A Teleost NK-Lysin Derived Peptide Inhibits SVCV Infection by Disruption Viral Adhesion/Entry and Activating Type I Interferon Response [0.03%]
一种金鱼NK-lysin衍生肽通过破坏病毒黏附/侵入及激活I型干扰素信号抑制SVCV感染
Zi-Yue Chen,Bing Wang,Zhi-Shu Zhu et al.
Zi-Yue Chen et al.
NK-lysin, a member of the saposin-like protein family, is a potent antimicrobial peptide that plays a key role in host defense against various pathogens. However, research on its antiviral activity and underlying mechanisms remains limited....
Dietary lutein mitigates high fat diet and lipopolysaccharide induced intestinal barrier dysfunction and immune inflammatory responses in juvenile black seabream (Acanthopagrus schlegelii) [0.03%]
叶黄素通过改善肠道屏障功能缓解黑石斑鱼肠上皮细胞炎症免疫反应
Yangguang Bao,Jiayun Zhu,Qiuting Yang et al.
Yangguang Bao et al.
High-fat diets (HFDs) can impair intestinal homeostasis and innate immune function in fish, whereas nutritional immunomodulation may provide an effective strategy to improve immune response to LPS challenge in aquaculture species. This stud...
Combined berberine and glycyrrhetinic acid treatment confers antiviral and host-protective effects against CAPRV2023 infection in golden pompano (Trachinotus anak) [0.03%]
combined使用小檗碱和甘草酸治疗可协同抑制CAPRV2023感染并保护金线鱼宿主健康
Weicong Li,Heng Sun,Haoyu Wang et al.
Weicong Li et al.
Carpione rhabdovirus 2023 (CAPRV2023) is an emerging, highly pathogenic pathogen infecting Golden pompano (Trachinotus anak), capable of triggering mass mortality in marine aquaculture populations and causing severe economic losses. Berberi...
Identification of Nesfatin-1 in primitive vertebrate lampreys and its roles in inflammatory responses and ferroptosis [0.03%]
七鳃鳗nesfatin-1的鉴定及其在炎症反应和铁死亡中的作用
Mengqian He,Yaocen Wang,Yitong Li et al.
Mengqian He et al.
Nesfatin-1 is an 82-amino acid polypeptide derived from the precursor protein nucleobindin 2 (NUCB2), which is a conserved multifunctional peptide in vertebrates that plays a key role in metabolic regulation, inflammatory response and ferro...
Zebrafish RNF128a positively regulates innate immunity by promoting the K63-linked ubiquitination of TBK1 [0.03%]
RNF128a通过促进TBK1的K63连接泛素化正向调节斑马鱼固有免疫反应
Zeyin Jiang,Jihuan Hu,Hongying Zhang et al.
Zeyin Jiang et al.
RNF128, also known as GRAIL, is a well-studied E3 ubiquitin ligase involved in the induction and maintenance of T cell anergy. It contains PA_GRAIL_like domain, HRD1 domain and RING-H2_like domain. Recent studies have shown that RNF128 is i...
Molecular characterization, microbial recognition and immunomodulatory functions of a novel ladderlectin-like lectin (HoLL-like) from Hexagrammos otakii [0.03%]
Hexagrammos otakii新型梯状凝集素类似物(HoLL-like)的分子特性、微生物识别及免疫调节功能研究
Yuyoumin Wen,Xuya Wei,Tingting He et al.
Yuyoumin Wen et al.
Ladderlectin, a member of the C-type lectin (CTL) family, has historically been identified only in fish and shrimp, where it is primarily involved in innate immune defense. In teleosts, ladderlectin plays a crucial dual role in both innate ...
Hematology-centered characterization of β-glucan-mediated disease trajectory modulation during rock bream iridovirus (RBIV) infection [0.03%]
β-葡聚糖介导感染硬鳞弹状病毒期间以血液学为中心的疾病进程改变特征描述
Su-Mi Shin,Da-Seul Lee,Seok-Ju Lee et al.
Su-Mi Shin et al.
Rock bream iridovirus (RBIV) causes a rapid systemic infection, severe hematological disruption, and high mortality in rock bream (Oplegnathus fasciatus). Although β-glucan is widely used as an immunostimulant in aquaculture, its influence...
Genome-wide identification of the cystatin gene family in Japanese flounder (Paralichthys olivaceus) and functional characterization of PoCystatin B and PoCystatin C [0.03%]
半滑舌鳎（Paralichthysolivaceus）胱抑素基因家族的全基因组鉴定及PoCystatinB和PoCystatinC的功能分析
Xiangru Li,Ping Han,Yadong Xue et al.
Xiangru Li et al.
Members of the cystatin superfamily serve as key regulators of cysteine protease activity that play critical roles in immune defense and inflammatory regulation, yet systematic studies on this family in Japanese flounder (Paralichthys oliva...
PlCXCL12a differentially modulates SGIV and RGNNV replication during single and co-infection and regulates chemotaxis-associated immune responses [0.03%]
PLCXD12a在单感染和共感染时对SGIV和RGNNV复制的调节作用及其对趋化因子相关免疫反应的影响
Jinpeng Chen,Shen Li,Yixiang Li et al.
Jinpeng Chen et al.
Chemokines play important roles in coordinating innate immune defense in teleost fish. In this study, a CXCL12a homolog, designated PlCXCL12a, was cloned and characterized from leopard coral grouper (Plectropomus leopardus). PlCXCL12a encod...
Thioredoxin 1 inhibits GCRV replication by maintaining redox homeostasis in grass carp (Ctenopharyngodon idella) [0.03%]
硫氧还蛋白1通过维持草鱼红氧化态平衡来抑制GCRV复制
Denghui Zhu,Xiaoya Wang,Liangming Chen et al.
Denghui Zhu et al.
Thioredoxin (Trx) is a conserved redox regulatory protein that plays critical roles in maintaining cellular redox homeostasis and immune defense. However, its molecular characteristics and antiviral functions in grass carp (Ctenopharyngodon...