CXCL10, a conserved bactericidal chemokine, harbors an antibacterial α-helix and mediates pro-inflammatory and chemotactic activities via p-ERK and p-AKT signaling in large yellow croaker (Larimichthys crocea) [0.03%]
大黄鱼(Clarkei大黄鱼)CXCL10通过p-ERK和p-AKT信号介导促炎和趋化活性并具有抗菌α-螺旋结构的保守杀菌细胞因子
Yanqi Zhang,Yangxi Xiang,Lianlian Sun et al.
Yanqi Zhang et al.
CXCL10 is a multifunctional chemokine known for its roles in inflammation, chemotaxis, and immune regulation across vertebrates. However, whether CXCL10 exerts evolutionarily conserved functions in teleosts and the structural basis underlyi...
Molecular characterization and expression analysis of three complement genes: C4B, C6 and C7 in Mastacembelus armatus under Aeromonas veronii infection [0.03%]
感染Aeromonas veronii下Mastacembelus armatus的补体系统C4B、C6和C7基因分子特征及表达分析
Kaifeng Wang,Ziyan Deng,Shengyue Lin et al.
Kaifeng Wang et al.
To investigate the immune functions and evolutionary features of complement genes in Mastacembelus armatus, three complement genes (MaC4B, MaC6 and MaC7) were cloned and characterized for the first time, and their expression profiles upon A...
Corrigendum to "Fish Meteorin-like factor promotes migration, proliferation and phagocytic activity of monocytes/macrophages" [Fish Shellfish Immunol.171 (2026) 111193] [0.03%]
关于“鱼Meteorin样因子促进单核细胞/巨噬细胞迁移、增殖和吞噬活性”的勘误[鱼类与海鲜免疫学171(2026)111193]
Yueshuang Ji,Yinghao Huang,Shengbin Lu et al.
Yueshuang Ji et al.
Published Erratum
Fish & shellfish immunology. 2026 Jun 19:111519. DOI:10.1016/j.fsi.2026.111519 2026
The TLR9/NF-κB and cGAS/STING pathways mediate the assembly of the NLRP3 inflammasome induced by Singapore Grouper Iridovirus DNA [0.03%]
TLR9/NF-κB和cGAS/STING途径介导新加坡 grouper 噬病毒DNA诱导的NLRP3炎性小体组装
Lifang Cao,Lu Yang,Runjian Huang et al.
Lifang Cao et al.
Groupers are economically significant fish in southern China and Southeast Asia, where viral diseases severely hinder the sustainable development of aquaculture. Singapore grouper iridovirus (SGIV) is a highly pathogenic virus in groupers t...
The inducible nitric oxide synthase (iNOS) of Eriocheir sinensis exerts antibacterial effects through apoptosis [0.03%]
中华绒螯蟹诱导型一氧化氮合酶(iNOS)通过诱导细菌凋亡发挥抗菌作用
Linjie Li,Wenxing Huang,Yingying Han et al.
Linjie Li et al.
Inducible nitric oxide synthase (iNOS) is a key molecule in the invertebrate innate immune system. However, its precise mechanism of action remains poorly understood. In this study, iNOS expression was significantly induced following challe...
The Outer Capsid Spike Protein Vp55 of Grass Carp Reovirus Interacts with Host Toll-like Receptor 2 to Modulate the Nf-κb-Tnfα Antiviral Signaling Pathway [0.03%]
草 carp 呼肠孤病毒外衣壳刺突蛋白 Vp55通过与 Toll 样受体 2互作调控 NF-κB-TNFα 抗病毒信号通路
Jiarong Xie,Ning Xu,Weijun Wu et al.
Jiarong Xie et al.
Grass carp reovirus (GCRV) causes hemorrhagic disease and poses a serious threat to the grass carp aquaculture industry in China. The outer capsid spike protein Vp55 of the GCRV-104 strain, similar to its counterparts in other orthoreovirus...
A macin family antimicrobial peptide from Atrina pectinata exhibiting dual functions in direct bactericidal activity and hemocyte immune modulation [0.03%]
一种直接杀菌和参与血细胞免疫调节的文蛤抗菌肽
Yan-Ru Chen,Kun-Yu Zhao,Shun-Xin Hu et al.
Yan-Ru Chen et al.
Antimicrobial peptides (AMPs) are key effectors of innate immunity in invertebrates. In this study, a novel macin family AMP (designated ApMacin) was identified and functionally characterized from the economically important bivalve Atrina p...
The membrane receptor Basigin facilitates WSSV infection by binding envelope proteins and suppressing antiviral gene expression in shrimp [0.03%]
基底胶蛋白通过结合包膜蛋白并抑制基因表达促进对虾感染白斑综合征病毒
Wanli Lu,Tongxin Lin,Mengting Luo et al.
Wanli Lu et al.
Basigin, a pattern recognition receptor (PRR), identified from Penaeus vannamei, mediates the NF-κB/Dorsal signaling pathway. Although previous studies have demonstrated its involvement in the antibacterial immune response of shrimp, the s...
HMGB1 down-regulation drives efferocytosis and inflammation suppression: A novel immune adaptation mechanism in Schizopygopsis younghusbandi responding to heat stress [0.03%]
HMGB1下调驱动摄取坏死细胞和抑制炎症：热应激下异胸高等裂腹鱼的一种新的免疫适应机制
Zongfu Chen,Jinlin Wang,Yunpeng Jiang et al.
Zongfu Chen et al.
Schizopygopsis younghusbandi is a fish species endemic to the Yarlung Tsangpo River system on the Qinghai-Tibet Plateau and possesses unique adaptive capabilities to extreme environments; however, its thermoadaptive mechanism remains unclea...
A CXCL20a point mutant enhances the immune protection induced by an inactivated GCRV vaccine in grass carp [0.03%]
草鱼脑肝炎病毒灭活疫苗中增加CXCL20a点突变体可增强免疫保护力
Yizhong Lu,Shijie Wang,Guanyu Chen et al.
Yizhong Lu et al.
Inactivated vaccines are widely used in fish disease control, but their limited immunogenicity restricts their protective efficacy. In this study, grass carp CXCL20a was optimized by site-directed mutagenesis, and an S35R mutant (M-C20) was...