Common carp USP30s restrict SVCV replication by attenuating mitophagy [0.03%]
美国鲤鱼USP30通过减弱线粒体自噬限制SVCV复制
Chen Li,Songjie Qi,Mengxi Zhang et al.
Chen Li et al.
As a selective autophagic process, mitophagy is deeply involved in antiviral immunity by eliminating damaged mitochondria and requires the participation of various enzymes. Among these, the deubiquitinating enzyme USP30 is known to regulate...
Epigallocatechin-3-gallate attenuates the immunotoxicity of sulfamethoxazole and reduces its residues in crayfish via phagocytosis [0.03%]
表没食子儿茶素没食子酸酯通过促进吞噬作用削弱磺胺甲恶唑的免疫毒性并降低残留风险
Yilin Li,Yujie Zhao,Fei Zhu
Yilin Li
Epigallocatechin-3-gallate (EGCG) has been demonstrated to effectively mitigate the immunotoxic effects induced by sulfamethoxazole (SMX) exposure in the crayfish Procambarus clarkii, primarily through the activation of the endocytosis path...
LvBlimp1 and LvHes1 coregulate the function of macrophage-like phagocytes in shrimp hemolymph [0.03%]
LvBlimp1和LvHes1协同调节虾血淋巴类巨噬细胞的功能
Jiaming Liu,Yaohui Chen,Wenyong Jiang et al.
Jiaming Liu et al.
B-lymphocyte-induced maturation protein 1 (Blimp1) is a highly conserved transcription factor that governs cell fate specification in metazoan. In this study, we identified LvBlimp1 as a stress-responsive protein in shrimp hemolymph. Functi...
Functional remodeling of IgM+ B cells in Streptococcus agalactiae-resistant Nile tilapia [0.03%]
抗凝固芽胞杆菌的尼罗罗非鱼IgM+B细胞的功能重塑
Yuying Zheng,Ding Wang,Jialong Yang et al.
Yuying Zheng et al.
Streptococcus agalactiae infection remains a major constraint on the productivity of Nile tilapia (Oreochromis niloticus), a species of considerable economic importance in global aquaculture. Although selective breeding programs have succes...
Generation and application of monoclonal antibodies against CD4-1 and CD8α for characterizing T cell subsets in grass carp (Ctenopharyngodon idella) [0.03%]
用于鉴别草鱼(Ctenopharyngodon idella)T淋巴细胞亚群的CD4-1和CD8α单克隆抗体的制备及应用
Haokai Chen,Ming Geng,Kang Li et al.
Haokai Chen et al.
Mature T cells are functionally specialized through differential expression of CD4 or CD8, with CD4+ cells designated as helper T cells (Th cells) and CD8+ cells as cytotoxic T lymphocytes (CTLs). However, due to the lack of antibody tools,...
Temperature during vaccination shapes antibody responses and protection against infectious salmon anemia in Atlantic salmon under different prime-boost vaccine strategies [0.03%]
温度对三文鱼疫苗接种后抗体反应和感染性脾脏 анemia保护力的影响不同的基础免疫和加强免疫策略
Manuel Soto-Dávila,Shona K Whyte,Ruth L Quispe et al.
Manuel Soto-Dávila et al.
Vaccination is crucial for Atlantic salmon farming, protecting against bacterial and viral infections, such as infectious salmon anemia (ISA) caused by infectious salmon anemia virus (ISAV). Salmon immune responses are highly temperature-de...
An immunoinformatics-derived multi-epitope DNA vaccine targeting the Micropterus salmoides rhabdovirus G protein elicits protective immunity in largemouth bass [0.03%]
一种针对Micropterus salmoides病毒G蛋白的多表位DNA疫苗诱导斑口鱼保护性免疫的免疫信息学研究
Zhenning Yu,Boge Gu,Qianhui Gui et al.
Zhenning Yu et al.
Largemouth bass (Micropterus salmoides) is a commercially important freshwater aquaculture species. However, the sustainable development of this industry is severely threatened by Micropterus salmoides rhabdovirus (MSRV), a critical pathoge...
Dopamine receptor (DAR) is required for the antibacterial immune responses in hemocytes of Procambarus clarkii [0.03%]
多巴胺受体(DAR)参与克氏原螯虾血细胞抗菌免疫响应
Jing Wen,Mingyue Tan,Zeyu Feng et al.
Jing Wen et al.
Dopamine receptors (DARs) are a type of evolutionarily conserved G-protein-coupled receptors, which are capable of coordinating the interactions between neuroendocrine and immune systems. However, their roles in the systemic antibacterial i...
Cyprinid herpesvirus 3 ORF24 facilitates viral replication via RLR signaling pathway-mediated innate immune evasion [0.03%]
Cyprinid herpesvirus 3ORF24通过模式识别受体信号通路介导的天然免疫逃逸促进病毒复制
Chi Zhang,Qian Liu,Yaqian Bai et al.
Chi Zhang et al.
Cyprinid herpesvirus 3 (CyHV-3) poses a significant threat to common carp aquaculture, yet the mechanisms underlying its immune evasion remain poorly understood. In this study, we identify the viral protein ORF24 as a critical antagonist of...
Dietary Periplaneta americana chitin maintains inflammatory homeostasis and enhances innate immunity in juvenile common carp (Cyprinus carpio) via the Nrf2/NF-κB network [0.03%]
美洲大蠊虫壳通过Nrf2/NF-κB网络维持斑马鱼炎症稳态和提高先天免疫能力
Jingjing Gao,Xiaofang Zou,Qiujie Chen et al.
Jingjing Gao et al.
This study systematically investigates the immunomodulatory and antioxidant properties of dietary chitin derived from the American cockroach (Periplaneta americana) in juvenile common carp (Cyprinus carpio), with emphasis on its tissue-depe...