A novel bridged Dicarboximide derivative: A highly effective antifungal agent for managing plant pathogens [0.03%]
一种新型桥联二羧酰亚胺衍生物：一种高效抗真菌剂，用于管理植物病原体
Zili Ren,Pengjie Yang,Hongzhong Chen et al.
Zili Ren et al.
Increasing resistance to dicarboximide fungicides (DCFs) and their associated environmental risks necessitate the development of novel and eco-friendly antifungal agents. In this study, a series of novel DCF derivatives (C1-C34) were design...
Marzieh Alikarami,Kaveh Rahimi Mamaghani,Bruno Leonardo Mendes et al.
Marzieh Alikarami et al.
Fusarium diseases pose a global challenge to crop productivity, grain quality, and food security, driven by resilient soilborne infections and persistent mycotoxin contamination. Reliance on conventional fungicides has become increasingly u...
A novel endophytic fungus Fusarium oxysporum G-07 exhibits antagonism against Rhizoctonia solani and promotes growth in Scutellaria baicalensis [0.03%]
一株新型内生菌Fusarium oxysporum G-07具有拮抗立枯丝核菌和促进黄芩生长的作用
Xiao-Qing Wang,Jiao Jiao,Qing-Yan Gai et al.
Xiao-Qing Wang et al.
In China, the continuous cropping leads to frequent outbreaks of root rot caused by the pathogen Rhizoctonia solani and soil fertility degradation, which are the primary causes of reduced yield and quality of the famous medicinal/edible pla...
Thiamethoxam resistance evolution, fitness cost, and transcriptome-based functional insights in the whitefly Bemisia tabaci [0.03%]
新烟碱类杀虫剂噻虫嗪的抗性演化、负向表型作用及其功能基因组学研究（以烟粉虱为材料）
Jing Yang,Qimei Tan,Xuegao Wei et al.
Jing Yang et al.
The evolution of insecticide resistance in Bemisia tabaci poses a serious threat to the sustainable control of this globally important pest. In this study, a thiamethoxam-resistant strain (TMX-G15) was established through 15 consecutive gen...
Design and synthesis of mesoionic compounds containing benzoxacycle for the control of piercing-sucking pests [0.03%]
含有苯氧杂环的介离子化合物的设计合成及其对刺吸式害虫的防控效果研究
Yuqin Luo,Ronghua Wang,Luoman Zhang et al.
Yuqin Luo et al.
Piercing-sucking pests cause significant agricultural losses, and widespread neonicotinoid use has led to resistance and ecological concerns. Mesoionic compounds show broad-spectrum insecticidal activity with low cross-resistance, yet the m...
Rational design and synthesis of a safe sNPF-mimetic peptide with cross-species insecticidal activity [0.03%]
一种具有跨物种杀虫活性的安全sNPF拟态多肽的理性设计与合成
Yuanlin Zhou,Chunyue Wang,Xiang Yao et al.
Yuanlin Zhou et al.
Short neuropeptide F (sNPF) is an insect-specific neuropeptide composed of 6-19 amino acids and features a conserved RLRFa motif, playing a pivotal role in regulating insect growth, development, feeding behavior, and energy homeostasis. Dis...
RNA interference-based pesticides: Mechanism, application, and commercialization in sustainable pest management [0.03%]
基于RNA干扰的农药：作用机制、应用及可持续害虫管理中的商业化
Ziyang Li,Yuming Liu,Yinqi Liang et al.
Ziyang Li et al.
Conventional chemical pesticides remain critical for protecting crops from arthropod pests, but their overuse drives ecological harm, including environmental contamination, ecosystem disruption, food residue persistence, and widespread pest...
Functional and structural characterization of OBP7 reveals a sequestration-based chlorpyrifos resistance mechanism in Nilaparvata lugens [0.03%]
OBP7的功能和结构表征揭示了二化螟中氯 pyrifos 抵抗的捕获机制
Ling Lin,Mengqing Deng,Libin Lin et al.
Ling Lin et al.
The evolution of insecticide resistance threatens sustainable pest control, urging the discovery of mechanisms beyond classical metabolic detoxification and target-site mutations. In this study, we report a sequestration-based resistance me...
Sodium pentachlorophenol induces inflammatory damage via the ATP2B4/Ca2+/ROS signaling axis in mouse testes [0.03%]
五氯酚钠通过ATP2B4/Ca2+/ROS信号轴诱导小鼠睾丸炎性损伤
Yuxi Zhang,Ruoning Wu,Lidong Chao et al.
Yuxi Zhang et al.
Sodium pentachlorophenol (PCP-Na) is widely used in agricultural production and daily life as an insecticide, herbicide, and molluscicide, and it is stable and difficult to biodegrade in soil after application. The mechanism by which it cau...
Discovery of a novel compound against BmNPV using virtual screening based on the protein structure of the viral whole genome [0.03%]
基于病毒整个基因组蛋白质结构的虚拟筛选发现针对BmNPV的新化合物
Lin Zhang,Ying Ma,Junchi Hu et al.
Lin Zhang et al.
Currently, effective antiviral drugs against Bombyx mori nucleopolyhedrovirus (BmNPV) are still lacking, which has caused significant economic damage to the sericulture industry. Virtual screening and artificial intelligence provide opportu...