The fermentative product from Bacillus siamensis HU603 (6'-phospho macrolactin B) inhibits Micropterus salmoides rhabdovirus infection in vitro and in vivo [0.03%]
芽孢杆菌株HU603的发酵产物（6-磷酸化大环内酯B）体内外抑制马口鱼病毒复制
Xinhui Tong,Yan Zhou,Qianhao Shao et al.
Xinhui Tong et al.
Micropterus salmoides rhabdovirus (MSRV) poses a substantial challenge to the health and sustainability of largemouth bass aquaculture. It causes huge economic losses, particularly in juvenile fish. However, there are still no effective the...
Functions of tandem-repeat galectins and domain coordination governs galectin-4 activity in grass carp (Ctenopharyngodon idella) [0.03%]
鲤鱼肠黏蛋白凝集素Cia-Lg4的串联重复序列功能及其与结肠黏蛋白凝集素结构域的相互作用关系研究
Hongzhou Xu,Tian Yang,Haixia Liu et al.
Hongzhou Xu et al.
Galectins are β-galactoside-binding lectins that play essential roles in innate immunity. Among them, tandem-repeat galectins (TrGals), typically composed of two distinct carbohydrate-recognition domains (CRDs) connected by a linker peptid...
The ELAVL gene family in large yellow croaker: LcELAVL1a is an immune-active member with direct antibacterial and cell-protective functions [0.03%]
大黄鱼的ELAVL基因家族：LcELAVL1a具有直接抗菌和细胞保护功能的免疫活性成员
Jiaxin Song,Rumeng Zhai,Dianyang Zhou et al.
Jiaxin Song et al.
The embryonic lethal abnormal vision-like (ELAVL) gene family encodes a group of conserved RNA-binding proteins involved in post-transcriptional regulation and immune function. In this study, five ELAVL family members (Lcelavl1a, Lcelavl1b,...
Pre-transport dietary chitosan improves the physiological robustness of juvenile largemouth bass (Micropterus salmoides) by modulating antioxidant and inflammatory responses [0.03%]
饲喂壳聚糖通过调节抗氧化和炎症反应提高青年黑鲈的生理稳健性
Hong-Zheng Zhao,Yu-Lin Chang,Chang Wang et al.
Hong-Zheng Zhao et al.
The acute stress caused by long-distance transport can lead to oxidative damage, immune dysfunction, and health deterioration in fish. This study evaluated dietary chitosan as a pre-transport nutritional strategy for juvenile largemouth bas...
Development of an oral Lactobacillus casei-based recombinant vaccine expressing GCRV-II multi-epitope fusion protein and its protective efficacy against grass carp hemorrhagic disease [0.03%]
一种口服免疫草鱼出血病的肠膜明串珠菌重组多表位融合蛋白疫苗及其保护效果研究
Xijia Chen,Yujiao Chen,Danwen Wang et al.
Xijia Chen et al.
Grass carp hemorrhagic disease caused by grass carp reovirus (GCRV) results in severe economic losses in aquaculture. Vaccination is an effective strategy for controlling viral infections. The subunit vaccines are considered promising becau...
Multi-omics analysis reveals stage-associated differences in gut immunity and microbiota between juvenile and adult common carp (Cyprinus carpio) [0.03%]
多组学分析揭示了草鱼（Cyprinus carpio）在幼年和成年阶段肠道免疫和微生物群的差异
Yu Huo,Chang Cai,Xinyou Wang et al.
Yu Huo et al.
In vertebrates, the development of intestinal immunity is closely associated with dynamic changes in the gut microbiota. However, stage-associated differences in intestinal immunity and gut microbial communities remain poorly characterized ...
Lactate facilitates largemouth bass virus replication by promoting cholesterol biosynthesis [0.03%]
乳酸通过促进胆固醇生物合成促进大口黑鲈病毒的复制
Xixi Guo,Ting Yu,Yin Zhao et al.
Xixi Guo et al.
Cellular metabolism has been hijacked by viruses for efficient replication due to their regulatory roles on both innate and adaptive immunity. Largemouth bass virus (LMBV), a member of Ranavirus, causes high mortality and severe economic lo...
Genome-wide identification and characterization of ABC transporters and their expression in response to saline-alkaline stress and WSSV infection in Fenneropenaeus chinensis [0.03%]
中国对虾(Fenneropenaeus chinensis)耐盐碱和WSSV感染响应的ABC转运蛋白基因组范围内的鉴定及功能分析
Zhaoxia Li,Chuanshi Jia,Yalun Li et al.
Zhaoxia Li et al.
ATP-binding cassette (ABC) transporters play crucial roles in stress responses across organisms, yet their functions in Fenneropenaeus chinensis remain largely unknown. In this study, we identified 42 FcABC genes (FcABCs) in the F. chinensi...
IRAK1BP1 negatively regulated innate immune response via NF-κB signal pathway in blunt snout bream (Megalobrama amblycephala) [0.03%]
IRAK1BP1通过NF-κB信号通路负向调控团头鲂固有免疫应答
Yuandong Sun,Chunfang Li,Hongyang Sun et al.
Yuandong Sun et al.
Interleukin receptor-associated kinase (IRAK)-1 binding protein 1 (IRAK1BP1) is a vital factor in preventing dangerous overproduction of proinflammatory cytokines by the innate immune system. The structure and function of IRAK1BP1 have been...
CcFTR54 suppresses SVCV replication by promoting NBR1-mediated autophagic degradation of P protein [0.03%]
CcFTR54通过促进NBR1介导的P蛋白自噬降解抑制SVCV复制
Hongxia Gao,Fei Wang,Yihan Wang et al.
Hongxia Gao et al.
The tripartite motif-containing (TRIM) protein family is crucial for antiviral innate immunity. In teleost, finTRIM proteins (FTRs) represent a fish-specific TRIM subfamily that underwent extensive lineage-specific expansion. Nevertheless, ...