is one of the major freshwater aquaculture species in China and is frequently threatened by motile Aeromonas septicemia (MAS), a major bacterial disease closely associated with Aeromonas veronii infection in...